INT8037

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 39
Total Number 40
Disease Relevance 5.15
Pain Relevance 17.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
brain 3
spinal cords 2
tail 1
Bladder 1
brainstem 1
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 67 100.00 Very High Very High Very High
antagonist 52 100.00 Very High Very High Very High
noradrenaline 44 100.00 Very High Very High Very High
neuralgia 6 100.00 Very High Very High Very High
anesthesia 4 100.00 Very High Very High Very High
medulla 5 99.96 Very High Very High Very High
Eae 11 99.90 Very High Very High Very High
monoamine 8 99.84 Very High Very High Very High
Clonidine 77 99.60 Very High Very High Very High
Glutamate 9 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 8 99.08 Very High Very High Very High
Mydriatic 7 97.94 Very High Very High Very High
Bordatella Infection 1 97.88 Very High Very High Very High
Injury 8 97.76 Very High Very High Very High
Neuropathic Pain 6 97.40 Very High Very High Very High
Heart Rate Under Development 11 97.12 Very High Very High Very High
Fever 1 93.92 High High
Attention Deficit Hyperactivity Disorder 2 92.72 High High
Hypotension 2 92.60 High High
Stress 3 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bladder capacity was decreased with the alpha 2 agonist while the antagonist increased capacity.
Negative_regulation (decreased) of alpha 2 in Bladder associated with antagonist, eae and agonist
1) Confidence 0.42 Published 1993 Journal J. Urol. Section Abstract Doc Link 8093264 Disease Relevance 0.32 Pain Relevance 0.46
We propose that the alpha-2 adrenoceptors in the amygdala/pyriform region contribute to the prophylactic effects of systemically administered clonidine and that the facilitation of kindling observed after systemic administration of alpha-2 antagonists may be due to blockade of alpha-2 adrenoceptors outside of the amygdala/pyriform region.
Negative_regulation (blockade) of alpha-2 in amygdala associated with antagonist, amygdala and clonidine
2) Confidence 0.42 Published 1993 Journal Brain Res. Section Abstract Doc Link 7908598 Disease Relevance 0 Pain Relevance 0.67
It can be concluded that chronic clonidine administration can induce down-regulation of both the alpha 2 presynaptic autoreceptors located on noradrenaline terminals and the alpha 2 presynaptic heteroreceptors located on serotonin terminals.
Negative_regulation (down-regulation) of alpha 2 associated with noradrenaline, serotonin and clonidine
3) Confidence 0.42 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990964 Disease Relevance 0 Pain Relevance 0.66
It can be concluded that chronic clonidine administration can induce down-regulation of both the alpha 2 presynaptic autoreceptors located on noradrenaline terminals and the alpha 2 presynaptic heteroreceptors located on serotonin terminals.
Negative_regulation (down-regulation) of alpha 2 associated with noradrenaline, serotonin and clonidine
4) Confidence 0.42 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990964 Disease Relevance 0 Pain Relevance 0.67
BACKGROUND: alpha 2-Adrenoceptor agonists, known as antihypertensive agents, may be used during general anesthesia for their anesthetic sparing action and to reduce the occurrence of side effects.
Negative_regulation (reduce) of alpha 2 associated with anesthesia and agonist
5) Confidence 0.42 Published 1993 Journal Anesthesiology Section Abstract Doc Link 8238984 Disease Relevance 0 Pain Relevance 0.62
The present study was carried out to clarify whether the imidazolines clonidine, moxonidine and cirazoline as well as the guanidine aganodine inhibit noradrenaline release in the rat and rabbit brain via imidazoline receptors, alpha 2-adrenoceptors and/or histamine H3 receptors.
Spec (whether) Negative_regulation (inhibit) of alpha 2 in brain associated with noradrenaline and clonidine
6) Confidence 0.42 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9116590 Disease Relevance 0 Pain Relevance 0.33
Slices or synaptosomes from the rat or the rabbit brain were incubated with 3H-noradrenaline and exposed to phenoxybenzamine, which irreversibly blocks presynaptic alpha 2-adrenoceptors and, at considerably lower potency, imidazoline receptors.
Negative_regulation (blocks) of alpha 2 in brain associated with noradrenaline and potency
7) Confidence 0.42 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9116590 Disease Relevance 0 Pain Relevance 0.44
Alpha 2-adrenoceptor density was reduced in all the regions studied (cortex, hippocampus, hypothalamus) with, again, no change in their apparent affinity.
Negative_regulation (reduced) of Alpha 2 in hippocampus associated with hippocampus
8) Confidence 0.40 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.25 Pain Relevance 0.22
Chronic clonidine induces functional down-regulation of presynaptic alpha 2-adrenoceptors regulating [3H]noradrenaline and [3H]5-hydroxytryptamine release in the rat brain.
Negative_regulation (down-regulation) of alpha 2 in brain associated with noradrenaline and clonidine
9) Confidence 0.37 Published 1985 Journal Eur. J. Pharmacol. Section Title Doc Link 2990964 Disease Relevance 0 Pain Relevance 0.65
The pharmacological profile of Org 6906, a potential non-sedative antidepressant that combines monoamine uptake inhibition with alpha 2-adrenolytic activity.
Negative_regulation (inhibition) of alpha 2-adrenolytic associated with antidepressant and monoamine
10) Confidence 0.35 Published 1988 Journal Neuropharmacology Section Title Doc Link 2897643 Disease Relevance 0.07 Pain Relevance 0.39
A blockade of alpha-2 receptors significantly decreased basal gastric tone and restored the amplitude of phasic contractions.
Negative_regulation (blockade) of alpha-2
11) Confidence 0.31 Published 1991 Journal Acta Physiol. Scand. Section Abstract Doc Link 1683093 Disease Relevance 0.39 Pain Relevance 0.45
Yohimbine, an alpha-2 blocker, significantly decreased gastric basal tone and reversed the inhibition of phasic contractions induced by clonidine.
Negative_regulation (blocker) of alpha-2 associated with clonidine
12) Confidence 0.31 Published 1991 Journal Acta Physiol. Scand. Section Abstract Doc Link 1683093 Disease Relevance 0.53 Pain Relevance 0.55
Repeated tail pinch leads to desensitization of postsynaptic alpha2-adrenoceptors which modulate the jaw-opening reflex in the rat.
Negative_regulation (desensitization) of alpha2-adrenoceptors in tail
13) Confidence 0.30 Published 1998 Journal Psychopharmacology (Berl.) Section Title Doc Link 9694532 Disease Relevance 0.09 Pain Relevance 0.29
Similar relative potencies were obtained in vivo in pithed rats with regard to blocking peripherally located postjunctional and prejunctional alpha-2 adrenoceptors (L-659,066 = one-seventh and one-fourth of L-657,743, respectively).
Negative_regulation (blocking) of alpha-2
14) Confidence 0.29 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2896239 Disease Relevance 0.08 Pain Relevance 0.47
Alterations in spontaneous and glutamate-evoked activities after blockade of alpha-2 adrenoreceptors were not observed in LC neurons of reserpinized rats.
Negative_regulation (blockade) of alpha-2 in neurons associated with glutamate and locus ceruleus
15) Confidence 0.27 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 8747203 Disease Relevance 0 Pain Relevance 1.11
Therefore, idazoxan is a potent and probably the most selective alpha 2-adrenoceptor blocking agent presently available and is now frequently used for the investigation of peripheral and central alpha 2-adrenoceptors.
Negative_regulation (blocking) of alpha 2
16) Confidence 0.23 Published 1986 Journal J Pharmacol Section Abstract Doc Link 2875218 Disease Relevance 0.08 Pain Relevance 0.24
The results show not only the efficacy of alpha adrenergic antagonists in protecting against reserpine rigidity but more importantly that the blockade of alpha-2 receptors may be the functionally important action.
Negative_regulation (blockade) of alpha-2 associated with antagonist
17) Confidence 0.23 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6124006 Disease Relevance 0.07 Pain Relevance 0.49
Phentolamine and SKF-7265, which block both alpha-1 and alpha-2 receptors, were also effective.
Negative_regulation (block) of alpha-2
18) Confidence 0.23 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6124006 Disease Relevance 0.09 Pain Relevance 0.53
In brainstem, alpha-2- and beta-receptors were reduced by 60 and 74%.
Negative_regulation (reduced) of alpha-2 in brainstem associated with medulla
19) Confidence 0.22 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6123960 Disease Relevance 0 Pain Relevance 0.27
Structure-activity relationship of yohimbine and its related analogs in blocking alpha-1 and alpha-2 adrenoceptors: a comparative study of cardiovascular activities.
Negative_regulation (blocking) of alpha-2
20) Confidence 0.16 Published 1990 Journal Chem. Pharm. Bull. Section Title Doc Link 1976443 Disease Relevance 0 Pain Relevance 0.10

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