INT80447

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.12
Pain Relevance 6.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB2) cytoplasmic membrane-bounded vesicle (ARRB2) plasma membrane (ARRB2)
nucleus (ARRB2) cytoplasm (ARRB2)
Anatomy Link Frequency
brains 3
plasma 1
ARRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 20 100.00 Very High Very High Very High
Morphine 18 99.84 Very High Very High Very High
addiction 6 99.06 Very High Very High Very High
opiate 33 99.00 Very High Very High Very High
methadone 6 97.72 Very High Very High Very High
agonist 2 92.60 High High
tolerance 6 92.48 High High
substance P 3 89.68 High High
Kinase C 2 86.00 High High
Opioid 10 85.56 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 6 99.06 Very High Very High Very High
Death 16 98.48 Very High Very High Very High
Overdose 6 98.08 Very High Very High Very High
Breast Cancer 6 92.04 High High
Apoptosis 4 85.12 High High
Pain 5 83.28 Quite High
Cancer 4 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that opiate addiction in humans (tolerant state) is associated with down-regulation of brain micro-opioid receptors and regulatory GRK 2/6 and beta-arrestin-2 proteins.
Negative_regulation (down-regulation) of beta-arrestin-2 in brain associated with addiction, opioid receptor and opiate
1) Confidence 0.39 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14969742 Disease Relevance 0.30 Pain Relevance 1.19
Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts.
Negative_regulation (Decreased) of beta-arrestin-2 in brains associated with opiate and opioid receptor
2) Confidence 0.39 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 14969742 Disease Relevance 0.21 Pain Relevance 0.94
In the same brains, significant decreases in the immunodensities of GRK 2 (19%, n=24, P<0.05), GRK 6 (25%, n=24, P<0.002) and beta-arrestin-2 (22%, n=24, P< 0.0005) were also quantitated.
Negative_regulation (decreases) of beta-arrestin-2 in brains
3) Confidence 0.39 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14969742 Disease Relevance 0.34 Pain Relevance 1.21
However, blockade of morphine-induced cell death by beta-arrestin2 seems to be dependent on the inhibition of caspase-8, as inhibition of beta-arrestin2 and morphine treatment significantly enhanced the levels of cleaved caspase-8.
Negative_regulation (inhibition) of beta-arrestin2 associated with death and morphine
4) Confidence 0.30 Published 2009 Journal Neoplasma Section Abstract Doc Link 19239323 Disease Relevance 1.11 Pain Relevance 1.31
Suppression of endogenous beta-arrestin2 by specific RNA interfering (RNAi) and morphine treatment significantly attenuates the levels of phosphorylated Akt compared with inhibition of beta-arrestin2 or morphine treatment alone.
Negative_regulation (inhibition) of beta-arrestin2 associated with morphine
5) Confidence 0.30 Published 2009 Journal Neoplasma Section Abstract Doc Link 19239323 Disease Relevance 1.10 Pain Relevance 1.31
This desensitization process coincides with a redistribution of GRK2 from the cytosol to the plasma membrane, followed by a robust redistribution of beta-arrestin 2 and a profound change in cell morphology that occurs after 1 min of SPR stimulation.
Negative_regulation (redistribution) of beta-arrestin 2 in plasma
6) Confidence 0.27 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10066824 Disease Relevance 0.06 Pain Relevance 0.34

General Comments

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