INT80463

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Context Info
Confidence 0.07
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.49
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gucy1a2) cytoplasm (Gucy1a2)
Anatomy Link Frequency
spinal 1
gastric smooth muscle 1
DRG 1
Gucy1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 7 98.64 Very High Very High Very High
Catecholamine 1 98.20 Very High Very High Very High
gABA 16 98.14 Very High Very High Very High
antagonist 4 97.98 Very High Very High Very High
analgesia 1 97.88 Very High Very High Very High
agonist 4 97.68 Very High Very High Very High
GABAergic 2 96.32 Very High Very High Very High
Pain 3 94.20 High High
qutenza 3 87.84 High High
noradrenaline 4 86.32 High High
Disease Link Frequency Relevance Heat
Pain 1 94.20 High High
Injury 4 84.80 Quite High
Neuroma 3 80.32 Quite High
Nervous System Injury 6 75.00 Quite High
Neuropathic Pain 4 25.00 Low Low
Syndrome 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Released catecholamine from splanchnic efferents by CCK8 can induce both excitatory and inhibitory reflexes via alpha2 and beta adrenergic receptors located on gastric smooth muscle cells, respectively.
Localization (located) of alpha2 in gastric smooth muscle associated with catecholamine
1) Confidence 0.07 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189113 Disease Relevance 0 Pain Relevance 0.41
Based on neuroanatomical evidence for alpha2A and alpha2C subtypes of alpha2 adrenergic receptors within this region, we hypothesize that noradrenergic alpha2-receptors can influence transmitter release in the SNr.
Localization (release) of alpha2
2) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16356632 Disease Relevance 0 Pain Relevance 0.60
The enhancing effect of both the alpha2 adrenoceptor agonist and antagonist on GABA release, while appearing paradoxical, can be rationalised by actions at distinct subsets of alpha2 adrenoceptors, using a simple model where alpha2A adrenoceptors are localized on the terminals of noradrenergic afferents impinging upon alpha2C adrenoceptor-containing GABAergic striato-nigral neurones.
Localization (localized) of alpha2 associated with gaba, gabaergic, antagonist and agonist
3) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16356632 Disease Relevance 0 Pain Relevance 0.85
Finally, at later times NPY-mediated modulation of NE release from invading sympathetic axon terminals within the DRG may affect the extent of alpha2 rece
Localization (rece) of alpha2 in DRG
4) Confidence 0.05 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.49 Pain Relevance 0.23
Norepinephrine release from spinal synaptosomes: auto-alpha2 -adrenergic receptor modulation.
Localization (release) of auto-alpha2 in spinal
5) Confidence 0.03 Published 2000 Journal Anesthesiology Section Title Doc Link 10861160 Disease Relevance 0 Pain Relevance 0.42

General Comments

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