INT80161

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 9.66
Pain Relevance 7.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
visceral 2
brain 2
plasma 1
pituitary 1
bowel 1
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
central sensitization 8 99.84 Very High Very High Very High
antagonist 27 99.60 Very High Very High Very High
withdrawal 30 99.56 Very High Very High Very High
Enkephalin 3 99.28 Very High Very High Very High
Morphine 9 99.12 Very High Very High Very High
amygdala 185 99.06 Very High Very High Very High
Visceral pain 6 98.80 Very High Very High Very High
Pain 105 98.36 Very High Very High Very High
noradrenaline 5 97.68 Very High Very High Very High
depression 79 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 58 99.76 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 99.56 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 98.80 Very High Very High Very High
Suicidal Behaviour 123 98.38 Very High Very High Very High
Pain 101 98.36 Very High Very High Very High
Eclampsia 8 98.24 Very High Very High Very High
Anxiety Disorder 6 98.04 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 97.68 Very High Very High Very High
Depression 102 97.56 Very High Very High Very High
Functional Bowel Disorder 5 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, CRF1R activation may not contribute to the functional interaction between NA and CRF systems in mediating morphine withdrawal-activation of brain stress neurocircuitry.
Positive_regulation (activation) of CRF1R in brain associated with stress, noradrenaline, withdrawal and morphine
1) Confidence 0.67 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20159948 Disease Relevance 0.32 Pain Relevance 1.41
Here, this dual action of CRF was differentiated by selective (in)activation of the CRF1 and CRF2 receptor prior to a visceral pain stimulus.
Positive_regulation (activation) of CRF1 in visceral associated with visceral pain
2) Confidence 0.66 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15916630 Disease Relevance 0.24 Pain Relevance 0.47
Facilitation by CRF (0.1 microM) was reversed by a selective CRF1 receptor antagonist (NBI27914, 10 microM) but not a CRF2 receptor antagonist (astressin-2B, 100 microM) and by a protein kinase A (PKA) inhibitor (KT5720, 100 microM) but not a protein kinase C inhibitor (GF109203X, 100 microM).
Neg (not) Positive_regulation (selective) of CRF1 associated with antagonist and kinase c inhibitor
3) Confidence 0.47 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18171711 Disease Relevance 0.50 Pain Relevance 0.69
Mechanisms of pain-related PKA activation in the CeLC are not entirely clear but our previous studies suggest that CGRP1 [22] and CRF1 [30] receptors could be upstream of PKA activation.
Positive_regulation (activation) of CRF associated with pain and amygdala
4) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 1.16 Pain Relevance 1.50
CONCLUSION: These results suggested an up-regulation of thalamus CRF-R1 is associated with visceral hyperalgesia in the rat model of NMS.


Positive_regulation (regulation) of CRF-R1 in visceral
5) Confidence 0.45 Published 2010 Journal Neuro Endocrinol. Lett. Section Body Doc Link 20424584 Disease Relevance 0.12 Pain Relevance 0
These findings lend support to the hypothesis that hyperactivation of CRF1 receptors may contribute to the co-morbidity of anxiety and depression and irritable bowel syndrome.
Positive_regulation (hyperactivation) of CRF1 in bowel associated with depression, spastic colon and anxiety disorder
6) Confidence 0.43 Published 2002 Journal Eur J Surg Suppl Section Abstract Doc Link 16144197 Disease Relevance 1.26 Pain Relevance 0.72
In contrast, distal CRFR1 and CRFR2 levels were higher in MS rats but were significantly reduced post OF stress.
Positive_regulation (higher) of CRFR1 associated with stress
7) Confidence 0.31 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07
Immunofluorescent dual-labeling demonstrated increased activation of both CRFR1 (MS: 79.6+/-4.4% vs.
Positive_regulation (activation) of CRFR1
8) Confidence 0.29 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.28 Pain Relevance 0.07
Urocortin (Ucn) is related to corticotropin-releasing hormone (CRH), and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors (CRHR).
Positive_regulation (stimulate) of CRHR in brain associated with stress
9) Confidence 0.22 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027877 Disease Relevance 0.32 Pain Relevance 0.03
In addition, LPS increased corticosterone release, increased plasma intereleukin (IL)-1beta release, increased IL-1beta and IL-6 mRNA in hippocampus, increased corticotropin releasing hormone (CRH) mRNA in pituitary, and decreased CRH-1 mRNA in pituitary.
Positive_regulation (decreased) of CRH-1 mRNA in plasma
10) Confidence 0.20 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15565429 Disease Relevance 0.06 Pain Relevance 0
Mechanisms of pain-related PKA activation in the CeLC remained to be determined, but both CGRP1 and CRF1 receptors couple to PKA activation.
Positive_regulation (activation) of CRF associated with pain and amygdala
11) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 1.08 Pain Relevance 1.81
However, levels of placental cell-free corticotrophin releasing hormone mRNA were significantly increased in labour in both normal pregnancy and pre-eclampsia and were still high 24 h after delivery in the pre-eclamptic women.
Positive_regulation (increased) of corticotrophin releasing hormone mRNA associated with eclampsia
12) Confidence 0.05 Published 2008 Journal Placenta Section Abstract Doc Link 18834630 Disease Relevance 0.58 Pain Relevance 0.09
For example, in suicide victims, hypothalamus-pituitary-adrenal axis hyperactivity has been linked with elevated corticotrophin-releasing hormone levels in the cerebrospinal fluid, reduced corticotrophin-releasing hormone binding sites in the frontal cortex, augmented pro-opiate-melanocortic RNA density in the pituitary, large corticotrophic cell size, and alterations in the mineralocorticoid to glucocorticoid receptor messenger RNA (mRNA) ratio in the hippocampus of suicide victims.71–76 Also, a consistent association has been found between subsequently completed suicide and nonsuppression of cortisol in the dexamethasone suppression test.77–82
Positive_regulation (elevated) of corticotrophin-releasing hormone in pituitary associated with suicidal behaviour, urological neuroanatomy, hippocampus, opiate, attention deficit hyperactivity disorder and dexamethasone
13) Confidence 0.04 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.75 Pain Relevance 0.35
Dual labelling showed that very few FG-labelled cells also stained for corticotrophin-releasing hormone, none for AVP or enkephalin.
Positive_regulation (stained) of corticotrophin-releasing hormone associated with enkephalin
14) Confidence 0.03 Published 2006 Journal Neuroendocrinology Section Abstract Doc Link 17047317 Disease Relevance 0.56 Pain Relevance 0.10

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