INT80175

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 14.69
Pain Relevance 3.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
NHEK 6
joints 4
pancreas 4
fibroblasts 2
pyramidal neurons 2
HRAS (Homo sapiens)
HRAS - G12V (1)
Pain Link Frequency Relevance Heat
Nicotine 68 99.84 Very High Very High Very High
Osteoarthritis 264 99.76 Very High Very High Very High
Chronic pancreatitis 16 99.60 Very High Very High Very High
Pain 151 99.04 Very High Very High Very High
Pyramidal cell 1 98.80 Very High Very High Very High
Inflammation 68 98.68 Very High Very High Very High
fibrosis 9 95.92 Very High Very High Very High
Cholecystokinin 32 95.00 High High
metalloproteinase 23 80.24 Quite High
cINOD 44 78.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 67 100.00 Very High Very High Very High
Pancreatic Cancer 28 100.00 Very High Very High Very High
Disease 165 99.96 Very High Very High Very High
Hyperplasia 40 99.90 Very High Very High Very High
Osteoarthritis 252 99.76 Very High Very High Very High
Pancreatitis 42 99.60 Very High Very High Very High
Pancreatic Ductal Carcinoma 34 99.52 Very High Very High Very High
Pain 146 99.04 Very High Very High Very High
INFLAMMATION 82 98.68 Very High Very High Very High
Adenocarcinoma 16 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At an early stage of AD, elevated expression of p21ras co-localizes with p16Ink4 in pyramidal neurons [213].
Positive_regulation (elevated) of Gene_expression (expression) of p21ras in pyramidal neurons associated with pyramidal cell and disease
1) Confidence 0.67 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.90 Pain Relevance 0.05
Studies of cancers of the pancreas and breast have shown that OCs may interact with genetic alterations in tumors such as K-ras mutations or p53 overexpression (Hoyer et al. 2002; Porta et al. 1999; Slebos et al. 2000).
Positive_regulation (overexpression) of Gene_expression (overexpression) of K-ras in pancreas associated with cancer
2) Confidence 0.67 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.76 Pain Relevance 0
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Positive_regulation (evaluation) of Gene_expression (expression) of K-ras in pancreas associated with hyperplasia
3) Confidence 0.49 Published 1999 Journal Hum. Pathol. Section Title Doc Link 10029438 Disease Relevance 0.77 Pain Relevance 0.07
We report that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acinar/centroacinar cells or their precursors into ductal-like cells.
Positive_regulation (results) of Gene_expression (expression) of K-Ras (G12V) in embryonic cells associated with adenocarcinoma
4) Confidence 0.49 Published 2007 Journal Cancer Cell Section Abstract Doc Link 17349585 Disease Relevance 0.85 Pain Relevance 0.15
Many studies have investigated tumor-mediated molecular alterations of the pancreatic juice, as k-ras mutations, telomerase reactivation, or promoter methylation of the tumor-suppressor genes p16INK4a and p14ARF.
Spec (investigated) Positive_regulation (reactivation) of Gene_expression (mutations) of k-ras associated with cancer
5) Confidence 0.49 Published 2004 Journal Dig Dis Section Abstract Doc Link 15753605 Disease Relevance 0.79 Pain Relevance 0.09
K-ras point mutation, telomerase activity, and p53 overexpression were analyzed using mutant allele specific amplification, the telomeric repeat amplification protocol, and immunohistochemical staining, respectively.
Positive_regulation (overexpression) of Gene_expression (overexpression) of K-ras
6) Confidence 0.49 Published 2003 Journal Oncol. Rep. Section Abstract Doc Link 12579258 Disease Relevance 0.96 Pain Relevance 0.10
K-ras-transfected cells formed tumors more quickly when injected into severe combined immunodeficiency disease mice than parental cells, and this tumorigenesis was suppressed by treatment with sulindac.
Positive_regulation (transfected) of Gene_expression (transfected) of K-ras associated with cancer and severe combined immunodeficiency
7) Confidence 0.49 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11118042 Disease Relevance 0.53 Pain Relevance 0.08
Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: comparison with K-ras mutation.
Positive_regulation (mutations) of Gene_expression (Detection) of K-ras associated with cancer and pancreatic cancer
8) Confidence 0.49 Published 1999 Journal Clin. Cancer Res. Section Title Doc Link 10353750 Disease Relevance 0.74 Pain Relevance 0.07
A 24-h treatment with DFMO caused a dose-dependent decrease in the colony-forming ability of cells expressing an activated K-ras but had no effect on the viability of the parental Caco-2 cells.
Positive_regulation (activated) of Gene_expression (expressing) of K-ras in Caco-2
9) Confidence 0.49 Published 2000 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 11097222 Disease Relevance 0.65 Pain Relevance 0.05
Mutant oncogene, H-ras, was overexpressed in nicotine-treated pancreatic tissue.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of H-ras associated with nicotine
10) Confidence 0.45 Published 2003 Journal Tob Induc Dis Section Abstract Doc Link PMC2669561 Disease Relevance 0.69 Pain Relevance 0.38
Mutant oncogene, H-ras, was overexpressed in nicotine-treated pancreatic tissue.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of H-ras associated with nicotine
11) Confidence 0.45 Published 2003 Journal Tob Induc Dis Section Abstract Doc Link PMC2671550 Disease Relevance 0.69 Pain Relevance 0.38
In conclusion, our results derived from registry data on 8,043 hips indicate that HA coating does not enhance the survival of cups when using revision for aseptic cup loosening as an endpoint.
Neg (not) Positive_regulation (enhance) of Gene_expression (coating) of HA in hips
12) Confidence 0.33 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2856204 Disease Relevance 0.17 Pain Relevance 0
The production of HA in NHEK was increased after incubation with the fermentation product of CCRC 14061, acid hydrolysate, PR decoction and retinoic acid (22+/- 0.2%), whereas no increase of HA concentration was found after incubation with the fermentation product of CCRC 11846.
Positive_regulation (increased) of Gene_expression (production) of HA in NHEK
13) Confidence 0.14 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20128051 Disease Relevance 0.19 Pain Relevance 0.07
In conclusion, PR preparations would stimulate HA production in NHEK cells which might be used as a new cosmetic ingredient in moisturizers and an anti-aging agent.
Positive_regulation (stimulate) of Gene_expression (production) of HA in NHEK associated with aging
14) Confidence 0.12 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20128051 Disease Relevance 0.10 Pain Relevance 0
Furthermore, the PR hydrolysate stimulated the HA production of NHEK, and the effect was dose-dependent (18.6%-83.9%).
Positive_regulation (stimulated) of Gene_expression (production) of HA in NHEK
15) Confidence 0.09 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20128051 Disease Relevance 0.11 Pain Relevance 0.05
Specifically, we investigated if HA production can be stimulated by adding GlcN and if GlcN affects gene expression of the HAS enzymes.


Positive_regulation (stimulated) of Gene_expression (production) of HA
16) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.48 Pain Relevance 0.37
Since GlcN is an important building block of HA and HA is found in high amounts in articular joints, increasing HA production through the administration of GlcN might be a way to explain the pain relieving effect of GlcN.
Positive_regulation (increasing) of Gene_expression (production) of HA in joints associated with pain
17) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.95 Pain Relevance 0.78
The synthesis of HA requires GlcN as one of its main building blocks.
Positive_regulation (requires) of Gene_expression (synthesis) of HA
18) Confidence 0.03 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2553787 Disease Relevance 0.55 Pain Relevance 0.29
The increased amount of HA in the culture medium might be explained by the fact that addition of GlcN-HCl simply led to more building blocks that are required for the synthesis of HA.
Positive_regulation (required) of Gene_expression (synthesis) of HA
19) Confidence 0.03 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0 Pain Relevance 0
Namely, the IC adjacent to the atypical MGH (PanIN-1B), which is sometimes proliferative cell, had the mucin phenotypic expression and high frequency of K-ras mutation as well as PDC.
Positive_regulation (frequency) of Gene_expression (expression) of K-ras mutation associated with pancreatic ductal carcinoma and hyperplasia
20) Confidence 0.03 Published 2005 Journal J Carcinog Section Body Doc Link PMC1185555 Disease Relevance 1.66 Pain Relevance 0

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