INT80305

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Context Info
Confidence 0.04
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.68
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
sciatic nerves 1
pituitary 1
IGKV2-30 (Homo sapiens)
Pain Link Frequency Relevance Heat
Demyelination 1 99.76 Very High Very High Very High
metalloproteinase 1 99.52 Very High Very High Very High
Inflammation 4 99.48 Very High Very High Very High
Sciatic nerve 1 98.60 Very High Very High Very High
Enkephalin 3 98.56 Very High Very High Very High
Neuritis 5 97.88 Very High Very High Very High
Dynorphin 3 91.76 High High
Peripheral nervous system 1 83.56 Quite High
Neuropeptide 2 25.00 Low Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 3 99.76 Very High Very High Very High
INFLAMMATION 4 99.48 Very High Very High Very High
Myopia 240 99.36 Very High Very High Very High
Experimental Autoimmune Neuritis 5 97.88 Very High Very High Very High
Immunization 1 96.60 Very High Very High Very High
Paraparesis 1 94.76 High High
Adrenal Cancer 274 88.88 High High
Polyradiculoneuropathy 1 86.72 High High
Refractive Errors 6 85.36 High High
Polycystic Ovary Syndrome 28 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When a reanalysis was performed for a subset of our families (n=74) with siblings (n=95) having more severe myopia (-8.00D or less; this is the same threshold used in the Singapore case-control study), no association could be demonstrated between MYOC microsatellites (both NGA17 and NGA19) and myopia under any genetic models tested (data not shown).
Gene_expression (microsatellites) of NGA17 associated with myopia
1) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.69 Pain Relevance 0
For the sake of consistency, alleles with 11 to 17 GT repeats were designated as alleles 1 to 7, respectively although alleles 1, 2, and 7 were not found for NGA17 and allele 2 was not identified for NGA19 in this study.
Neg (not) Gene_expression (found) of NGA17
2) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.47 Pain Relevance 0
In general, preferential nontransmission (negative Z scores) was seen in allele 5 of NGA17 and allele 3 of NGA19 while preferential transmission (positive Z scores) was noted in the other alleles (Table 3).
Gene_expression (allele) of NGA17
3) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.15 Pain Relevance 0
Detection of 17-OHP from dried whole blood spots using LC followed by tandem mass spectrometry (LC/MS/MS) has been reported [90].
Gene_expression (Detection) of 17-OHP in blood
4) Confidence 0.01 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.18 Pain Relevance 0
Hence, P4 and 17-OHP levels in these patients may remain above normal even in the presence of excessive glucocorticoid administration [41].
Gene_expression (levels) of 17-OHP
5) Confidence 0.01 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.94 Pain Relevance 0
In the brain and neurointermediate lobe of the pituitary, prodynorphin is processed to produce alpha and beta neo endorphins, dynorphins (Dyn) A-17 and Dyn A-8, Dyn B-13, and leucine-enkephalin.
Gene_expression (produce) of A-17 in pituitary associated with enkephalin
6) Confidence 0.00 Published 1999 Journal J. Biochem. Section Abstract Doc Link 10050055 Disease Relevance 0 Pain Relevance 0.22
T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment.
Gene_expression (expression) of interleukine-17 in sciatic nerves associated with demyelination, inflammation, metalloproteinase, sciatic nerve and neuritis
7) Confidence 0.00 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19804913 Disease Relevance 1.24 Pain Relevance 0.79

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