INT8047

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 20
Total Number 24
Disease Relevance 7.96
Pain Relevance 10.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
neurons 4
visceral 1
ileum 1
sensory neurons 1
medulla 1
Nts (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 59 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
Cholecystokinin 31 99.98 Very High Very High Very High
Glutamate 7 99.92 Very High Very High Very High
analgesia 13 99.82 Very High Very High Very High
nociceptor 1 99.78 Very High Very High Very High
Opioid 19 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 9 100.00 Very High Very High Very High
Stress 37 99.80 Very High Very High Very High
Ganglion Cysts 8 99.72 Very High Very High Very High
Targeted Disruption 35 99.48 Very High Very High Very High
Porphyria 8 99.14 Very High Very High Very High
Body Weight 10 98.96 Very High Very High Very High
Sprains And Strains 13 98.72 Very High Very High Very High
Variegate Porphyria 2 96.88 Very High Very High Very High
Aids-related Complex 22 96.48 Very High Very High Very High
Porphyria Cutanea Tarda 2 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lesioning the nigrostriatal pathway increased enkephalin (ENK) and neurotensin (NT) mRNA levels in both mouse strains.
Positive_regulation (increased) of neurotensin associated with enkephalin and sprains and strains
1) Confidence 0.67 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930409 Disease Relevance 0.42 Pain Relevance 0.43
Since central NT produces naloxone-insensitive analgesic effects by acting on spinal and supraspinal NTS2 receptors, we hypothesized that NT might mediate non-opioid SIA through NTS2 activation.
Spec (might) Positive_regulation (activation) of NTS2 in spinal associated with analgesic, narcan, opioid and analgesia
2) Confidence 0.64 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 1.05 Pain Relevance 1.58
Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and rats.
Positive_regulation (required) of neurotensin in visceral associated with stress, nociception, antinociception and nociceptor
3) Confidence 0.49 Published 2004 Journal Neuroscience Section Title Doc Link 15207335 Disease Relevance 1.05 Pain Relevance 0.71
Intraperitoneal administration of cholecystokinin (CCK) induced c-fos gene expression in NTS POMC-EGFP neurons, suggesting that they are activated by afferents stimulated by the satiety hormone.
Positive_regulation (induced) of NTS POMC-EGFP in neurons associated with cholecystokinin
4) Confidence 0.48 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814788 Disease Relevance 0.35 Pain Relevance 0.42
These findings identify a potential satiety pathway in which visceral afferents directly activate NTS POMC-EGFP neurons with excitatory inputs that are appropriately modulated by appetite regulators.
Positive_regulation (activate) of NTS POMC-EGFP in neurons
5) Confidence 0.45 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814788 Disease Relevance 0.12 Pain Relevance 0.74
Electrical activation of the solitary tract (ST) evoked EPSCs in NTS POMC-EGFP neurons.
Positive_regulation (activation) of NTS POMC-EGFP in neurons
6) Confidence 0.45 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814788 Disease Relevance 0.34 Pain Relevance 0.71
These infusates increased plasma NT concentrations to steady state values of about .1, .2, 1, 2, and 10 times the postprandial concentrations of NT in hepatic portal blood, respectively.
Positive_regulation (increased) of NT in blood
7) Confidence 0.43 Published 1993 Journal Poult. Sci. Section Abstract Doc Link 8378227 Disease Relevance 0 Pain Relevance 0
This study shows that, during the 24 h after 40-Hz 20-min stimulation of the preganglionic input to the SG, the rate of NT accumulation proximal to a ligature on the stimulated input is three times that observed in the control.
Positive_regulation (accumulation) of NT in proximal associated with ganglion cysts
8) Confidence 0.40 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004440 Disease Relevance 0.35 Pain Relevance 0.11
When the centripetal propagation of action potentials from the stimulus site on the preganglionic axons is prevented by a tetrodotoxin block applied locally during the stimulation period, the poststimulus increase in NT accumulation rate and the replenishment of the store are both prevented.
Positive_regulation (increase) of NT associated with tetrodotoxin and action potential
9) Confidence 0.40 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004440 Disease Relevance 0.29 Pain Relevance 0.19
Lastly, compared with wt mice, induction of NTS more severely reduced urine osmolality and body mass in EP1-/- mice.
Positive_regulation (induction) of NTS in urine
10) Confidence 0.38 Published 2006 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17111032 Disease Relevance 0.31 Pain Relevance 0.10
These results indicate that neurotensin stimulates the release of glutamate by activating a hypothesized unidentified neurotensin receptor, resulting in the dephosphorylation of DARPP-32 at Thr75 by activating NMDA and AMPA receptors expressed at medium spiny neurons.
Spec (hypothesized) Positive_regulation (activating) of neurotensin in neurons associated with glutamate
11) Confidence 0.37 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.40
The first area concerns the functional activation of the high-affinity NT receptor, NTR-1, including the delineation of the NT binding pocket and receptor domains involved in functional coupling to intracellular signaling pathways.
Positive_regulation (activation) of NT
12) Confidence 0.35 Published 2005 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 16003489 Disease Relevance 0.06 Pain Relevance 0.19
The possible participation of CGRP and/or SP in the chronotropic effect of NT applied on the epicardium, and their putative role as neurotransmitter of cardiac, capsaicin-sensitive, sensory neurons are discussed.
Spec (possible) Positive_regulation (participation) of NT in sensory neurons associated with neurotransmitter, qutenza, substance p and calcitonin gene-related peptide
13) Confidence 0.28 Published 1986 Journal Peptides Section Abstract Doc Link 2436196 Disease Relevance 0.44 Pain Relevance 1.04
In the selective perfusion studies, perfusion of oleic acid into the jejunum of the chronic dog caused NT release, whereas perfusion of the ileum in which NT cells were most abundant was ineffective.
Positive_regulation (caused) of NT in ileum
14) Confidence 0.27 Published 1989 Journal Nippon Geka Hokan Section Abstract Doc Link 2642265 Disease Relevance 0 Pain Relevance 0.06
Furthermore, digested fat, like oleate or digestive juices in the lower small intestine, is not a direct stimulant of NT release.
Neg (not) Positive_regulation (stimulant) of NT in small intestine
15) Confidence 0.27 Published 1989 Journal Nippon Geka Hokan Section Abstract Doc Link 2642265 Disease Relevance 0 Pain Relevance 0.09
The number of c-Fos–positive cells was not increased in response to intragastric glucose in the NTS of GLP-1 Rc knockout mice when compared with wild-type controls.
Neg (not) Positive_regulation (increased) of NTS associated with targeted disruption
16) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.48 Pain Relevance 0.04
In the NTS, the number of c-Fos–positive cells significantly increased by ?
Positive_regulation (increased) of NTS
17) Confidence 0.23 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.27 Pain Relevance 0
The first area concerns the functional activation of the high-affinity NT receptor, NTR-1, including the delineation of the NT binding pocket and receptor domains involved in functional coupling to intracellular signaling pathways.
Positive_regulation (activation) of NT
18) Confidence 0.20 Published 2005 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 16003489 Disease Relevance 0.07 Pain Relevance 0.25
The unconditioned response of NT-LI to electric footshock was observed only at an intensity of 500 microA and only in the lateral subdivision of the VTA.
Positive_regulation (response) of NT in lateral
19) Confidence 0.17 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1361117 Disease Relevance 0.29 Pain Relevance 0.18
During acute attacks of porphyria, polypeptides were found to be constantly increased: vasoactive intestinal polypeptide (VIP); neurotensin (NT); substance P; pancreatic polypeptide; gastrin-releasing peptide; gastrin and motilin.
Positive_regulation (increased) of NT associated with porphyria and substance p
20) Confidence 0.14 Published 1997 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 9074785 Disease Relevance 0.76 Pain Relevance 0.19

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