INT80295

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.63
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL13) extracellular space (CCL13) extracellular region (CCL13)
cytoskeleton organization (CCL13) cell-cell signaling (CCL13)
Anatomy Link Frequency
skin 2
fibroblasts 2
gray matter 1
CCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 98.68 Very High Very High Very High
Inflammation 70 97.52 Very High Very High Very High
Multiple sclerosis 60 89.72 High High
chemokine 107 86.20 High High
corticosteroid 4 84.76 Quite High
Central nervous system 50 68.16 Quite High
cytokine 21 64.72 Quite High
rheumatoid arthritis 6 51.84 Quite High
Inflammatory marker 4 50.00 Quite Low
antagonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 77 98.48 Very High Very High Very High
Neurological Disease 12 97.48 Very High Very High Very High
Encephalitis 2 95.48 Very High Very High Very High
Alzheimer's Dementia 1 94.40 High High
Parkinson's Disease 1 93.44 High High
Disease 28 91.04 High High
Rhinitis 6 90.16 High High
Demyelinating Disease 78 89.72 High High
Contact Dermatitis 56 89.28 High High
Apoptosis 5 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the promoter elements potentially regulating MCP-4 gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-2, a NF-kappaB like consensus sequence, gamma-interferon- response and YY-1 elements as well as glucocorticoid response elements.
Gene_expression (expression) of MCP-4 gene associated with inflammation and cinod
1) Confidence 0.58 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.43 Pain Relevance 0.26
Like MCP-3, MCP-4 mRNA expression in dermal fibroblasts is upregulated by TNF-alpha, IL-1alpha, IFN-gamma or IL-4 and differs from RANTES and eotaxin mRNA expression in its response to IFN-gamma and/or IL-4.
Gene_expression (expression) of MCP-4 mRNA in fibroblasts
2) Confidence 0.58 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.39 Pain Relevance 0.24
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Gene_expression (expression) of CCL13 in skin associated with inflammation
3) Confidence 0.51 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.79 Pain Relevance 0.24
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Gene_expression (expression) of MCP-4 in skin associated with inflammation
4) Confidence 0.51 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.79 Pain Relevance 0.24
We here describe the genomic organisation (3 exons of 138, 115 and 578 bp, 2 introns of 867 and 437 bp and 1.4 kb of regulatory sequences from the immediate 5' upstream region), sequence (genomic and transcribed) and mRNA expression of the human MCP-4 gene in dermal fibroblasts.
Gene_expression (expression) of MCP-4 gene in fibroblasts
5) Confidence 0.45 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.44 Pain Relevance 0.25
In consensus with others, however, we also note an increased CCL7, CCL8 and CCL13 expression in the white matter as compared to the gray matter in 5 other neurological disease controls (1 viral and 1 post-infectious encephalitis, 2 Alzheimer disease and 1 Parkinson disease).
Gene_expression (expression) of CCL13 in gray matter associated with parkinson's disease, neurological disease, alzheimer's dementia and encephalitis
6) Confidence 0.20 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.79 Pain Relevance 0.24

General Comments

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