INT80223

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 128
Total Number 132
Disease Relevance 77.71
Pain Relevance 17.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 8
macrophages 4
intestine 2
epithelial cells 2
plasma 1
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 84 99.70 Very High Very High Very High
COX-2 inhibitor 73 99.70 Very High Very High Very High
Paracetamol 51 99.52 Very High Very High Very High
ischemia 424 99.46 Very High Very High Very High
tolerance 357 99.42 Very High Very High Very High
Inflammation 1670 99.40 Very High Very High Very High
cytokine 374 99.36 Very High Very High Very High
Glutamate 25 99.32 Very High Very High Very High
withdrawal 68 99.28 Very High Very High Very High
Antinociceptive 25 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1041 100.00 Very High Very High Very High
Shock 106 100.00 Very High Very High Very High
Infection 395 99.98 Very High Very High Very High
Hypothermia 69 99.98 Very High Very High Very High
Apoptosis 467 99.96 Very High Very High Very High
Hyperplasia 11 99.88 Very High Very High Very High
Disease 961 99.84 Very High Very High Very High
Multiple Sclerosis 245 99.84 Very High Very High Very High
Atherosclerotic Plaque 28 99.84 Very High Very High Very High
Hepatitis C Virus Infection 14 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, epibatidine was able to induce haeme oxygenase-1 (HO-1).
Positive_regulation (induce) of HO-1
1) Confidence 0.68 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.26 Pain Relevance 0.32
Additionally there was no phenotypic difference in the induction of heme oxygenase-1 mRNA after acetaminophen administration.
Positive_regulation (induction) of heme oxygenase-1 associated with paracetamol
2) Confidence 0.67 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0.10
Interestingly, Attuwaybi et al. revealed that regional hypothermia induces HO-1 and protected intestine from warm I/R injury [81].
Positive_regulation (induces) of HO-1 in intestine associated with hypothermia and injury
3) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.48 Pain Relevance 0.18
Pyrrolidine dithiocarbamate (PDTC), which is used as an antioxidant and a metabolic inhibitor of a variety of biological reactions, including activation of transcription factor NF-kB, is known to induce HO-1.
Positive_regulation (induce) of HO-1
4) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.91 Pain Relevance 0.03
Likewise, the pretreatment with hemoglobin induces HO-1 and significantly reduced systemic inflammations associated with plasma concentrations of TNF?
Positive_regulation (induces) of HO-1 in plasma
5) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.79 Pain Relevance 0
Non-pharmacological induction of HO-1 is also known to be protective for intestinal I/R injury.
Positive_regulation (induction) of HO-1 associated with injury
6) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.01 Pain Relevance 0.16
Administration of a chemical inducer of HO-1, cobalt protoporphyrin (CoPP), at 24 hours prior to ischemic insult significantly reduced intestinal tissue injury due to warm I/R injury [70].
Positive_regulation (inducer) of HO-1 associated with injury
7) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.81 Pain Relevance 0
Since inducible HO-1 was discovered and found to be a stress-responsive protein with broad cytoprotective properties, interest in the HO system has been renewed and it has attracted the attention of the scientific community worldwide [8, 9].
Positive_regulation (inducible) of HO-1 associated with stress
8) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.60 Pain Relevance 0.03
On the other hand, there are several pieces of evidence that suggest that induction of endogenous HO-1 through various pharmacological approaches can ameliorate intestinal I/R injury.
Positive_regulation (induction) of HO-1 associated with injury
9) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.80 Pain Relevance 0
In contrast, the “inducible” isoform, HO-1, is a ubiquitous heat shock protein (HSP32) that is highly induced by diverse stress-related conditions [12].
Positive_regulation (induced) of HO-1 associated with stress and shock
10) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.87 Pain Relevance 0.04
In contrast, the “inducible” isoform, HO-1, is a ubiquitous heat shock protein (HSP32) that is highly induced by diverse stress-related conditions [12].
Positive_regulation (induced) of HSP32 associated with stress and shock
11) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.86 Pain Relevance 0.04
Although the beneficial roles of HO-1 are not completely understood, there is accumulating evidence that endogenous induction of HO-1 in the setting of various stressors is indispensable for the survival of organisms.
Positive_regulation (induction) of HO-1
12) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.97 Pain Relevance 0.08
Hepatotoxic doses of APAP and CCl4 increased Ho-1 and Nqo1 mRNA levels by 22- and 2.5-fold, respectively, and reduced Oatp1a1, 1a4, and Ntcp mRNA levels in liver.
Positive_regulation (increased) of Ho-1 in liver
13) Confidence 0.62 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15496496 Disease Relevance 0.15 Pain Relevance 0.22
Tamion et al. have demonstrated that intestinal IPC with four cycles of 1 min ischemia and 10 min of reperfusion induced intestinal HO-1 and significantly reduced systemic inflammatory reactions related to intestinal I/R injury.
Positive_regulation (induced) of HO-1 associated with inflammation, ischemia and injury
14) Confidence 0.58 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.39 Pain Relevance 0.21
HO-1 induction protects the intestine from I/R injury
Positive_regulation (induction) of HO-1 in intestine associated with injury
15) Confidence 0.58 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.65 Pain Relevance 0
However, there are increasing reports showing that several drugs that are already in use clinically can induce HO-1 [104].
Positive_regulation (induce) of HO-1
16) Confidence 0.58 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.71 Pain Relevance 0.18
CONCLUSIONS: The chronic use of clinically relevant doses of opioidsleads to structural kidney abnormalities, upregulates NOS, COX-2 and HO-1, and results in renal dysfunction in a murine model of cancer.


Positive_regulation (upregulates) of HO-1 in kidney
17) Confidence 0.53 Published 2007 Journal Nephron Exp. Nephrol. Section Body Doc Link 17220637 Disease Relevance 0 Pain Relevance 0
The vasoregulatory molecules iNOS, eNOS, HO-1 and COX-2 were upregulated in the kidneys.
Positive_regulation (upregulated) of HO-1
18) Confidence 0.53 Published 2007 Journal Nephron Exp. Nephrol. Section Body Doc Link 17220637 Disease Relevance 0 Pain Relevance 0
Data suggest that neuroprotection in Tg mice was, at least in part, related to the following findings: (a) constitutively up-regulated cyclic GMP and bcl-2 levels in neurons; (b) inhibition of nuclear localization of p53 protein; and (c) antioxidant action of HO-1, as detected by postischemic neuronal expression of ferritin, and decreases in iron staining and tissue lipid peroxidation.
Positive_regulation (up-regulated) of HO-1 in neuronal associated with targeted disruption
19) Confidence 0.50 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 1.70 Pain Relevance 0.14
This effect was prevented by treatment with tin protoporphyrin (SnPP, an inhibitor of HO-1 activity) administered via intraplantar 5min before the test, suggesting a main role of HO-1.
Positive_regulation (role) of HO-1
20) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.33 Pain Relevance 0.33

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