INT8021

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 43
Total Number 46
Disease Relevance 31.46
Pain Relevance 10.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
chondrocytes 3
plasma cell 3
cartilage 3
articular cartilage 2
ears 2
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Patient controlled alalgesia 84 100.00 Very High Very High Very High
cytokine 140 99.68 Very High Very High Very High
Pain score 24 99.68 Very High Very High Very High
Perioperative pain 68 99.60 Very High Very High Very High
antagonist 3 99.56 Very High Very High Very High
Inflammation 221 99.50 Very High Very High Very High
adenocard 69 99.32 Very High Very High Very High
Pain 166 99.12 Very High Very High Very High
Morphine 60 98.24 Very High Very High Very High
Osteoarthritis 347 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaphylaxis 215 100.00 Very High Very High Very High
Hypersensitivity 203 100.00 Very High Very High Very High
Calcification 1059 99.88 Very High Very High Very High
Post Operative Pain 72 99.60 Very High Very High Very High
Pain 224 99.54 Very High Very High Very High
INFLAMMATION 238 99.50 Very High Very High Very High
Congenital Anomalies 85 99.40 Very High Very High Very High
Edema 85 99.16 Very High Very High Very High
Aging 324 98.48 Very High Very High Very High
Syndrome 30 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cells such as osteoblasts and chondrocytes that normally express NPP1 relatively robustly, NPP1 and NPP3 increase intracellular PPi, suspected to be in large part in the lumen of the ER and Golgi [12, 16, 31].
Gene_expression (express) of NPP1 in lumen
1) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.27 Pain Relevance 0.05
induces both NPP1 expression and elevation of extracellular PPi [12, 31, 43].
Gene_expression (expression) of NPP1
2) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.62 Pain Relevance 0.13
It is not yet known if NPP1 expression is depressed or absent in ttw/ttw mice, or if the ttw mutation, like many of the NPP1 mutations seen in humans with GACI, critically impairs catalytic activity, putatively by interfering with substrate binding.
Neg (absent) Gene_expression (expression) of NPP1
3) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.72 Pain Relevance 0.05
It will be of interest to see if the implicated NPP1 sequence variants affect NPP1 expression and function.
Gene_expression (expression) of NPP1
4) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.96 Pain Relevance 0.26
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Gene_expression (expression) of PC-1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
5) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.65 Pain Relevance 0.28
This support mechanism becomes dysregulated in aging cartilage, where extracellular PPi excess, mediated in part by upregulated NPP1 expression stimulates calcification.
Gene_expression (expression) of NPP1 in cartilage associated with calcification and aging
6) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2254483 Disease Relevance 0.29 Pain Relevance 0
Physiologic chondrocyte PPi metabolism is regulated in part by growth factor and cytokine regulatory effects on chondrocyte NPP1 expression.
Gene_expression (expression) of NPP1 in chondrocyte associated with cytokine
7) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.63 Pain Relevance 0.14
Interestingly, the inflammatory cytokine IL-1 depresses NPP1 expression, NPP activity, and extracellular PPi in chondrocytes [43].
Gene_expression (expression) of NPP1 in chondrocytes associated with inflammation and cytokine
8) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.98 Pain Relevance 0.28
Therefore, acquired regional and systemic decrements in NPP1 and ANK expression and extracellular PPi could contribute to intra-arterial chondroosseous metaplasia and calcification in aging, diabetes mellitus, and atherosclerosis.
Gene_expression (expression) of NPP1 associated with calcification, aging, diabetes mellitus, metaplasia and increased venous pressure under development
9) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.12 Pain Relevance 0
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Gene_expression (expression) of NPP1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
10) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.65 Pain Relevance 0.28
Osteoblasts and chondrocytes have particularly high levels of both NPP1 expression and NPP specific activity [19, 46, 47].
Gene_expression (expression) of NPP1 in chondrocytes
11) Confidence 0.78 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.69 Pain Relevance 0.11
Nevertheless, the remarkable phenotypic similarities between NPP1-deficient and ANK-deficient mice strongly support the central role of NPP1 catalyzed PPi generation in the regulation of calcification.



Gene_expression (deficient) of NPP1 associated with calcification
12) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.38 Pain Relevance 0
The MVs, are enriched in NPP1 and TNAP, whose catalytic domains are predominantly exposed at the external face of MVs.
Gene_expression (exposed) of NPP1 in face
13) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.40 Pain Relevance 0
Depending on cartilage ATP and PPi concentrations, and the level of activity of Pi-generating ATPases and pyrophosphatases, NPP1 excess promotes both HA and CPPD crystal formation by articular chondrocytes [12, 29–31], an event that commonly occurs in the joint in human aging and osteoarthritis (OA) [32].
Gene_expression (excess) of NPP1 in cartilage associated with aging and osteoarthritis
14) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.87 Pain Relevance 0.20
, and IL-1) can regulate the NPP1 content, NPP and alkaline phosphatase activities, PPi content, and other compositional features of MVs [29].
Gene_expression (content) of NPP1
15) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.43 Pain Relevance 0.05
NPP1 and ANK in PPi metabolism and calcification
Gene_expression (metabolism) of NPP1 associated with calcification
16) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0
NPP1 and PPi metabolism in cartilage and bone
Gene_expression (metabolism) of NPP1 in cartilage
17) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.52 Pain Relevance 0.11
Interestingly, periarticular and bone abnormalities are far more substantial and progressive in NPP1-deficient mice than in NPP1-deficient humans with GACI.
Gene_expression (progressive) of NPP1 associated with congenital anomalies
18) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.82 Pain Relevance 0.26
NPP1 and PPi metabolism in pathologic soft tissue calcification syndromes and pivotal role of osteopontin depletion
Gene_expression (metabolism) of NPP1 associated with calcification and syndrome
19) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.88 Pain Relevance 0.07
The initial implication of NPP1 deficiency in spontaneous pathologic soft tissue calcification was in ‘tiptoe walking’ ttw/ttw mice, which are homozygous for a spontaneous nonsense mutation that encodes for a stop codon at tyrosine 568, a position 3?
Gene_expression (deficiency) of NPP1 associated with calcification
20) Confidence 0.67 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.79 Pain Relevance 0

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