INT80405

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Context Info
Confidence 0.06
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.52
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gnptab) Golgi apparatus (Gnptab) nucleus (Gnptab)
transcription factor binding (Gnptab)
Anatomy Link Frequency
tail 1
Gnptab (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 276 99.40 Very High Very High Very High
Kinase C 82 98.40 Very High Very High Very High
Hippocampus 24 97.88 Very High Very High Very High
tolerance 99 97.76 Very High Very High Very High
Morphine 245 97.36 Very High Very High Very High
antinociception 15 95.04 Very High Very High Very High
Intracerebroventricular 9 92.40 High High
GABAergic 24 89.60 High High
addiction 3 87.48 High High
Opioid 72 86.00 High High
Disease Link Frequency Relevance Heat
Ataxia 1 96.24 Very High Very High Very High
Stress 9 85.52 High High
Stomach Cancer 1 78.40 Quite High
Hereditary Sensory And Autonomic Neuropathies 1 74.24 Quite High
Neuropathic Pain 2 66.48 Quite High
Urological Neuroanatomy 48 62.08 Quite High
Dystonia 1 59.04 Quite High
Clinical Trials And Case Reports 1 50.00 Quite Low
Sprains And Strains 51 42.52 Quite Low
Pain 8 18.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of Galpha subunits was also reduced by blocking their mRNA with antisense oligodeoxynucleotides (ODN).
Gene_expression (expression) of subunits
1) Confidence 0.06 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10064886 Disease Relevance 0 Pain Relevance 0.08
subunits was stably transferred to RGS proteins in a time-dependent manner.
Gene_expression (transferred) of subunits
2) Confidence 0.02 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.58
subunits are progressively transferred under the control of certain RGS proteins by a PKC-dependent mechanism [46], [48].
Gene_expression (transferred) of subunits associated with kinase c
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 1.34
Non-receptor tyrosine kinases phosphorylate specific tyrosine residues in the cytosolic tail of NR2 and, potentially, NR3 subunits [4], producing an increase in the permeation of Ca2+ ions towards the cytosolic side of the postsynapse.
Gene_expression (producing) of subunits in tail
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.39
subunits, however there was a significant higher expression of the ?
Gene_expression (expression) of subunits
5) Confidence 0.01 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0 Pain Relevance 0.56
Within the Cct subfamily, it is surprising that subunits of a heteromeric octamer are not uniformly expressed at identical levels (Figure 8).
Neg (not) Gene_expression (expressed) of subunits
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.38 Pain Relevance 0.07
In summary, it was shown that there is a marked and time-dependent increase in the mRNA expression of both sGC subunits in differentiated cells relative to undifferentiated hESCs.
Gene_expression (expression) of subunits
7) Confidence 0.01 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.08 Pain Relevance 0

General Comments

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