INT80346

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Camk2b) cytosol (Camk2b) cytoskeleton (Camk2b)
microtubule organizing center (Camk2b) cytoplasm (Camk2b)
Anatomy Link Frequency
spinal cord 1
Camk2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 20 99.70 Very High Very High Very High
Spinal cord 2 99.68 Very High Very High Very High
tolerance 2 99.44 Very High Very High Very High
qutenza 4 98.88 Very High Very High Very High
narcan 6 98.60 Very High Very High Very High
Dorsal horn neuron 1 96.32 Very High Very High Very High
opioid receptor 4 95.16 Very High Very High Very High
Hippocampus 6 91.52 High High
withdrawal 2 88.44 High High
central sensitization 5 85.56 High High
Disease Link Frequency Relevance Heat
Nociception 3 96.72 Very High Very High Very High
Opiate Addiction 2 88.80 High High
Injury 1 73.60 Quite High
INFLAMMATION 1 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local administration of a CaMK II inhibitor in the spinal cord significantly inhibits the enhancement of responses of spinal nociceptive neurons and changes in exploratory behavior evoked by capsaicin injection.
Negative_regulation (inhibitor) of CaMK II in spinal cord associated with nociception, qutenza and spinal cord
1) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019337 Disease Relevance 0.41 Pain Relevance 0.67
The effects of both acute and chronic morphine treatments on CaMK II could be completely abolished by the concomitant application of naloxone, indicating that the effects of morphine were achieved through activation of opioid receptors.
Negative_regulation (abolished) of CaMK II associated with narcan, opioid receptor and morphine
2) Confidence 0.42 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10051541 Disease Relevance 0.09 Pain Relevance 1.18
However, chronic morphine treatment, by which rats were observed to develop apparent tolerance to morphine, significantly down-regulated both Ca2+/calmodulin-independent and Ca2+/calmodulin-dependent activities of CaMK II and differentially regulated the expression of alpha and beta isoforms of CaMK II at protein and mRNA levels.
Negative_regulation (down-regulated) of CaMK II associated with tolerance and morphine
3) Confidence 0.42 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10051541 Disease Relevance 0.08 Pain Relevance 0.96

General Comments

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