INT80405

Context Info Confidence 0.06 First Reported 1999 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 0.52 Pain Relevance 4.03

cell differentiation (Gnptab) Golgi apparatus (Gnptab) nucleus (Gnptab) transcription factor binding (Gnptab)

Anatomy Link Frequency tail 1 Gnptab (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 276 99.40 Kinase C 82 98.40 Hippocampus 24 97.88 tolerance 99 97.76 Morphine 245 97.36 antinociception 15 95.04 Intracerebroventricular 9 92.40 GABAergic 24 89.60 addiction 3 87.48 Opioid 72 86.00

Disease Link Frequency Relevance Heat Ataxia 1 96.24 Stress 9 85.52 Stomach Cancer 1 78.40 Hereditary Sensory And Autonomic Neuropathies 1 74.24 Neuropathic Pain 2 66.48 Urological Neuroanatomy 48 62.08 Dystonia 1 59.04 Clinical Trials And Case Reports 1 50.00 Sprains And Strains 51 42.52 Pain 8 18.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of Galpha subunits was also reduced by blocking their mRNA with antisense oligodeoxynucleotides (ODN).

Gene_expression (expression) of subunits

1) Confidence 0.06 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10064886 Disease Relevance 0 Pain Relevance 0.08

subunits was stably transferred to RGS proteins in a time-dependent manner.

Gene_expression (transferred) of subunits

2) Confidence 0.02 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.58

subunits are progressively transferred under the control of certain RGS proteins by a PKC-dependent mechanism [46], [48].

Gene_expression (transferred) of subunits associated with kinase c

3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 1.34

Non-receptor tyrosine kinases phosphorylate specific tyrosine residues in the cytosolic tail of NR2 and, potentially, NR3 subunits [4], producing an increase in the permeation of Ca2+ ions towards the cytosolic side of the postsynapse.

Gene_expression (producing) of subunits in tail

4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.39

subunits, however there was a significant higher expression of the ?

Gene_expression (expression) of subunits

5) Confidence 0.01 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0 Pain Relevance 0.56

Within the Cct subfamily, it is surprising that subunits of a heteromeric octamer are not uniformly expressed at identical levels (Figure 8).

Neg (not) Gene_expression (expressed) of subunits

6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.38 Pain Relevance 0.07

In summary, it was shown that there is a marked and time-dependent increase in the mRNA expression of both sGC subunits in differentiated cells relative to undifferentiated hESCs.

Gene_expression (expression) of subunits

7) Confidence 0.01 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.08 Pain Relevance 0

General Comments

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