INT8043

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Context Info
Confidence 0.31
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.11
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ntsr2) signal transducer activity (Ntsr2)
Anatomy Link Frequency
basal ganglia 1
Ntsr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 7 99.50 Very High Very High Very High
Analgesic 80 99.34 Very High Very High Very High
agonist 7 98.56 Very High Very High Very High
analgesia 43 95.28 Very High Very High Very High
Antinociceptive 42 95.24 Very High Very High Very High
Neuropeptide 17 88.04 High High
Intracerebroventricular 3 84.40 Quite High
tail-flick 18 83.60 Quite High
Dopamine 1 75.00 Quite High
antagonist 15 74.16 Quite High
Disease Link Frequency Relevance Heat
Pain 28 56.24 Quite High
Nociception 10 35.28 Quite Low
Syndrome 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structure-activity studies revealed a close correlation between the analgesic potency of NT analogs and their affinity for the NTR2 and disclosed potent and selective agonists of this receptor.
NTR2 Binding (affinity) of associated with analgesic, agonist and potency
1) Confidence 0.31 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9870978 Disease Relevance 0 Pain Relevance 0.79
Structure–activity studies reveal a close correlation between the analgesic potency of NT analogs and their affinity for the NT receptor 2 (NTR2) and discloses potent and selective agonists of this receptor, which confirms the fact that NTR2 mediates NT-induced analgesia.
NT receptor 2 Binding (affinity) of associated with analgesic, agonist, analgesia and potency
2) Confidence 0.25 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.06 Pain Relevance 1.12
Structure–activity studies reveal a close correlation between the analgesic potency of NT analogs and their affinity for the NT receptor 2 (NTR2) and discloses potent and selective agonists of this receptor, which confirms the fact that NTR2 mediates NT-induced analgesia.
NTR2 Binding (affinity) of associated with analgesic, agonist, analgesia and potency
3) Confidence 0.25 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.06 Pain Relevance 1.13
Evidence has been presented that behavioral actions of NT, inducing its neuroleptic-like action, can be explained on the basis of NT-D2 intramembrane receptor-receptor interactions in the basal ganglia, unrelated to the coexistence phenomenon, leading to reduced affinity and transduction of the D2 agonist binding site.
NT-D2 Binding (interactions) of in basal ganglia associated with agonist
4) Confidence 0.00 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1361113 Disease Relevance 0 Pain Relevance 0.09

General Comments

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