INT80193

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Context Info
Confidence 0.23
First Reported 1999
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 10.95
Pain Relevance 15.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
IB4 14
neurons 9
DRG 2
sensory neurons 1
glial cell 1
RT1-M4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 47 100.00 Very High Very High Very High
calcitonin gene related peptide 8 99.88 Very High Very High Very High
Nerve growth factor 45 99.70 Very High Very High Very High
nociceptor 47 99.34 Very High Very High Very High
substance P 16 99.28 Very High Very High Very High
nav1.8 15 99.08 Very High Very High Very High
dorsal root ganglion 44 98.98 Very High Very High Very High
Spinal cord 28 98.60 Very High Very High Very High
Nav1.9 19 98.48 Very High Very High Very High
chemokine 204 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 99.54 Very High Very High Very High
Ganglion Cysts 52 98.98 Very High Very High Very High
Nervous System Injury 69 97.36 Very High Very High Very High
Nociception 77 96.22 Very High Very High Very High
Hypoalagesia 2 95.16 Very High Very High Very High
Peripheral Neuropathy 5 92.16 High High
Cv Unclassified Under Development 2 91.40 High High
Injury 33 90.96 High High
INFLAMMATION 14 90.84 High High
Shock 6 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mammalian nociceptors have been classified into subclasses based on differential neurotrophin sensitivity and binding of the plant isolectin B4 (IB4).
IB4 Binding (binding) of in nociceptors associated with nociceptor
1) Confidence 0.23 Published 2007 Journal Neuroscience Section Abstract Doc Link 17101230 Disease Relevance 0.07 Pain Relevance 0.53
As the central boutons of type Ia represent varicosities from the fibers which bind IB4, the ultrastructural changes confirmed that there was a bona fide transient loss of varicosities, not simply a loss of IB4 binding.
IB4 Binding (binding) of in IB4 associated with increased venous pressure under development
2) Confidence 0.20 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.79 Pain Relevance 0.58
As the central boutons of type Ia represent varicosities from the fibers which bind IB4, the ultrastructural changes confirmed that there was a bona fide transient loss of varicosities, not simply a loss of IB4 binding.
IB4 Binding (bind) of in IB4 associated with increased venous pressure under development
3) Confidence 0.20 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.80 Pain Relevance 0.57
The isolectin I-B4 (IB4) binds specifically to a subset of small sensory neurons.
IB4 Binding (binds) of in sensory neurons
4) Confidence 0.06 Published 2001 Journal Neuroscience Section Abstract Doc Link 11738138 Disease Relevance 0.14 Pain Relevance 0.07
CGRP afferents terminated mostly in LI and the outer two-thirds of lamina II, whereas the termination area of fibers binding IB4 was centered on the middle one-third of lamina II at all ages studied.
IB4 Binding (binding) of in IB4 associated with calcitonin gene-related peptide
5) Confidence 0.06 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18383051 Disease Relevance 0.23 Pain Relevance 0.51
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons.
IB4 Binding (Binding) of in neurons associated with ganglion cysts, nociception and dorsal root ganglion
6) Confidence 0.05 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16822986 Disease Relevance 0.41 Pain Relevance 0.50
Cytotoxic targeting of isolectin IB4-binding sensory neurons.
IB4 Binding (binding) of in IB4 associated with nociceptor
7) Confidence 0.04 Published 2001 Journal Neuroscience Section Title Doc Link 11738138 Disease Relevance 0.41 Pain Relevance 0.24
All types were examined for the presence of substance P (SP), calcitonin gene related peptide (CGRP) and binding of isolectin B4 (IB4).
IB4 Binding (binding) of in IB4 associated with calcitonin gene related peptide and substance p
8) Confidence 0.04 Published 2002 Journal Neuroscience Section Abstract Doc Link 12401318 Disease Relevance 0.07 Pain Relevance 0.76
Types 5 and 8 co-expressed SP and CGRP immunoreactivity and also bound IB4.
IB4 Binding (bound) of in IB4 associated with calcitonin gene related peptide and substance p
9) Confidence 0.04 Published 2002 Journal Neuroscience Section Abstract Doc Link 12401318 Disease Relevance 0.07 Pain Relevance 0.73
In contrast, an equal number of Na(v)1.9 cells bind IB4 and TrkA in embryonic life.
IB4 Binding (bind) of in IB4
10) Confidence 0.04 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.65
Immunointensities of IB4 binding in C-neurons were positively correlated with those of Nav1.9 but not Nav1.8.
IB4 Binding (binding) of in neurons associated with nav1.8 and nav1.9
11) Confidence 0.03 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16822986 Disease Relevance 0.22 Pain Relevance 1.63
The other binds IB4 and expresses the glial cell line-derived neurotrophic factor receptor.
IB4 Binding (binds) of in glial cell
12) Confidence 0.03 Published 2004 Journal Spine Section Body Doc Link 15131432 Disease Relevance 0.17 Pain Relevance 0
The percentage of CGRP-ir neurons was significantly higher than that of IB4-binding neurons in both groups (P < 0.001, each).
IB4 Binding (binding) of in neurons
13) Confidence 0.03 Published 2004 Journal Spine Section Body Doc Link 15131432 Disease Relevance 0.11 Pain Relevance 0
At E17, almost all Na(v)1.8-expressing neurons also express the high-affinity NGF receptor TrkA, and only a small proportion bind to IB4, a marker for c-ret-expressing (glial-derived neurotrophic factor-responsive) neurons.
IB4 Binding (bind) of in neurons
14) Confidence 0.03 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.75
Because IB4 binding neurons differentiate from TrkA neurons in the postnatal period, the proportion of Na(v)1.8 cells that bind to IB4 increases, in parallel with a decrease in the proportion of Na(v)1.8-TrkA co-expressing cells.
IB4 Binding (bind) of in neurons
15) Confidence 0.02 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.70
Relatively few (<6%) CCR2-positive neurons were colocalized with IB4-binding neurons ipsilateral (Fig. 2F and Fig. 3) or contralateral to the nerve injury at POD 14 (Fig. 3).
IB4 Binding (binding) of in neurons associated with nervous system injury
16) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.32 Pain Relevance 0.45
However, a two-fold increase in the number of neurons positive for both IP-10-immunoreactivity and IB4-binding (19.08 ± 2.31%; n = 6) was evident at POD14 (p < 0.01) (Fig. 3, Fig. 8F, I).


IB4 Binding (binding) of in IB4
17) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.32 Pain Relevance 0.37
DRG neurons innervating the colon were identified by 1,1'-dioleoyl-3,3,3',3-tetramethylindocarbocyanine methanesulfonate (DiI) fluorescence labeling and were immunostained for isolectin B4 (IB4) binding to classify these colonic neurons.
IB4 Binding (binding) of in neurons
18) Confidence 0.01 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19491827 Disease Relevance 0.16 Pain Relevance 0
Small nociceptive DRG neurons are classified into nerve growth factor (NGF)-dependent neurons and glial cell line-derived neurotrophic factor (GDNF)-dependent neurons and they can be distinguished by their reactivity for CGRP and IB4, respectively.
IB4 Binding (reactivity) of in DRG associated with nociception, dorsal root ganglion, nerve growth factor and calcitonin gene-related peptide
19) Confidence 0.01 Published 2004 Journal Life Sci. Section Abstract Doc Link 15041445 Disease Relevance 1.02 Pain Relevance 0.92
A proportion of the CB1 receptor-like immunopositive neurones was immunostained for CGRP (31.7+/-5%) and IB4 (48.2%+/-7.5), with a minimal (1%) co-expression of CGRP and IB4 binding.
IB4 Binding (binding) of in IB4 associated with calcitonin gene-related peptide
20) Confidence 0.01 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934481 Disease Relevance 0.36 Pain Relevance 0.48

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