INT80316

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Context Info
Confidence 0.31
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.28
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Npy2r) plasma membrane (Npy2r) signal transducer activity (Npy2r)
Anatomy Link Frequency
neurons 1
nerves 1
Npy2r (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 14 92.88 High High
Action potential 44 91.92 High High
Sciatic nerve 1 91.80 High High
agonist 23 89.84 High High
GABAergic 18 89.20 High High
antagonist 41 79.84 Quite High
gABA 12 79.44 Quite High
Root ganglion neuron 3 75.00 Quite High
Somatostatin 22 41.68 Quite Low
Neuropathic pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 75.00 Quite High
Nervous System Injury 1 75.00 Quite High
Adhesions 1 65.04 Quite High
Obesity 1 44.96 Quite Low
Hyperinsulinism 1 31.36 Quite Low
Targeted Disruption 16 17.12 Low Low
Decapitation 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrating that Y2 receptor activation stimulated the electrical activity of identified GHRH neurons is quite provocative in this respect, since these same Y2 receptors are mandatory for an adaptation of GHRH neurons to prolonged fasting [25], [26].
Positive_regulation (activation) of Y2 receptor in neurons
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.09
Therefore, Y2 receptor activation was not required for the stimulatory effect of ghrelin.


Positive_regulation (activation) of Y2 receptor
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.30
Increased excitability was mediated via a Y2-receptor and resulted from attenuation of Ca2+-sensitive K+-conductance(s) secondary to suppression of N-type Ca2+ channel current.
Positive_regulation (mediated) of Y2-receptor
3) Confidence 0.15 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051216 Disease Relevance 0.21 Pain Relevance 0.39
NPY released from other non-adrenergic, non-cholinergic secretomotor nerves could auto-inhibit NPY release by Y2 receptor activation and local NPY, NPY(3–36), PYY, or PYY(3–36) could act on these neuronal Y2 receptors to modulate ongoing mucosal electrolyte secretion.
Positive_regulation (activation) of Y2 receptor in nerves
4) Confidence 0.08 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.07 Pain Relevance 0

General Comments

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