INT80302

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.67
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TFAP2A) nucleolus (TFAP2A) nucleus (TFAP2A)
cytoplasm (TFAP2A)
Anatomy Link Frequency
bands 2
proximal 1
pits 1
TFAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 99.12 Very High Very High Very High
Inflammation 1 81.48 Quite High
chemokine 3 77.00 Quite High
Pain 6 64.08 Quite High
imagery 2 42.64 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.00 Very High Very High Very High
Adhesions 16 94.52 High High
Familial Adenomatous Polyposis 12 88.04 High High
Disease 16 81.84 Quite High
Rhinitis 2 80.96 Quite High
Infection 84 74.84 Quite High
Reprotox - General 1 5 69.72 Quite High
Focal Cartilage Defect 9 64.72 Quite High
Pain 3 64.08 Quite High
Dengue 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophoretic mobility shift assays to identify the proteins interacting with DNA at FP3 revealed three retarded bands, one of which was generated by activator protein-2 (AP-2) binding.
activator protein-2 Binding (binding) of in bands
1) Confidence 0.39 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517297 Disease Relevance 0.13 Pain Relevance 0.06
Electrophoretic mobility shift assays to identify the proteins interacting with DNA at FP3 revealed three retarded bands, one of which was generated by activator protein-2 (AP-2) binding.
AP-2 Binding (binding) of in bands
2) Confidence 0.30 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517297 Disease Relevance 0.13 Pain Relevance 0.06
Among the promoter elements potentially regulating MCP-4 gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-2, a NF-kappaB like consensus sequence, gamma-interferon- response and YY-1 elements as well as glucocorticoid response elements.
AP-2 Binding (interact) of associated with inflammation and cinod
3) Confidence 0.13 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.42 Pain Relevance 0.25
1 activation of p38 MAP kinase results in the inhibition of AP-2 DNA binding, resulting in increased expression of the aggrecan gene.
AP-2 Binding (binding) of
4) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.28 Pain Relevance 0
1-induced MSC chondrogenesis, and alterations of AP-2 binding, but not Sp-1, are mediated by the activity of p38 MAP kinase [110].
AP-2 Binding (binding) of
5) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.24 Pain Relevance 0
Previous study by Benmerah et al has shown that EPS15, a protein that binds to the AP-2 adapter, is required for internalization through clathrin-coated pits [38].
AP-2 Binding (binds) of in pits
6) Confidence 0.06 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.20 Pain Relevance 0
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
AP-2 Binding (binding) of in proximal
7) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.27 Pain Relevance 0

General Comments

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