INT80296

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.65
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL7) extracellular space (CCL7) extracellular region (CCL7)
cytoskeleton organization (CCL7) cell-cell signaling (CCL7)
Anatomy Link Frequency
immune cells 1
fibroblasts 1
CCL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 57 100.00 Very High Very High Very High
chemokine 42 100.00 Very High Very High Very High
Inflammation 134 98.36 Very High Very High Very High
cINOD 4 91.00 High High
dexamethasone 7 79.44 Quite High
Inflammatory response 12 72.28 Quite High
imagery 60 50.00 Quite Low
metalloproteinase 8 36.16 Quite Low
cva 11 16.32 Low Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 7 98.72 Very High Very High Very High
INFLAMMATION 160 98.36 Very High Very High Very High
Asthma 44 97.52 Very High Very High Very High
Atherosclerosis 111 94.72 High High
Atherosclerotic Plaque 19 93.12 High High
Cardiovascular Disease 19 88.72 High High
Rhinitis 2 75.00 Quite High
Disease 29 74.60 Quite High
Shock 1 70.48 Quite High
Hypersensitivity 3 48.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arterial SMCs, in particular, express a large set of genes that mediate these interactions—such as cytokines/chemokines (IL6, CCL8, CCL7, CCL2, CXCL1, CXCL2, CXCL3, and CXCL6), complement pathway (complement factor B [CFB]), and surface receptor (ICAM1) (Figure 3B)—suggesting that vascular SMCs may themselves mediate recruitment of immune cells to the vascular walls.
Gene_expression (express) of CCL7 in immune cells associated with chemokine and cytokine
1) Confidence 0.43 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.17 Pain Relevance 0.10
CSF-1 induced expression of the proatherogenic chemokines CXCL10/IP-10, CCL2 and CCL7 but repressed expression of the antiatherogenic chemokine receptor CXCR4 [53].
Gene_expression (expression) of CCL7 associated with chemokine
2) Confidence 0.32 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.84 Pain Relevance 0.27
Like MCP-3, MCP-4 mRNA expression in dermal fibroblasts is upregulated by TNF-alpha, IL-1alpha, IFN-gamma or IL-4 and differs from RANTES and eotaxin mRNA expression in its response to IFN-gamma and/or IL-4.
Gene_expression (expression) of MCP-3 in fibroblasts
3) Confidence 0.12 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.39 Pain Relevance 0.24
Work published by two groups describes the expression and secretion of MCP-1, MCP-2 and MCP-3 by human ASM cells treated with the pro-inflammatory cytokines TNF-?
Gene_expression (expression) of MCP-3 associated with inflammation and cytokine
4) Confidence 0.04 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.25 Pain Relevance 0.32

General Comments

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