INT80452

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.77
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pthlh) Golgi apparatus (Pthlh) nucleolus (Pthlh)
nucleus (Pthlh) intracellular (Pthlh) cellular_component (Pthlh)
Anatomy Link Frequency
parathyroid 6
neuronal 2
Pthlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 2 98.76 Very High Very High Very High
opioid receptor 3 94.88 High High
agonist 2 90.20 High High
Thalamus 1 83.44 Quite High
Enkephalin 1 77.08 Quite High
Pain 2 64.16 Quite High
addiction 2 57.36 Quite High
Central nervous system 3 41.88 Quite Low
Disease Link Frequency Relevance Heat
Cancer 13 100.00 Very High Very High Very High
Metastasis 7 99.92 Very High Very High Very High
Hypercalcemia 15 99.90 Very High Very High Very High
Congenital Anomalies 1 99.36 Very High Very High Very High
Malignant Neoplastic Disease 2 98.98 Very High Very High Very High
Low Back Pain 2 98.76 Very High Very High Very High
Osteoporosis 6 98.72 Very High Very High Very High
Breast Cancer 1 94.80 High High
Digeorge Syndrome 1 89.68 High High
Pain 2 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The back pain and biochemical abnormalities presented as hypercalcemia and elevated plasma levels of the parathyroid hormone-related protein (PTH-rP) that returned to normal indices with increasing BMD after weaning.
Positive_regulation (elevated) of Gene_expression (levels) of PTH-rP in parathyroid associated with congenital anomalies, hypercalcemia and backache
1) Confidence 0.40 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 10067016 Disease Relevance 0.47 Pain Relevance 0.19
Malignancy-associated hypercalcemia (MAH) is caused by tumor over-production of parathyroid hormone-related protein (PTHrP), or by locally enhanced bone resorption in metastatic lesions of solid cancers.
Positive_regulation (over-production) of Gene_expression (production) of parathyroid hormone-related protein in parathyroid associated with malignant neoplastic disease, cancer and hypercalcemia
2) Confidence 0.27 Published 2006 Journal Clin Calcium Section Abstract Doc Link 16582519 Disease Relevance 1.18 Pain Relevance 0.06
The neuronal changes in SA animals were correlated with elevated adrenocorticotrophic hormone (ACTH) (64% and 104%) and glucocorticoid production (198% and 79%) compared with YH and YS groups, respectively.
Positive_regulation (elevated) of Gene_expression (production) of adrenocorticotrophic hormone in neuronal
3) Confidence 0.03 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19467321 Disease Relevance 0.15 Pain Relevance 0.32
Bone-derived TGFbeta plays an integral role in promoting the development and progression of osteolytic bone metastases by inducing tumor production of parathyroid hormone-related protein (PTHrP), a known stimulator of osteoclastic bone resorption.
Positive_regulation (inducing) of Gene_expression (production) of hormone-related protein in parathyroid associated with cancer, hypercalcemia, osteoporosis and metastasis
4) Confidence 0.01 Published 2000 Journal Crit. Rev. Eukaryot. Gene Expr. Section Abstract Doc Link 11186331 Disease Relevance 1.98 Pain Relevance 0.05

General Comments

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