INT80228

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 68
Total Number 91
Disease Relevance 62.88
Pain Relevance 14.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 13
bowel 12
macrophages 10
neurons 5
lung 3
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 332 100.00 Very High Very High Very High
Spinal cord 10 100.00 Very High Very High Very High
qutenza 12 99.98 Very High Very High Very High
Morphine 9 99.98 Very High Very High Very High
Demyelination 24 99.92 Very High Very High Very High
Antinociceptive 18 99.84 Very High Very High Very High
Glutamate 16 99.72 Very High Very High Very High
Paracetamol 17 99.60 Very High Very High Very High
Inflammation 1331 99.40 Very High Very High Very High
withdrawal 64 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 539 100.00 Very High Very High Very High
Shock 103 100.00 Very High Very High Very High
Spinal Cord Injury 6 100.00 Very High Very High Very High
Apoptosis 477 99.96 Very High Very High Very High
Demyelinating Disease 172 99.92 Very High Very High Very High
Fever 44 99.90 Very High Very High Very High
Injury 1337 99.88 Very High Very High Very High
Atherosclerotic Plaque 12 99.84 Very High Very High Very High
Targeted Disruption 106 99.78 Very High Very High Very High
Multiple Sclerosis 70 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to investigate, using transgenic (Tg) mice, whether overexpression of HO-1 in the brain augments or attenuates cellular injury caused by ischemic stroke.
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of HO-1 in brain associated with targeted disruption, stroke and injury
1) Confidence 0.70 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 1.27 Pain Relevance 0.20
Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of heme oxygenase-1 in middle cerebral artery associated with targeted disruption and middle cerebral artery infarction
2) Confidence 0.70 Published 1999 Journal J. Neurochem. Section Title Doc Link 10037492 Disease Relevance 1.36 Pain Relevance 0.18
Morphine promoted expression of HO-1 in murine macrophages.
Positive_regulation (promoted) of Gene_expression (expression) of HO-1 in macrophages associated with morphine
3) Confidence 0.69 Published 2003 Journal J. Infect. Dis. Section Abstract Doc Link 12508145 Disease Relevance 0.29 Pain Relevance 0.37
Previous results from our laboratory demonstrated that HO-1 overexpression has an antinociceptive effect in the formalin test.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HO-1 associated with antinociceptive
4) Confidence 0.68 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.25 Pain Relevance 0.33
So, the aim of this study was to investigate the effect of HO-1 overexpression induced by epibatidine in nociception elicited by formalin injection in the mice hindpaw.
Spec (investigate) Positive_regulation (overexpression) of Gene_expression (overexpression) of HO-1 associated with nociception
5) Confidence 0.68 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.33 Pain Relevance 0.31
Western blot analysis also revealed that CoPP treatment induced a similar 20-fold increase in HO-1 expression in the paw; this effect was attenuated in knockout mice for Nrf2.
Positive_regulation (increase) of Gene_expression (expression) of HO-1 in paw associated with targeted disruption
6) Confidence 0.67 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.55 Pain Relevance 0.23
In this regard, HO-1 overexpression can be achieved by either exogenously administration of HO-1 or enhancement of endogenous HO-1.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HO-1
7) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.67 Pain Relevance 0
Attuwaybi et al. showed that treatment with Hemin (50 µmol/kg, subcutaneously) 2 hours prior to warm I/R injury resulted in increased HO-1 protein expression, reduced mucosal injury, decreased myeloperoxidase (MPO) activity, and improved intestinal transit following gut I/R [68].
Positive_regulation (increased) of Gene_expression (expression) of HO-1 protein in gut associated with injury and urological neuroanatomy
8) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.85 Pain Relevance 0
Interestingly, AC markedly upregulated hepatic HO-1 expression in CCl4-treated mice, which might provide anti-oxidative activity in the liver.
Positive_regulation (upregulated) of Gene_expression (expression) of HO-1 in liver
9) Confidence 0.63 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.46 Pain Relevance 0.09
To further confirm the effect of HO-1 overexpression induced by CoPP on LPS-mediated responses, bEnd.3 cells were transfected with either adenovirus or recombinant adenovirus carrying the human HO-1 (Adv-HO-1).
Positive_regulation (overexpression) of Gene_expression (overexpression) of HO-1
10) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0
These data suggest that overexpression of HO-1 exerts an inhibitory effect on COX-2 expression and PGs production in different cell types.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HO-1
11) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.45 Pain Relevance 0.23
These results suggested that overexpression of HO-1 by pretreatment with CoPP or transfection with adv-HO-1 attenuated LPS-induced COX-2 expression, at least in part, mediated through an HO-1 byproduct, CO.


Positive_regulation (overexpression) of Gene_expression (overexpression) of HO-1
12) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0
g/ml of LPS damaged the pAEC and also induced HO-1 protein expression to defend against the injury insults.
Positive_regulation (induced) of Gene_expression (expression) of HO-1 associated with injury
13) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.72 Pain Relevance 0.13
As shown in Figure 3A, pretreatment with CoPP (an HO-1 inducer) induced HO-1 protein expression in a concentration-dependent manner in bEnd.3 cells.
Positive_regulation (induced) of Gene_expression (expression) of HO-1
14) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.18 Pain Relevance 0.05
In conclusion, Nrf2-mediated HO-1 expression induced an antinociceptive effect at peripheral sites.
Positive_regulation (induced) of Gene_expression (expression) of HO-1 associated with antinociceptive
15) Confidence 0.48 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.49 Pain Relevance 0.39
Whole body hyperthermia to a core temperature of 42–43°C for 15 min significantly induced the production of heat shock protein-70 (HSP70) and HO-1 in intestinal mucosa and significantly reduced I/R-induced mucosal injury.
Positive_regulation (induced) of Gene_expression (production) of HO-1 in body associated with injury, shock and fever
16) Confidence 0.48 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.54 Pain Relevance 0.19
Poss and Tonegawa generated HO-1 deficient mice by targeted deletion of the mouse HO-1 gene.
Positive_regulation (generated) of Gene_expression (deletion) of HO-1 gene
17) Confidence 0.48 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.16 Pain Relevance 0.09
The combination of zinc protoporphyrin (ZnPP, an HO-1 inhibitor) with hyperthermia extinguished the protective effects of hyperthermia on I/R injury, suggesting that the protective effects of hyperthermia are mediated by HO-1 expression [80].
Positive_regulation (mediated) of Gene_expression (expression) of HO-1 associated with injury and fever
18) Confidence 0.48 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.50 Pain Relevance 0.16
Homozygous HO-1 Tg mice that overexpress HO-1 under the control of the neuron-specific enolase promoter (characterized previously) were used.
Positive_regulation (overexpress) of Gene_expression (overexpress) of HO-1 in neuron associated with targeted disruption
19) Confidence 0.47 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 1.49 Pain Relevance 0.22
Although the mechanisms underlying the protective actions of IPC have not been fully elucidated, recent evidence has suggested that the protective effects of ischemic preconditioning are attributable to expression of HO-1 [78, 79].
Positive_regulation (attributable) of Gene_expression (expression) of HO-1
20) Confidence 0.45 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.19 Pain Relevance 0.21

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