INT80224

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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 10.53
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
macrophages 2
endothelial cells 2
horns 1
liver 1
fat 1
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 288 99.60 Very High Very High Very High
Inflammatory response 39 99.48 Very High Very High Very High
Pain 19 98.92 Very High Very High Very High
Spinal cord 34 97.32 Very High Very High Very High
tolerance 87 96.80 Very High Very High Very High
Neuronal nitric oxide synthase 5 96.44 Very High Very High Very High
ischemia 27 96.32 Very High Very High Very High
cytokine 95 93.32 High High
Central nervous system 8 90.92 High High
Eae 6 90.28 High High
Disease Link Frequency Relevance Heat
Burns 38 99.68 Very High Very High Very High
INFLAMMATION 329 99.60 Very High Very High Very High
Injury 90 97.80 Very High Very High Very High
Disease 161 97.68 Very High Very High Very High
Hypoxia 6 97.16 Very High Very High Very High
Cv General 4 Under Development 3 96.68 Very High Very High Very High
Stress 171 93.52 High High
Infection 75 92.12 High High
Malaria 45 91.68 High High
Reperfusion Injury 36 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B (p65) phosphorylation was attenuated by up-regulation of HO-1 in bEnd.3 cells.


Regulation (regulation) of HO-1
1) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.12 Pain Relevance 0.03
Up-regulation of the HO-1 gene or pretreatment with an HO-1 inducer, SnCl2, attenuated angiotensin II-induced COX-2 and PG synthesis in endothelial cells [24].
Regulation (regulation) of HO-1 in endothelial cells
2) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.37 Pain Relevance 0.22
Especially, since HO-1 is regulated by at least 3 important transcription factors (NF?
Regulation (regulated) of HO-1
3) Confidence 0.30 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.08 Pain Relevance 0.08
Heme oxygenase-1 (HO-1, HSP32) is an early gene that is responsive to an array of pathological conditions including, but not limited to, hypoxia and cerebral ischemia.
Regulation (responsive) of Heme oxygenase-1 associated with cv general 4 under development, hypoxia and ischemia
4) Confidence 0.27 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 0.70 Pain Relevance 0.13
Heme oxygenase-1 (HO-1, HSP32) is an early gene that is responsive to an array of pathological conditions including, but not limited to, hypoxia and cerebral ischemia.
Regulation (responsive) of HO-1 associated with cv general 4 under development, hypoxia and ischemia
5) Confidence 0.27 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 0.70 Pain Relevance 0.13
Heme oxygenase-1 (HO-1, HSP32) is an early gene that is responsive to an array of pathological conditions including, but not limited to, hypoxia and cerebral ischemia.
Regulation (responsive) of HSP32 associated with cv general 4 under development, hypoxia and ischemia
6) Confidence 0.27 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 0.70 Pain Relevance 0.13
Works from other laboratories have shown that the up-regulation of endogenous HO-1 ameliorated inflammatory responses and/or tissue damage 44.
Regulation (regulation) of HO-1 associated with inflammatory response
7) Confidence 0.25 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.65 Pain Relevance 0.23
Although the inflammatory response was apparently aggravated in apoE4 cells, we cannot discard the possibility that this could be even more exacerbated without the up-regulation of HO-1 observed.
Regulation (regulation) of HO-1 associated with inflammatory response
8) Confidence 0.25 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 1.06 Pain Relevance 0.26
mice attempt to store rather than burn fat.

(4) An up-regulation of genes encoding key enzymatic and nonenzymatic low–molecular mass scavengers and antioxidant defense enzymes (e.g., Sod1, Prdx2 and 3, Txnip, Ephx1, Hmox1 and five components of the glutathione system) (Table 1), suggesting that Csbm/m/Xpa?

Regulation (regulation) of Hmox1 in fat associated with burns
9) Confidence 0.25 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.16 Pain Relevance 0
Even more, the expression of MCP-1 was reduced while HO-1 was up regulated by B1R antagonism, confirming previous observations from our group that showed a similar expression profile in B1KO mice [27].
Regulation (regulated) of HO-1
10) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.07 Pain Relevance 0.54
In consequence, the effect of HO-1 on COX-2 protein in vascular endothelial cells is one of significant physiological/pathological modulation.
Regulation (modulation) of HO-1 in endothelial cells
11) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.67 Pain Relevance 0.06
In contrast, transfection with adenovirus alone had no effect on HO-1 and COX-2 experssion.
Neg (no) Regulation (effect) of HO-1
12) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0
Pharmacological modulation of HO-1 levels in the brain shows promising results in models of AD and Parkinson's disease [75].
Regulation (modulation) of HO-1 in brain associated with disease
13) Confidence 0.18 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 1.09 Pain Relevance 0.32
Luteolin caused simultaneous up-regulation of four important anti-oxidant enzymes Srxn1, Blvrb, Gclm, and Hmox1.
Regulation (regulation) of Hmox1
14) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.28 Pain Relevance 0.07
Western blotting analysis showed higher HO-1 protein concentrations in apoE4 macrophages in both untreated (controls) and LPS (1 ?
Regulation (concentrations) of HO-1 in macrophages
15) Confidence 0.15 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.13 Pain Relevance 0.03
Thus, ambient UFP triggers the induction of Nrf2-regulated HO-1 in macrophages to a greater degree than ambient PM2.5 or coarse particles [61].
Regulation (regulated) of HO-1 in macrophages
16) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.15 Pain Relevance 0
One would expect that all NO donors induce HO-1 since this gene is heavily regulated by NO.
Neg (NO) Regulation (regulated) of HO-1
17) Confidence 0.12 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.08 Pain Relevance 0.07
As expected, CRIF1 overexpression reduced accumulation of both exogenous NRF2 as well as an NRF2 target gene-encoded protein HO-1 (Fig. 3A).
Regulation (target) of HO-1
18) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Cyclo-oxygenase-1 immunoreactivity was found in glial cells of the dorsal and ventral horns, but not in neurons.
Regulation (immunoreactivity) of Cyclo-oxygenase-1 in horns
19) Confidence 0.06 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.26 Pain Relevance 0.54
The concurrent up-regulation of CYP2a5 (Figure 1B) and HO-1 (Figure 7) in the liver of P.berghei-infected DBA-2 mice is consistent with the idea advanced by Abu-Bakar et al [10] that CYP2a5 takes part in the catabolism of bilirubin, and that coordinated induction of both oxidases results in a balance between overproduction and degradation of bilirubin in response to free haem excess.


Regulation (regulation) of HO-1 in liver
20) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.66 Pain Relevance 0

General Comments

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