INT80251

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Context Info
Confidence 0.30
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 8.24
Pain Relevance 11.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 2
respiratory 2
macrophages 1
plasma 1
postsynaptic membrane 1
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 7 100.00 Very High Very High Very High
Neurotransmitter 46 99.96 Very High Very High Very High
opioid receptor 336 99.68 Very High Very High Very High
Serotonin 44 99.68 Very High Very High Very High
Inflammation 24 99.56 Very High Very High Very High
Spinal cord 37 99.32 Very High Very High Very High
nMDA receptor 117 99.12 Very High Very High Very High
qutenza 8 99.06 Very High Very High Very High
Lasting pain 24 98.76 Very High Very High Very High
Physical dependence 30 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 29 99.56 Very High Very High Very High
Targeted Disruption 145 98.96 Very High Very High Very High
Drug Dependence 30 98.56 Very High Very High Very High
Diabetic Neuropathy 4 98.36 Very High Very High Very High
Pain 144 98.32 Very High Very High Very High
Obsessive-compulsive Disorder 4 98.04 Very High Very High Very High
Hyperaesthesia 1 97.76 Very High Very High Very High
Injury 78 97.32 Very High Very High Very High
Hyperalgesia 16 97.04 Very High Very High Very High
Nociception 45 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, they have shown that the protection obtained by the inhibition of nNOS is as potent as the exogenous administration of NO and that of IP, effects that are species-independent.
nNOS Neg (inhibition) Binding (inhibition) of
1) Confidence 0.30 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.71 Pain Relevance 0.09
Besides NMDARs and nNOS, PSD-93 binds to other postsynaptic membrane proteins, such as potassium channels [9,10], ?
nNOS Binding (binds) of in postsynaptic membrane associated with potassium channel
2) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.97 Pain Relevance 1.38
It is known that nNOS and eNOS, though found primarily within the nervous system and endothelial tissue respectively, are also found in other tissues, whereas iNOS is expressed in various cell types, such as macrophages and neutrophils [6].
nNOS Binding (found) of in neutrophils
3) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 1.04 Pain Relevance 0.56
Ca2+-CaM then increases and activates CaMKII (13) that, in turn, acts on nNOS Ser847 to reduce Ca2+-CaM binding and NO production (14).
nNOS Binding (binding) of
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.42
The binding of inactive Akt and nNOS to the MOR also involves the HINT1 protein.
nNOS Binding (binding) of associated with opioid receptor
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.17 Pain Relevance 1.11
The activation of the Akt-nNOS pathway was also reduced by the binding of these proteins to the MOR-HINT1 complex where they remained inactive.
nNOS Binding (binding) of associated with opioid receptor
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.09
Given that inhibition of nNOS attenuates the development of persistent pain and morphine analgesic tolerance and physical dependence [34,35], it is very likely that the dissociation of NMDARs from NO signaling caused by PSD-93 deletion is also involved in the mechanism underlying impairing persistent pain and morphine analgesic tolerance and physical dependence in the KO mice.
nNOS Neg (inhibition) Binding (inhibition) of associated with targeted disruption, pain, physical dependence, analgesic, lasting pain, tolerance and morphine
7) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 1.02 Pain Relevance 1.29
KLYP956 thus represents the first nonimidazole-based inhibitor of iNOS and nNOS dimerization and provides a novel pharmaceutical alternative to previously described substrate competitive inhibitors.
nNOS Binding (dimerization) of
8) Confidence 0.26 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19364813 Disease Relevance 0.29 Pain Relevance 0.22
It is proposed that the amphibian peptides inhibit nNOS by interacting with Ca(2+)calmodulin, and as a consequence, blocks the attachment of this protein to the calmodulin domain of nNOS.
nNOS Binding (attachment) of
9) Confidence 0.25 Published 2002 Journal Eur. J. Biochem. Section Abstract Doc Link 11784303 Disease Relevance 0 Pain Relevance 0.04
The precise protein interactions between HINT1 and Akt or nNOS are presently being explored.
nNOS Binding (interactions) of
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.16 Pain Relevance 1.03
Synaptic elimination, glial reaction and MHC expression are not influenced by neuronal nitric oxide synthase isoform (nNOS)
nNOS Binding (nitric) of in neuronal associated with neuronal nitric oxide synthase
11) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.06 Pain Relevance 0.13
Besides alteration in the levels of neurotransmitter, alteration in the neuronal nitric oxide synthase (nNOS) is a key factor in the pathogenesis of diabetic neuropathy.
nNOS Binding (alteration) of in neuronal associated with neurotransmitter, diabetic neuropathy and neuronal nitric oxide synthase
12) Confidence 0.21 Published 2004 Journal Pharmacology Section Abstract Doc Link 15452368 Disease Relevance 1.43 Pain Relevance 0.71
We investigated the effects of substance P (SP) and neurokinin A (NKA) infusion and acute stimulation of capsaicin-sensitive sensory nerves fibers (CAP) on lung recruitment of neuronal nitric oxide synthase (nNOS)-positive inflammatory and respiratory epithelial (RE) cells in guinea-pigs.
neuronal nitric oxide synthase Binding (recruitment) of in respiratory associated with inflammation, qutenza, neuronal nitric oxide synthase and substance p
13) Confidence 0.20 Published 2008 Journal Respir Physiol Neurobiol Section Abstract Doc Link 17897889 Disease Relevance 0.10 Pain Relevance 0.50
We investigated the effects of substance P (SP) and neurokinin A (NKA) infusion and acute stimulation of capsaicin-sensitive sensory nerves fibers (CAP) on lung recruitment of neuronal nitric oxide synthase (nNOS)-positive inflammatory and respiratory epithelial (RE) cells in guinea-pigs.
nNOS Binding (recruitment) of in respiratory associated with inflammation, qutenza, neuronal nitric oxide synthase and substance p
14) Confidence 0.20 Published 2008 Journal Respir Physiol Neurobiol Section Abstract Doc Link 17897889 Disease Relevance 0.10 Pain Relevance 0.50
Alternatively, nNOS may physically interact with the serotonin transporter in such a way as to reduce its cell surface expression, which should increase extracellular serotonin levels (Chanrion et al., 2007).


nNOS Binding (interact) of associated with serotonin
15) Confidence 0.14 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.17 Pain Relevance 0.47
In addition to phosphorylation, nNOS activity or its location may be influenced by interactions with a number of proteins (Rodriguez-Crespo et al., 1998; Billecke et al., 2002; Jaffrey et al., 2002; Dreyer et al., 2004) but additional work is needed to clarify their functional significance.
nNOS Binding (interactions) of
16) Confidence 0.14 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.08 Pain Relevance 0.17
A scenario for efficacious NO generation, therefore, would be in a recently activated synapse where calmodulin with two Ca2+ bound is already associated with nNOS.
nNOS Binding (associated) of in synapse
17) Confidence 0.13 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.15
Recent evidence indicates that nNOS can bind to the serotonin transporter in the plasma membrane such that serotonin uptake then couples to NO formation (Chanrion et al., 2007), a hitherto unique ‘metabotropic’ transporter activity (Garthwaite, 2007).
nNOS Binding (bind) of in plasma associated with serotonin
18) Confidence 0.13 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.07 Pain Relevance 0.18
Both NOS-I appear to directly interact with the nAChR in the open as well as in the closed conformation.
NOS-I Binding (interact) of
19) Confidence 0.11 Published 1998 Journal Toxicol. Lett. Section Abstract Doc Link 10049129 Disease Relevance 0 Pain Relevance 0.09
Moreover, NOS-I interact directly with receptor proteins.
NOS-I Binding (interact) of
20) Confidence 0.11 Published 1998 Journal Toxicol. Lett. Section Abstract Doc Link 10049129 Disease Relevance 0 Pain Relevance 0.10

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