INT80319

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.00
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
pyramidal cell 2
dentate gyrus 2
CA1 2
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 24 100.00 Very High Very High Very High
Pyramidal cell 8 100.00 Very High Very High Very High
Morphine 6 99.98 Very High Very High Very High
antidepressant 4 99.98 Very High Very High Very High
Pain 3 99.82 Very High Very High Very High
nociceptor 2 99.82 Very High Very High Very High
narcan 1 99.82 Very High Very High Very High
fluoxetine 3 90.48 High High
corticosteroid 3 79.40 Quite High
anesthesia 2 67.04 Quite High
Disease Link Frequency Relevance Heat
Convulsion 4 99.06 Very High Very High Very High
Fever 18 98.84 Very High Very High Very High
Nociception 1 94.64 High High
Febrile Convulsions 4 56.24 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adult rat, a decrease in CA1 inhibition requires a higher degree of hyperthermia, and hippocampal seizure generation is opposed by an increase in dentate gyrus inhibition.
Negative_regulation (decrease) of Negative_regulation (inhibition) of CA1 in dentate gyrus associated with convulsion, hippocampus and fever
1) Confidence 0.59 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12205644 Disease Relevance 0.97 Pain Relevance 0.50
We suggest that hyperthermia contributes to seizure susceptibility in the immature hippocampus by decreasing CA1 inhibition.
Negative_regulation (decreasing) of Negative_regulation (inhibition) of CA1 in CA1 associated with convulsion, hippocampus and fever
2) Confidence 0.51 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12205644 Disease Relevance 0.94 Pain Relevance 0.51
Morphine reversed formalin-induced CA1 pyramidal cell suppression via an effect on septohippocampal neural processing.
Negative_regulation (reversed) of Negative_regulation (suppression) of CA1 in pyramidal cell associated with pyramidal cell and morphine
3) Confidence 0.38 Published 1999 Journal Neuroscience Section Title Doc Link 10051217 Disease Relevance 0.09 Pain Relevance 0.96
In situ hybridization histochemistry showed that the antidepressants decreased MR mRNA expression in all hippocampal subregions (e.g. 45% decrease in CA1 with venlafaxine, P<0.001), while GR mRNA expression was selectively reduced in the CA3 subregion.
Negative_regulation (decreased) of Negative_regulation (decrease) of CA1 associated with antidepressant
4) Confidence 0.26 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.61

General Comments

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