INT80385

Context Info Confidence 0.35 First Reported 1999 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.26 Pain Relevance 0.89

cell adhesion (GP9) plasma membrane (GP9)

Anatomy Link Frequency neutrophil 1 GP9 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 2 100.00 potassium channel 4 99.16 sodium channel 2 97.56 tetrodotoxin 4 96.68 Angina 1 85.76 agonist 2 85.44 Pain 1 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 1 87.20 Cv General 3 Under Development 1 85.76 Acute Coronary Syndrome 1 84.24 Bites And Stings 1 5.00 Aggression 1 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The leukocyte population was isolated by a nucleic acid probe (LDS 751) and platelet-neutrophil coaggregates identified as particles binding both anti-CD42a-FITC and anti-CD45-PE.

CD42a Binding (binding) of in neutrophil

1) Confidence 0.35 Published 1999 Journal Thromb. Haemost. Section Abstract Doc Link 10064007 Disease Relevance 0.26 Pain Relevance 0.16

We found Gp-9B in all samples, but Gp-9b cDNA was obtained only from the polygyne sample from North Carolina (Fig. 13).

Gp-9B Binding (found) of

2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582448 Disease Relevance 0 Pain Relevance 0

JZTX-IX shifted the voltage dependence of channel activation to more positive voltages, but binding of toxin to ion channels was not reversible by extreme depolarization.

JZTX-IX Binding (binding) of associated with addiction

3) Confidence 0.16 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19409400 Disease Relevance 0 Pain Relevance 0.37

JZTX-IX was found to interact with multiple types of ion channels including voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel.

JZTX-IX Binding (interact) of associated with tetrodotoxin and sodium channel

4) Confidence 0.16 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19409400 Disease Relevance 0 Pain Relevance 0.36

General Comments

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