INT80421

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 15.32
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (IFI27) molecular_function (IFI27)
Anatomy Link Frequency
cleavage 2
spinal 1
osteoblasts 1
bone marrow 1
smooth muscle cell 1
IFI27 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 75 100.00 Very High Very High Very High
agonist 36 98.44 Very High Very High Very High
Inflammation 155 97.56 Very High Very High Very High
COX-2 inhibitor 57 93.84 High High
cytokine 107 92.24 High High
aspirin 14 88.80 High High
antagonist 41 86.64 High High
palliative 9 83.56 Quite High
dexamethasone 5 74.60 Quite High
peptic ulcer disease 2 66.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 186 99.98 Very High Very High Very High
Retinoblastoma 8 99.62 Very High Very High Very High
Cancer 512 99.28 Very High Very High Very High
Congenital Anomalies 8 99.18 Very High Very High Very High
Stress 11 98.74 Very High Very High Very High
Testicular Cancer 147 97.62 Very High Very High Very High
Lung Cancer 106 96.80 Very High Very High Very High
Death 53 96.48 Very High Very High Very High
Apoptosis 237 95.96 Very High Very High Very High
Necrosis 11 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrated previously that nonsteroidal anti-inflammatory drugs (NSAIDs) increased p27(Kip1) by inhibiting protein degradation to suppress the proliferation of human lung cancer cells.
Positive_regulation (increased) of p27 in lung associated with lung cancer, inflammation and cinod
1) Confidence 0.65 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.27 Pain Relevance 0.56
Western blot analysis showed a decrease in cyclin D1 and an increase in p21 and p27, indicating that the mechanism of this growth inhibition is cell cycle arrest.
Positive_regulation (increase) of p27
2) Confidence 0.51 Published 2007 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17874277 Disease Relevance 1.14 Pain Relevance 0.08
RESULTS: Significantly higher levels of anti-pso p27 antibodies were found in patients with myelographic signs of disc herniation than in with patients with no signs of herniation, patients with spinal stenosis, and control subjects.
Positive_regulation (levels) of p27 in spinal
3) Confidence 0.50 Published 1999 Journal Spine Section Body Doc Link 10065522 Disease Relevance 0.23 Pain Relevance 0
On the contrary, we found that NSAIDs inhibited proteasome activity to increase p27(Kip1) protein levels.
Positive_regulation (increase) of p27 associated with cinod
4) Confidence 0.47 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.24 Pain Relevance 0.68
Mechanisms underlying nonsteroidal anti-inflammatory drug-induced p27(Kip1) expression.
Positive_regulation (drug-induced) of p27 associated with inflammation and cinod
5) Confidence 0.47 Published 2002 Journal Mol. Pharmacol. Section Title Doc Link 12435820 Disease Relevance 0.29 Pain Relevance 0.73
on both the expression and activity of cyclin-dependent kinase inhibitors [CDKI] such as p21 and p27.
Positive_regulation (activity) of p27
6) Confidence 0.44 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.57 Pain Relevance 0
The involvement of PI3K/Akt inhibition and p27 upregulation, as well as hypophosphorylation of Rac1 at ser71, were demonstrated.
Positive_regulation (upregulation) of p27
7) Confidence 0.44 Published 2010 Journal Mol. Carcinog. Section Abstract Doc Link 19908241 Disease Relevance 0.95 Pain Relevance 0.45
On the other hand, FOXO silencing significantly attenuated the drug-induced up-regulation of p27(Kip1) and suppression of proliferation in hOBs.
Positive_regulation (up-regulation) of p27
8) Confidence 0.40 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19883628 Disease Relevance 0.44 Pain Relevance 0.47
Previous studies indicated that anti-inflammatory drugs up-regulated p27(Kip1), and this effect might play an important role in anti-inflammatory drug-induced cell cycle arrest of human osteoblasts (hOBs).
Positive_regulation (up-regulated) of p27 in osteoblasts associated with inflammation and cinod
9) Confidence 0.40 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19883628 Disease Relevance 0.35 Pain Relevance 0.29
In normal cells, p27 is sequestered and its activity gradually decreases as cells reach S phase, p27 preferentially binds cyclin D-cdk4, but lower levels of cdk4 (in TGF-?
Positive_regulation (reach) of p27
10) Confidence 0.19 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.14 Pain Relevance 0
In particular, TGCT has been shown to be associated with a characteristic series of abnormalities in the retinoblastoma pathway including upregulation of cyclin D2 and p27 and downregulation of RB1 and the cyclin-dependent kinase inhibitors of p16, p18, p19 and p21 [13].
Positive_regulation (upregulation) of p27 associated with congenital anomalies, testicular cancer and retinoblastoma
11) Confidence 0.18 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 1.42 Pain Relevance 0
Induction of the stress-related kinase JNK (c-Jun amino terminal kinase) and p38, and upregulation of p21 and p27 are also observed after co-treatment of cells with HDACi and MG-132.
Positive_regulation (upregulation) of p27 associated with stress
12) Confidence 0.18 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.33 Pain Relevance 0.03
In normal human fibroblasts, G1-phase cell accumulation was concomitant with the reduction in Rb protein phosphorylation; that, however, appeared to be dependent on p21(WAF1/CIP1) rather than on p27(KIP1) protein.
Positive_regulation (dependent) of p27 in fibroblasts
13) Confidence 0.17 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.23 Pain Relevance 0
The cell cycle inhibition occurred concomitantly with an increase in p27(KIP1) protein levels, a reduction in Rb protein phosphorylation on serine residues 807-811, and a significant decrease in cyclin E-associated cdk2 activity.
Positive_regulation (increase) of p27
14) Confidence 0.17 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.57 Pain Relevance 0.07
This complex then increases cellular cyclin dependent kinase inhibitor (CDKI) p27 and inhibits the action of retinoblastoma protein (pRb), which regulates vascular smooth muscle cell proliferation (11, 13).
Positive_regulation (increases) of p27 in smooth muscle cell associated with retinoblastoma
15) Confidence 0.17 Published 2007 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2323487 Disease Relevance 0.66 Pain Relevance 0.04
Moreover, the inhibition of cell proliferation was correlated to a downregulation of cyclin D1, cyclin E, and pRb and the upregulation of p16 and p27 [89].
Positive_regulation (upregulation) of p27
16) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.98 Pain Relevance 0.10
The nuclei were diffusely positive for Chk2 and p27, which is considered to be the normal staining pattern for these markers.
Positive_regulation (positive) of p27
17) Confidence 0.12 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 0.62 Pain Relevance 0
On the contrary, no variation in levels of p21 and p27 was observed in Ist-Mes-1 and MPP89.
Neg (no) Positive_regulation (variation) of p27
18) Confidence 0.10 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.15 Pain Relevance 0.09
Indeed, in this cell line, treatment with single agent or rofecoxib and gefitinib as combination induced a significant increase of p21 and p27.
Positive_regulation (increase) of p27
19) Confidence 0.10 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.09 Pain Relevance 0
Other important mechanisms of action comprise the internalization and degradation of Her2 receptor protein (Cuello et al 2001), decrease of cyclin dependent kinase 2 (CDK2) activity via p27 induction (Lane et al 2001), blockade of downstream Her2 signaling pathways (Yakes et al 2002), and inhibition of DNA repair (Nahta et al 2006).
Positive_regulation (induction) of p27
20) Confidence 0.09 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721347 Disease Relevance 0.12 Pain Relevance 0

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