INT80162

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Context Info
Confidence 0.80
First Reported 1999
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 0.60
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ucn)
Anatomy Link Frequency
neuronal 2
brain 2
colon 1
pituitary 1
enteric nervous system 1
Ucn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 57 99.76 Very High Very High Very High
tetrodotoxin 15 98.44 Very High Very High Very High
Central nervous system 5 93.68 High High
Calcitonin gene-related peptide 19 60.16 Quite High
substance P 18 27.68 Quite Low
Neuropeptide 7 25.00 Low Low
Peripheral nervous system 3 25.00 Low Low
local anesthetic 2 25.00 Low Low
lidocaine 2 25.00 Low Low
psoriasis 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 54 99.20 Very High Very High Very High
Edema 2 66.72 Quite High
Increased Venous Pressure Under Development 3 54.88 Quite High
Targeted Disruption 22 11.08 Low Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urocortin (Ucn) is related to corticotropin-releasing hormone (CRH), and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors (CRHR).
Localization (released) of Ucn in brain associated with stress
1) Confidence 0.80 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027877 Disease Relevance 0.30 Pain Relevance 0.03
We investigated the effect of CRF and UcnI on colonic motor function and examined the localization of CRF, UcnI, CRF receptors, choline acetyltransferase (ChAT), and 5-HT.
Spec (examined) Localization (localization) of UcnI
2) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.22
Furthermore, the localization of UcnI in the enteric nervous system (ENS) of the colon is unknown.
Localization (localization) of UcnI in enteric nervous system
3) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.19
Urocortin (Ucn) is related to corticotropin-releasing hormone (CRH), and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors (CRHR).
Localization (released) of Urocortin in brain associated with stress
4) Confidence 0.74 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027877 Disease Relevance 0.30 Pain Relevance 0.03
UcnI and ChAT, as well as UcnI and 5-HT, were colocalized in some of the neuronal cells of the myenteric plexus.
Localization (colocalized) of UcnI in neuronal
5) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.37
UcnI and ChAT, as well as UcnI and 5-HT, were colocalized in some of the neuronal cells of the myenteric plexus.
Localization (colocalized) of UcnI in neuronal
6) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.38
The localizations of CRF, UcnI, CRF receptors, ChAT, and 5-HT in the colon were investigated by immunohistochemistry.
Spec (investigated) Localization (localizations) of UcnI in colon
7) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.41
An autocrine or paracrine action of urocortin is feasible because urocortin was localised in corticotrophs in fetal sheep pituitary and transfection of sheep pituitary cells in culture with urocortin antisense oligonucleotides depressed ACTH secretion, whereas exogenous urocortin stimulated ACTH release (586).
Localization (localised) of urocortin in pituitary
8) Confidence 0.10 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.04

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