INT8027

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 7
Speculated 18
Reported most in Abstract
Documents 34
Total Number 52
Disease Relevance 26.32
Pain Relevance 31.16

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signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 32
dorsal root ganglia 9
spinal cord 6
TMJ 6
brain 4
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 993 100.00 Very High Very High Very High
Spinal cord 133 100.00 Very High Very High Very High
Calcitonin gene-related peptide 76 100.00 Very High Very High Very High
Neuropeptide 42 100.00 Very High Very High Very High
cytokine 29 100.00 Very High Very High Very High
Hippocampus 23 100.00 Very High Very High Very High
antagonist 19 100.00 Very High Very High Very High
opiate 5 100.00 Very High Very High Very High
Trk A 5 100.00 Very High Very High Very High
trigeminal ganglion 8 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 22 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Cancer 10 100.00 Very High Very High Very High
Stress Incontinence 5 100.00 Very High Very High Very High
Metabolic Syndrome 4 100.00 Very High Very High Very High
Neuroleptic Malignant Syndrome 22 99.98 Very High Very High Very High
Cystitis 10 99.98 Very High Very High Very High
Tooth Injuries 2 99.84 Very High Very High Very High
Inflammatory Bowel Disease 2 99.60 Very High Very High Very High
Intracranial Hypertension 18 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also analyzed changes in the expression of nerve growth factor (NGF), which is involved in plasticity of the nociceptive circuit after nerve injury.
Spec (analyzed) Regulation (changes) of Gene_expression (expression) of nerve growth factor in nerve associated with nociception, nervous system injury and nerve growth factor
1) Confidence 0.62 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18165597 Disease Relevance 0.55 Pain Relevance 0.79
These observations not only suggest regulation of skin NGF biosynthesis by afferent neuronal and adrenergic mechanisms, but also indicate possible targets for pharmacological modulation of skin NGF biosynthesis.
Spec (possible) Regulation (modulation) of Gene_expression (biosynthesis) of NGF in neuronal associated with nerve growth factor
2) Confidence 0.62 Published 2004 Journal Pain Section Abstract Doc Link 15494187 Disease Relevance 0 Pain Relevance 0.85
These observations not only suggest regulation of skin NGF biosynthesis by afferent neuronal and adrenergic mechanisms, but also indicate possible targets for pharmacological modulation of skin NGF biosynthesis.
Regulation (regulation) of Gene_expression (biosynthesis) of NGF in neuronal associated with nerve growth factor
3) Confidence 0.62 Published 2004 Journal Pain Section Abstract Doc Link 15494187 Disease Relevance 0 Pain Relevance 0.99
For sensory neurons, increased levels of NGF and GDNF do not affect the number of regenerated neurons 1 cm distal to a lesion at 4 weeks post-lesion but do cause changes in the expression of markers for different populations of nociceptive neurons.
Neg (not) Regulation (affect) of Gene_expression (levels) of NGF in sensory neurons associated with nociception and nerve growth factor
4) Confidence 0.61 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.25 Pain Relevance 0.25
The CB1093 did not affect expression of nerve growth factor receptors (trkA and p75(NTR)) in dorsal root ganglia in control or diabetic rats, though the p75(NTR) expression was reduced by diabetes.
Neg (not) Regulation (affect) of Gene_expression (expression) of nerve growth factor in dorsal root ganglia
5) Confidence 0.61 Published 1999 Journal Diabetologia Section Body Doc Link 10550414 Disease Relevance 0 Pain Relevance 0
Coexpression of semaphorin3A and NGF at moderate to low concentrations within the adult spinal cord reduced sprouting of calcitonin gene-related peptide and substance P-containing axons compared with GFP and NGF coexpression controls.
Regulation (controls) of Gene_expression (coexpression) of NGF in spinal cord associated with substance p, calcitonin gene-related peptide and spinal cord
6) Confidence 0.61 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749426 Disease Relevance 0.66 Pain Relevance 0.63
The mechanism of these effects is unknown, but may involve changes in the expression of nerve growth factor, which is reduced by opioid exposure.
Spec (may) Regulation (involve) of Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor and opioid
7) Confidence 0.57 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810245 Disease Relevance 0 Pain Relevance 0.64
We have investigated whether chronic nerve growth factor (NGF) depletion affects the development of transmedian collateral reinnervation by C-fibres.
Spec (whether) Regulation (affects) of Spec (whether) Gene_expression (depletion) of nerve growth factor in nerve associated with c fibre and nerve growth factor
8) Confidence 0.45 Published 1992 Journal Brain Res. Section Abstract Doc Link 1360319 Disease Relevance 0 Pain Relevance 0.61
We also analyzed changes in the expression of nerve growth factor (NGF), which is involved in plasticity of the nociceptive circuit after nerve injury.
Spec (analyzed) Regulation (changes) of Spec (analyzed) Gene_expression (expression) of NGF in nerve associated with nociception, nervous system injury and nerve growth factor
9) Confidence 0.45 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18165597 Disease Relevance 0.55 Pain Relevance 0.79
We have investigated whether chronic nerve growth factor (NGF) depletion affects the development of transmedian collateral reinnervation by C-fibres.
Spec (whether) Regulation (affects) of Spec (whether) Gene_expression (depletion) of NGF in nerve associated with c fibre and nerve growth factor
10) Confidence 0.45 Published 1992 Journal Brain Res. Section Abstract Doc Link 1360319 Disease Relevance 0 Pain Relevance 0.61
In order to examine the relationship between the action of opioid neurotransmitters and growth factors in the regulation of brain development, we have studied the long-term effect of the opiate antagonist naltrexone (NTX) on the content of nerve growth factor (NGF) in cortex, hippocampus, septum and neostriatum, and on NGF receptor (NGFRs) levels in cortical membranes. 50 mg/kg NTX treatment induced a decrease in the number of 125I-NGF high-affinity binding sites, without detectable changes in NGF levels.
Regulation (effect) of Gene_expression (levels) of nerve growth factor in nerve associated with neurotransmitter, nerve growth factor, antagonist, hippocampus, opiate and opioid
11) Confidence 0.45 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8469378 Disease Relevance 0 Pain Relevance 0.85
In order to examine the relationship between the action of opioid neurotransmitters and growth factors in the regulation of brain development, we have studied the long-term effect of the opiate antagonist naltrexone (NTX) on the content of nerve growth factor (NGF) in cortex, hippocampus, septum and neostriatum, and on NGF receptor (NGFRs) levels in cortical membranes. 50 mg/kg NTX treatment induced a decrease in the number of 125I-NGF high-affinity binding sites, without detectable changes in NGF levels.
Regulation (effect) of Gene_expression (levels) of NGF in nerve associated with neurotransmitter, nerve growth factor, antagonist, hippocampus, opiate and opioid
12) Confidence 0.45 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8469378 Disease Relevance 0 Pain Relevance 0.85
In order to examine the relationship between the action of opioid neurotransmitters and growth factors in the regulation of brain development, we have studied the long-term effect of the opiate antagonist naltrexone (NTX) on the content of nerve growth factor (NGF) in cortex, hippocampus, septum and neostriatum, and on NGF receptor (NGFRs) levels in cortical membranes. 50 mg/kg NTX treatment induced a decrease in the number of 125I-NGF high-affinity binding sites, without detectable changes in NGF levels.
Regulation (effect) of Gene_expression (levels) of NGF in nerve associated with neurotransmitter, nerve growth factor, antagonist, hippocampus, opiate and opioid
13) Confidence 0.45 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8469378 Disease Relevance 0 Pain Relevance 0.85
The study investigated the effects of metabolic syndrome on urinary bladder nerve-growth factor (NGF) and p75(NTR) expression in fructose-fed obese rats.
Spec (investigated) Regulation (effects) of Spec (investigated) Gene_expression (expression) of nerve-growth factor in nerve associated with obesity and metabolic syndrome
14) Confidence 0.45 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18585860 Disease Relevance 0.33 Pain Relevance 0.08
The study investigated the effects of metabolic syndrome on urinary bladder nerve-growth factor (NGF) and p75(NTR) expression in fructose-fed obese rats.
Spec (investigated) Regulation (effects) of Spec (investigated) Gene_expression (expression) of NGF in nerve associated with obesity and metabolic syndrome
15) Confidence 0.45 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18585860 Disease Relevance 0.33 Pain Relevance 0.08
Hypothesising that changes of neurotrophin production in response to elevated ICP may be reflected in altered CSF concentrations of NGF and NT-3, we set out to measure these neurotrophins in children who underwent ventricular taps or shunt placement surgery for hydrocephalus.


Regulation (altered) of Gene_expression (concentrations) of NGF associated with nerve growth factor, hydrocephalus and cva
16) Confidence 0.45 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 1.37 Pain Relevance 0.38
At week 8 and 12, there were also significant differences in myelin sheath thickness between the groups of NAT-NGF and LBD-NGF (n?
Regulation (differences) of Gene_expression (groups) of NAT-NGF associated with nerve growth factor
17) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.32 Pain Relevance 0.73
The intent was to determine whether concentrations of the neuropeptide calcitonin gene-related peptide (CGRP), the neurotrophin nerve growth factor (NGF), and the proinflammatory cytokines interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNF-alpha) are altered in the trigeminal ganglion and TMJ tissues during various stages of adjuvant-induced inflammation of the rat TMJ.
Regulation (altered) of Spec (whether) Gene_expression (concentrations) of neurotrophin nerve growth factor in TMJ associated with ganglion cysts, snapping jaw, trigeminal ganglion, cytokine, calcitonin gene-related peptide, necrosis, nerve growth factor, inflammation, cancer and neuropeptide
18) Confidence 0.45 Published 2005 Journal J Orofac Pain Section Abstract Doc Link 15779537 Disease Relevance 1.29 Pain Relevance 0.97
The intent was to determine whether concentrations of the neuropeptide calcitonin gene-related peptide (CGRP), the neurotrophin nerve growth factor (NGF), and the proinflammatory cytokines interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNF-alpha) are altered in the trigeminal ganglion and TMJ tissues during various stages of adjuvant-induced inflammation of the rat TMJ.
Regulation (altered) of Spec (whether) Gene_expression (concentrations) of NGF in TMJ associated with ganglion cysts, snapping jaw, trigeminal ganglion, cytokine, calcitonin gene-related peptide, necrosis, nerve growth factor, inflammation, cancer and neuropeptide
19) Confidence 0.45 Published 2005 Journal J Orofac Pain Section Abstract Doc Link 15779537 Disease Relevance 1.29 Pain Relevance 0.97
NGF infusion did not significantly affect the number of HSV-immunoreactive cells (4,224 +/- 618), or the number of cells expressing beta-Gal (330 +/- 72) at this time.
Neg (not) Regulation (affect) of Gene_expression (infusion) of NGF associated with cold sores and nerve growth factor
20) Confidence 0.45 Published 1994 Journal Hum. Gene Ther. Section Abstract Doc Link 7948148 Disease Relevance 0.77 Pain Relevance 0.26

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