INT80257

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 0.74
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OXA1L) protein complex assembly (OXA1L) protein complex (OXA1L)
Anatomy Link Frequency
aorta 1
ARPE-19 1
OXA1L (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain score 2 95.02 Very High Very High Very High
Inflammation 13 94.04 High High
rheumatoid arthritis 3 87.96 High High
cINOD 5 86.96 High High
adenocard 2 45.92 Quite Low
Multiple sclerosis 2 30.72 Quite Low
anesthesia 4 25.00 Low Low
Migraine 2 18.88 Low Low
Pain 2 14.40 Low Low
fibrosis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 94.90 High High
INFLAMMATION 15 94.04 High High
Sprains And Strains 1 90.08 High High
Rheumatoid Arthritis 3 87.96 High High
Cytomegalovirus Infection 2 79.40 Quite High
Cirrhosis 110 70.52 Quite High
Disorders Of Creatine Metabolism 4 48.56 Quite Low
Demyelinating Disease 2 30.72 Quite Low
Autism 2 29.12 Quite Low
Disease 12 28.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several lymphatic drainage pathways existed defined by elevated 125I-HSA in the middle and caudal mediastinal, intercostal, and the cardiac nodes located near the root of the aorta.
Positive_regulation (elevated) of HSA in aorta
1) Confidence 0.40 Published 1999 Journal Microvasc. Res. Section Abstract Doc Link 10049665 Disease Relevance 0 Pain Relevance 0
Since we speculated that these drugs could also act by protecting endogenous proteins against denaturation, we evaluated their effect on heat-induced denaturation human serum albumin (HSA) in comparison with several fatty acids which are known to be potent stabilizers of this protein.
Positive_regulation (heat-induced) of HSA
2) Confidence 0.39 Published 2001 Journal Arch. Pharm. Res. Section Abstract Doc Link 11339635 Disease Relevance 0.34 Pain Relevance 0.40
The protein domains and the amino acid residues likely to be responsible for the hydrolytic activity of HSA were deduced from the results of various investigations: competition with probes specific of binding sites, effects of pH and of chemical modifications of albumin.
Positive_regulation (responsible) of HSA
3) Confidence 0.39 Published 2000 Journal Chirality Section Abstract Doc Link 10637410 Disease Relevance 0 Pain Relevance 0.08
pSOD-encapsulated HSA NP was prepared using a modified desolvation-crosslinking method [28].
Positive_regulation (encapsulated) of HSA
4) Confidence 0.21 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0.08 Pain Relevance 0
Safety of HSA NP as a gene delivery vector was evaluated by determining its cytotoxicity in ARPE-19 cells using MTT assay.
Positive_regulation (Safety) of HSA in ARPE-19
5) Confidence 0.19 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
The objective of these two studies was to compare the safety, tolerability, pharmacokinetics, and pain score at the subcutaneous (sc) injection site of a phosphate-buffered recombinant human erythropoietin (EPREX, epoetin alfa, r-HuEPO) formulated with a new stabilizer (glycine and Polysorbate 80) with the commercially available EPREX formulations, which uses human serum albumin (HSA) as the stabilizer.
Positive_regulation (uses) of HSA associated with pain score
6) Confidence 0.18 Published 2000 Journal Biopharm Drug Dispos Section Abstract Doc Link 11304719 Disease Relevance 0.09 Pain Relevance 0.10
M6PHSA HSA was modified with mannose-6-phosphate groups as described (4).
Positive_regulation (modified) of HSA
7) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.23 Pain Relevance 0
Seven out of eight sera with IgG reactivity against modified food antigens showed significant elevation against AGE-HSA, AGE-Hb, ox-LDL and MBP (Table 2).
Positive_regulation (elevation) of HSA
8) Confidence 0.02 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2685801 Disease Relevance 0 Pain Relevance 0
For example, Sample #4 with IgG immune reaction against 16 out of 45 modified food antigens showed simultaneous elevation in antibodies against AGE-HSA (120 EU), AGE-Hb (111 EU), ox-LDL (2,431 mU) and MBP (129 EU).
Positive_regulation (elevation) of HSA
9) Confidence 0.02 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2685801 Disease Relevance 0 Pain Relevance 0

General Comments

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