INT80222

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 82
Total Number 86
Disease Relevance 69.16
Pain Relevance 13.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
lung 4
neuronal 4
MDA-MB-231 2
brain 1
Thyroid 1
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 34 99.92 Very High Very High Very High
COX-2 inhibitor 464 99.84 Very High Very High Very High
rheumatoid arthritis 212 99.74 Very High Very High Very High
Infliximab 76 99.68 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
COX2 3 99.56 Very High Very High Very High
cOX1 1 99.56 Very High Very High Very High
Etanercept 71 99.52 Very High Very High Very High
Paracetamol 27 99.48 Very High Very High Very High
Morphine 120 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 2705 100.00 Very High Very High Very High
Cancer 1257 100.00 Very High Very High Very High
Death 290 100.00 Very High Very High Very High
Mycosis Fungoides 34 100.00 Very High Very High Very High
Lymphatic System Cancer 32 100.00 Very High Very High Very High
Brain Injury 78 99.92 Very High Very High Very High
Rheumatoid Arthritis 214 99.74 Very High Very High Very High
Neurodegenerative Disease 33 99.72 Very High Very High Very High
Infection 226 99.70 Very High Very High Very High
Skin Cancer 59 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apoptotic signal transduction pathway commonly induced by anticancer agents is associated with the induction of Bax and cleaved PARP, and the downregulation of Bcl-2 and pAkt.
Negative_regulation (downregulation) of Bcl-2 associated with apoptosis
1) Confidence 0.58 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.68 Pain Relevance 0
These results indicate that downregulation of Bcl-2 by AS Bcl-2 ODNs in breast cancer cells that normally overexpress Bcl-2 enhances their drug sensitivity, especially the sensitivity to DOX and taxanes.


Negative_regulation (downregulation) of Bcl-2 associated with breast cancer
2) Confidence 0.58 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.10 Pain Relevance 0
These results indicate that downregulation of Bcl-xL by AS Bcl-xL enhances drug sensitivity, but not to the same extent as downregulation of Bcl-2.
Negative_regulation (downregulation) of Bcl-2
3) Confidence 0.58 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0 Pain Relevance 0
Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2.
Negative_regulation (down-regulation) of Bcl-2 in B16-F10 associated with qutenza, skin cancer and apoptosis
4) Confidence 0.55 Published 2007 Journal Food Chem. Toxicol. Section Title Doc Link 17306913 Disease Relevance 0.38 Pain Relevance 0.82
Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity.
Negative_regulation (downregulate) of Bcl-2 associated with paracetamol, hepatotoxicity and cox1
5) Confidence 0.49 Published 2008 Journal Dig. Dis. Sci. Section Title Doc Link 18373199 Disease Relevance 0.55 Pain Relevance 0.88
Although AS therapy targeting Bcl-2 and Bcl-xL enhances chemosensitivity in breast cancer cells, the effect of blocking Bcl-2 seems superior to that of Bcl-xL.
Negative_regulation (blocking) of Bcl-2 in superior associated with breast cancer
6) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 1.06 Pain Relevance 0
Although our results indicate that greater suppression of Bcl-2 than Bcl-xL was achieved, the in vitro and in vivo data obtained in this study suggest that differences in Bcl-2 and Bcl-xL suppression do not fully explain their differing effects on chemosensitivity.
Negative_regulation (suppression) of Bcl-2
7) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.53 Pain Relevance 0
Although AS Bcl-2 ODNs induced splenomegaly and increased serum IL-12 levels in the present experiment, suggesting an immunostimulatory effect of AS Bcl-2, the antitumor effect of AS Bcl-2 ODNs seemed to result from downregulation of Bcl-2, independently of CpG-mediated immune stimulation.


Negative_regulation (downregulation) of Bcl-2 associated with splenomegaly
8) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.52 Pain Relevance 0
AS Bcl-2-mediated downregulation of Bcl-2 augments anticancer drug-induced signal transduction pathways leading to apoptosis, which is associated with the activation of proapoptotic proteins such as Bax and the suppression of antiapoptotic proteins such as Bcl-2 and pAkt.
Negative_regulation (suppression) of Bcl-2 associated with apoptosis
9) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.86 Pain Relevance 0
In the present study we examined the effects of downregulation of Bcl-2 and Bcl-xL on the chemosensitivity of breast cancer cells in vitro and in vivo with the aim of using this approach as a specific targeting therapy.
Spec (examined) Negative_regulation (downregulation) of Bcl-2 associated with breast cancer
10) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.70 Pain Relevance 0
Downregulation of Bcl-2 is associated with enhancement of chemosensitivity to agents such as DOX and taxanes.
Negative_regulation (Downregulation) of Bcl-2
11) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 1.00 Pain Relevance 0
This occurred in the setting of increased Bax and cleaved poly(ADP-ribose) polymerase, as well as decreased Bcl-2 and pAkt.
Negative_regulation (decreased) of Bcl-2 in poly
12) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1410745 Disease Relevance 0.36 Pain Relevance 0
However, the maximum inhibition of 70% for Bcl-2 protein was also observed at 1.0 ?
Negative_regulation (inhibition) of Bcl-2
13) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.06 Pain Relevance 0
There was a > or = 50% decrease in beta-catenin (P = 0.001) and diminishing Bcl-2 (P = 0.019) in small intestinal tumors harvested between 2 and 4 days of treatment when compared with untreated controls.
Negative_regulation (decrease) of Bcl-2 associated with intestinal cancer
14) Confidence 0.42 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.95 Pain Relevance 0.27
There was a > or = 50% decrease in beta-catenin (P = 0.001) and diminishing Bcl-2 (P = 0.019) in small intestinal tumors harvested between 2 and 4 days of treatment when compared with untreated controls.
Negative_regulation (diminishing) of Bcl-2 associated with intestinal cancer
15) Confidence 0.42 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.93 Pain Relevance 0.26
These findings suggest, but do not prove, an involvement of the alternative pathway of complement activation in regulating neuronal apoptosis after TBI by suppression of Bcl-2 and induction of Fas receptor expression in the injured brain.
Negative_regulation (suppression) of Bcl-2 in brain associated with neurodegenerative disease and brain injury
16) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 1.01 Pain Relevance 0.06
Fhit and bcl2 cases showed either all positive or all negative cells and were scored accordingly.


Negative_regulation (scored) of bcl2
17) Confidence 0.36 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.22 Pain Relevance 0
Bcl-2 levels were substantially reduced in the lung tissues from zymosan-administered mice (Figure 16B, see densitometric analysis Figure 16B1).
Negative_regulation (reduced) of Bcl-2 in lung
18) Confidence 0.31 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.30 Pain Relevance 0
On the basis of our previous findings in the mutant cartilage growth plate, where BiP was significantly upregulated and Bcl-2 was downregulated (20) owing to the expression of mutant Comp T585M, we considered the possibility that the expression of mutant Comp T585M was eliciting an rER/cell stress response in tenocytes that might eventually be causing increased cell death.
Negative_regulation (downregulated) of Bcl-2 in growth plate associated with stress and death
19) Confidence 0.27 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.69 Pain Relevance 0
Posttraumatic neuronal apoptosis has been shown to be promoted by the Fas-mediated extrinsic pathway and by a suppression of the mitochondrial anti-apoptotic mediator Bcl-2 of the intrinsic pathway of apoptosis [48-54].
Negative_regulation (suppression) of Bcl-2 in neuronal associated with apoptosis and neurodegenerative disease
20) Confidence 0.27 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 1.03 Pain Relevance 0.08

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