INT80435

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Context Info
Confidence 0.34
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
neurons 2
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 102 100.00 Very High Very High Very High
Glutamate 4 99.68 Very High Very High Very High
central pain 20 98.86 Very High Very High Very High
analgesia 7 97.04 Very High Very High Very High
Pain 9 90.64 High High
Potency 2 77.44 Quite High
Analgesic 4 76.36 Quite High
Neurolysis 1 74.24 Quite High
Hyperalgesia 1 62.88 Quite High
allodynia 1 62.20 Quite High
Disease Link Frequency Relevance Heat
Pain 29 98.86 Very High Very High Very High
Generalized Anxiety Disorder 1 86.64 High High
Hyperalgesia 1 62.88 Quite High
Neuropathic Pain 1 62.20 Quite High
Anxiety Disorder 1 34.84 Quite Low
Injury 1 25.04 Quite Low
Stroke 1 23.96 Low Low
Intractable Pain 1 10.96 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since destruction of the first or second order excitatory neurons produces analgesia, then it seems plausible that destruction of the third order neurons produces central pain because these neurons are net inhibitory and there is a deficiency of GABA or increase in the glutamate: GABA ratio.
Negative_regulation (deficiency) of Positive_regulation (increase) of GABA in neurons associated with pain, central pain, glutamate, gaba and analgesia
1) Confidence 0.34 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.69 Pain Relevance 2.04
The 3beta-pregnane isomers epipregnanolone and isopregnanolone both inhibited the ability of allopregnanolone and alphaxalone to potentiate GABA(A) receptor function.
Negative_regulation (inhibited) of Positive_regulation (potentiate) of GABA associated with gaba
2) Confidence 0.09 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10066142 Disease Relevance 0 Pain Relevance 0.40

General Comments

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