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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.62
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Spr) oxidoreductase activity (Spr) nucleolus (Spr)
nucleus (Spr) cellular_component (Spr) cytoplasm (Spr)
Anatomy Link Frequency
neurons 1
Spr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 21 98.78 Very High Very High Very High
Hyperalgesia 2 96.00 Very High Very High Very High
allodynia 2 95.08 Very High Very High Very High
Pain 3 93.04 High High
Inflammation 5 91.96 High High
Neuropathic pain 1 86.40 High High
Eae 1 85.36 High High
intrathecal 2 81.88 Quite High
Lasting pain 3 77.52 Quite High
substance P 5 76.16 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 96.00 Very High Very High Very High
Nociception 3 95.52 Very High Very High Very High
Neuropathic Pain 3 95.08 Very High Very High Very High
Pain 4 93.04 High High
INFLAMMATION 3 91.96 High High
Injury 1 85.36 High High
Increased Venous Pressure Under Development 14 80.56 Quite High
Diphtheria 2 75.00 Quite High
Nicotine Addiction 1 60.80 Quite High
Stress 4 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemistry revealed a toxin-induced reduction in lamina I, of SPR and of NMDA NR1 subunit receptor expressing neurons, and of c-Fos, an inducible molecular marker of persistent nociceptive activity.
Negative_regulation (reduction) of SPR in neurons associated with nociception
1) Confidence 0.30 Published 1999 Journal Pain Section Abstract Doc Link 10068170 Disease Relevance 1.19 Pain Relevance 1.16
An alternative pathway for BH4 synthesis, the “salvage pathway,” involves the formation of sepiapterin and its subsequent reduction in dihydrobiopterin (BH2), which is further reduced by dihydrofolate reductase (DHFR) to form BH4.
Negative_regulation (reduction) of sepiapterin associated with tetrahydrobiopterin
2) Confidence 0.01 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.43 Pain Relevance 0.45

General Comments

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