INT80339

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Context Info
Confidence 0.73
First Reported 1999
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.30
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (PHF2) nucleolus (PHF2) nucleus (PHF2)
Anatomy Link Frequency
embryos 1
MCF-7 1
PHF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 5 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 5 99.00 Very High Very High Very High
Breast Cancer 165 98.08 Very High Very High Very High
Disease 9 96.20 Very High Very High Very High
Cancer 78 93.96 High High
Hyperplasia 3 91.84 High High
Lung Cancer 3 72.40 Quite High
Skin Cancer 48 69.28 Quite High
Freckles 6 66.40 Quite High
Rheumatoid Arthritis 3 49.04 Quite Low
Basal Cell Nevus Syndrome 15 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Northern analysis shows widespread expression of PHF2 in adult tissues, while in situ hybridization on mouse embryos reveals staining in the neural tube and dorsal root ganglia significantly above a ubiquitous low level expression signal.
Gene_expression (expression) of PHF2 in embryos
1) Confidence 0.73 Published 1999 Journal Mamm. Genome Section Abstract Doc Link 10051327 Disease Relevance 0 Pain Relevance 0.08
From its expression pattern and its chromosomal localization, PHF2 is a candidate gene for hereditary sensory neuropathy type I, HSN1.
Gene_expression (expression) of PHF2 associated with hsan
2) Confidence 0.63 Published 1999 Journal Mamm. Genome Section Abstract Doc Link 10051327 Disease Relevance 0.10 Pain Relevance 0.10
Compared to XPA, overall frequencies of alterations in PHF2, FANCC and PTCH1 were higher (Figure 4).
Gene_expression (higher) of PHF2
3) Confidence 0.58 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.48 Pain Relevance 0
The mRNA expression of PHF2, FANCC, PTCH1 and XPA in normal breast tissue (n = 6), and primary BC (n = 14) and 1 cell line (MCF-7) was analyzed by quantitative real-time (Q-PCR).
Spec (analyzed) Gene_expression (expression) of PHF2 in MCF-7 associated with breast cancer
4) Confidence 0.52 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.32 Pain Relevance 0
Thus an attempt was made in this study to analyze the alterations (deletion, methylation and expression) of PHF2, FANCC, PTCH1 and XPA in early- and late-onset BC of Indian patients and correlate them with clinico-pathological differences.


Spec (analyze) Gene_expression (expression) of PHF2 associated with breast cancer
5) Confidence 0.52 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 1.39 Pain Relevance 0.08

General Comments

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