INT80300

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.76
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TFAP2A) nucleolus (TFAP2A) nucleus (TFAP2A)
cytoplasm (TFAP2A)
Anatomy Link Frequency
placenta 1
TFAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 100.00 Very High Very High Very High
headache 1 91.24 High High
Migraine 1 90.84 High High
Inflammation 7 85.88 High High
chemokine 5 81.40 Quite High
Pain 2 61.60 Quite High
cytokine 14 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Adhesions 6 100.00 Very High Very High Very High
Breast Cancer 14 99.84 Very High Very High Very High
Cancer 159 99.46 Very High Very High Very High
Esophageal Cancer 1 95.32 Very High Very High Very High
Pancreatic Cancer 1 93.04 High High
Migraine Disorders 1 91.24 High High
Renal Cancer 55 90.84 High High
Lung Cancer 3 89.92 High High
Lymphatic System Cancer 2 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings suggest that AP-2 may be one of the important factors regulating P-LAP gene expression in human placenta.
Gene_expression (expression) of AP-2 in placenta
1) Confidence 0.54 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517297 Disease Relevance 0.13 Pain Relevance 0.06
These include the oncogenes JAZF1, AXL, ABL2; tumor suppressors RASD1, PTPRO, TFAP2A, CDKN1C; and genes involved in proteolysis or cell-adhesion such as WASF2, and PAPPA.



Gene_expression (adhesion) of TFAP2A associated with cancer and adhesions
2) Confidence 0.53 Published 2007 Journal Cancer Informatics Section Abstract Doc Link PMC2675843 Disease Relevance 0.83 Pain Relevance 0
shRNA expression vectors for 7 genes (IGF2R, SREBF2, AKAP11, TFAP2A, LHX3, TPX2 and ING1) were prepared as described [15].
Gene_expression (expression) of TFAP2A
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.17 Pain Relevance 0
Among the promoter elements potentially regulating MCP-4 gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-2, a NF-kappaB like consensus sequence, gamma-interferon- response and YY-1 elements as well as glucocorticoid response elements.
Gene_expression (expression) of AP-2 associated with inflammation and cinod
4) Confidence 0.21 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.43 Pain Relevance 0.26
It also has been shown to decrease AP-2 and YY-1 transcription factor expression in breast cancer cells and tumors [320].
Gene_expression (expression) of AP-2 associated with cancer and breast cancer
5) Confidence 0.08 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 1.20 Pain Relevance 0.27

General Comments

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