INT80345

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2004
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.50
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Camk2b) cytosol (Camk2b) cytoskeleton (Camk2b)
microtubule organizing center (Camk2b) cytoplasm (Camk2b)
Anatomy Link Frequency
dorsal horn 2
neurons 1
hippocampus 1
Camk2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 99.68 Very High Very High Very High
Dorsal horn neuron 1 99.40 Very High Very High Very High
Morphine 10 98.80 Very High Very High Very High
spinal dorsal horn 14 98.28 Very High Very High Very High
qutenza 4 96.44 Very High Very High Very High
long-term potentiation 33 95.72 Very High Very High Very High
c fibre 8 95.64 Very High Very High Very High
opioid receptor 2 95.20 Very High Very High Very High
Sciatic nerve 2 93.60 High High
central sensitization 5 92.24 High High
Disease Link Frequency Relevance Heat
Nociception 3 98.08 Very High Very High Very High
Injury 1 80.28 Quite High
INFLAMMATION 1 79.80 Quite High
Opiate Addiction 1 77.04 Quite High
Anaerobic Bacterial Infections 2 34.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrated that both acute and chronic morphine treatments could effectively modulate the activity and the expression of CaMK II in the hippocampus.
Gene_expression (expression) of CaMK II in hippocampus associated with hippocampus and morphine
1) Confidence 0.77 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10051541 Disease Relevance 0.08 Pain Relevance 1.02
Here we demonstrate an increased expression and phosphorylation of CaMK II in rat spinal dorsal horn neurons after noxious stimulation by intradermal injection of capsaicin.
Gene_expression (expression) of CaMK II in neurons associated with qutenza and dorsal horn neuron
2) Confidence 0.76 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019337 Disease Relevance 0.42 Pain Relevance 0.63
In the present study, we examined the expression of CaMK II and phospho-CaMK II in the lumbar segments (L4-L6) of the rat spinal dorsal horn at 30 min and 3 h after the establishment of LTP induced by tetanic electrical stimulation of the sciatic nerve (40 V, 0.5 ms pulses at 100 Hz for 1 s repeated four times at 10 s intervals) by using Western blot and electrophysiological techniques.
Spec (examined) Gene_expression (expression) of CaMK II in dorsal horn associated with spinal dorsal horn, sciatic nerve and long-term potentiation
3) Confidence 0.59 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.90
In the present study, we examined the expression of CaMK II and phospho-CaMK II in the lumbar segments (L4-L6) of the rat spinal dorsal horn at 30 min and 3 h after the establishment of LTP induced by tetanic electrical stimulation of the sciatic nerve (40 V, 0.5 ms pulses at 100 Hz for 1 s repeated four times at 10 s intervals) by using Western blot and electrophysiological techniques.
Spec (examined) Gene_expression (expression) of CaMK II in dorsal horn associated with spinal dorsal horn, sciatic nerve and long-term potentiation
4) Confidence 0.52 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.90

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