INT80344

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Context Info
Confidence 0.56
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.99
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Anatomy Link Frequency
hippocampus 2
nerve 1
cerebral cortex 1
piriform cortex 1
synapses 1
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 74 100.00 Very High Very High Very High
Morphine 28 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
fortral 5 99.64 Very High Very High Very High
Thalamus 1 99.62 Very High Very High Very High
qutenza 2 99.38 Very High Very High Very High
nociceptor 2 99.38 Very High Very High Very High
cerebral cortex 6 99.28 Very High Very High Very High
Kinase C 10 99.04 Very High Very High Very High
amygdala 1 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 3 99.56 Very High Very High Very High
Hyperalgesia 3 95.72 Very High Very High Very High
Aids-related Complex 35 93.08 High High
Neuropathic Pain 3 90.64 High High
Body Weight 1 89.96 High High
Urological Neuroanatomy 3 85.92 High High
Opiate Addiction 2 64.24 Quite High
Apoptosis 1 58.52 Quite High
INFLAMMATION 1 35.52 Quite Low
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of Ca2+/calmodulin-dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: differential regulation of alpha and beta isoforms.
Regulation (Modulation) of Ca2+/calmodulin-dependent protein kinase II in hippocampus associated with narcan, hippocampus and morphine
1) Confidence 0.56 Published 1999 Journal Mol. Pharmacol. Section Title Doc Link 10051541 Disease Relevance 0.06 Pain Relevance 0.81
However, changes of alpha-CaMK II gene levels mentioned above were not detected in amygdala or piriform cortex.
Regulation (changes) of alpha-CaMK II in piriform cortex associated with amygdala
2) Confidence 0.45 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.08 Pain Relevance 0.79
The Ca(2+)/calmodulin-dependent kinase II inhibitors 1-[N,O-bis-(5-isoquionolinesulfonyl)]-N-methyl-L-tyrosyl-4-phenylpiperazine and N-[2-[[[3-(4'-chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxy-benzenesulfonamide phosphate did not significantly affect the (+)-pentazocine-mediated enhancement of amphetamine-stimulated [(3)H]DA release.
Regulation (affect) of calmodulin-dependent kinase II associated with fortral and dopamine
3) Confidence 0.27 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11907188 Disease Relevance 0 Pain Relevance 0.71
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Regulation (modulating) of CaM kinase II in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
4) Confidence 0.26 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53
Modulation of Ca2+/calmodulin-dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: differential regulation of alpha and beta isoforms.
Regulation (regulation) of Ca2+/calmodulin-dependent protein kinase II in hippocampus associated with narcan, hippocampus and morphine
5) Confidence 0.24 Published 1999 Journal Mol. Pharmacol. Section Title Doc Link 10051541 Disease Relevance 0.06 Pain Relevance 0.90
Pathway-specific bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II at spinal nociceptive synapses after acute noxious stimulation.
Regulation (regulation) of calmodulin-dependent protein kinase II in synapses associated with nociception and qutenza
6) Confidence 0.22 Published 2006 Journal J. Neurosci. Section Title Doc Link 16624940 Disease Relevance 0.28 Pain Relevance 0.88
The involvement of both IEGs with the regulation of calcium-calmodulin kinase II (Donai et al., 2003; Takeuchi et al., 2002) may underlie the cortical requirement of this kinase for long-term memory (Frankland et al., 2001).
Regulation (regulation) of calcium-calmodulin kinase II
7) Confidence 0.15 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.09 Pain Relevance 0.03
2,5-hexanedione (HD) treatment alters calmodulin, Ca2+/calmodulin-dependent protein kinase II, and protein kinase C in rats' nerve tissues.
Regulation (alters) of Ca2+/calmodulin-dependent in nerve associated with kinase c
8) Confidence 0.05 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 18582483 Disease Relevance 0.18 Pain Relevance 0.70
The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB.
Regulation (role) of nuclear alphaCaM kinase II
9) Confidence 0.03 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.09 Pain Relevance 0.31

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