INT80470

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 10.22
Pain Relevance 27.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
hippocampus 6
neurons 4
visceral 2
retinas 2
striatum 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 214 100.00 Very High Very High Very High
Morphine 155 100.00 Very High Very High Very High
Ventral tegmentum 104 100.00 Very High Very High Very High
antagonist 103 100.00 Very High Very High Very High
Dopamine 74 100.00 Very High Very High Very High
Glutamate receptor 44 100.00 Very High Very High Very High
Hippocampus 33 100.00 Very High Very High Very High
Nucleus accumbens 24 100.00 Very High Very High Very High
ganglionectomy 22 100.00 Very High Very High Very High
allodynia 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 14 100.00 Very High Very High Very High
Dyspepsia 15 99.98 Very High Very High Very High
Urological Neuroanatomy 12 99.84 Very High Very High Very High
INFLAMMATION 48 99.70 Very High Very High Very High
Diabetes Mellitus 92 99.54 Very High Very High Very High
Nociception 35 97.88 Very High Very High Very High
Middle Cerebral Artery Infarction 3 96.68 Very High Very High Very High
Depression 112 96.32 Very High Very High Very High
Hyperalgesia 13 96.00 Very High Very High Very High
Cognitive Disorder 29 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the development of morphine tolerance partly prevented by Group I mGluRs antagonists may due to its inhibitory effect on the expression of NR1 subunit.
Negative_regulation (effect) of Gene_expression (expression) of NR1 subunit associated with antagonist, tolerance and morphine
1) Confidence 0.59 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.58
The antinociception effect and the inhibition of NR1 expression persisted for about 7 days after administration of NR1 siRNA.
Negative_regulation (inhibition) of Gene_expression (expression) of NR1
2) Confidence 0.59 Published 2010 Journal Anesthesiology Section Body Doc Link 20463582 Disease Relevance 0.15 Pain Relevance 0
A significant decrease in NR1 expression also occurred in the piriform cortex.
Negative_regulation (decrease) of Gene_expression (expression) of NR1 in piriform cortex
3) Confidence 0.57 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.69 Pain Relevance 0.50
One week of tetrodotoxin significantly decreased the expression of NMDAR1, nNOS, and CO activity.
Negative_regulation (decreased) of Gene_expression (expression) of NMDAR1 associated with tetrodotoxin
4) Confidence 0.56 Published 1999 Journal J. Neurocytol. Section Abstract Doc Link 10800203 Disease Relevance 0 Pain Relevance 0.37
At 1.5 and 3 h recirculation, autoradiography showed pronounced but differential decreases in AMPA, NR1 and preproenkephalin messenger RNA expression throughout the infarcted ipsilateral striatum.
Negative_regulation (decreases) of Gene_expression (expression) of NR1 in striatum
5) Confidence 0.53 Published 2000 Journal Neuroscience Section Abstract Doc Link 10670452 Disease Relevance 0.57 Pain Relevance 0.24
Intrathecal co-infusion of ultra-low dose naloxone (15pg/h) with morphine attenuated tolerance development, reversed GTs expression, inhibited the NMDAR NR1 subunit expression and phosphorylation, and PKCgamma expression, inhibited glial cell activation, and suppressed the morphine-evoked EAAs release.
Negative_regulation (inhibited) of Gene_expression (expression) of NMDAR NR1 subunit in glial cell associated with tolerance, narcan, excitatory amino acid, morphine and intrathecal
6) Confidence 0.50 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20478329 Disease Relevance 0 Pain Relevance 1.85
Chronic treatments markedly reduced the expression level of NR1 subunit in synaptic membranes.
Negative_regulation (reduced) of Gene_expression (expression) of NR1
7) Confidence 0.47 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17543354 Disease Relevance 0 Pain Relevance 0.93
RESULTS: Single dose of morphine was followed by a decrease in gene expression of glutamate receptor subunit NMDAR1 in the adrenal gland.
Negative_regulation (decrease) of Gene_expression (expression) of NMDAR1 in adrenal gland
8) Confidence 0.46 Published 2001 Journal Endocr Regul Section Body Doc Link 11858765 Disease Relevance 0 Pain Relevance 0
Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats.
Negative_regulation (effects) of Gene_expression (expression) of NR1 subunit associated with nmda receptor, antagonist, glutamate receptor and morphine
9) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.54
In addition, the elevation of NR1 expression by morphine was decreased by the coadministration of nalbuphine in rat cortex.
Negative_regulation (decreased) of Gene_expression (expression) of NR1 in cortex associated with nalbuphine and morphine
10) Confidence 0.43 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 16964763 Disease Relevance 0.32 Pain Relevance 2.56
The magnitude of the nocifensive behavior and NMDAR1 expression were both force magnitude dependent and could be reduced by peripheral NMDA receptor antagonist MK-801.
Negative_regulation (reduced) of Gene_expression (expression) of NMDAR1
11) Confidence 0.43 Published 2009 Journal Angle Orthod Section Body Doc Link 19705939 Disease Relevance 0.06 Pain Relevance 0
We determined whether the i.t. administration of an 18-mer phosphodiester antisense oligodeoxynucleotide (ODN) that reduces the expression of the rat NMDAR1 subunit of the N-methyl-d-aspartate (NMDA) receptor would affect nociceptive behaviors and prevent the development of morphine tolerance.
Negative_regulation (reduces) of Gene_expression (expression) of NMDAR1 subunit associated with nociception, tolerance and morphine
12) Confidence 0.43 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15388787 Disease Relevance 0.41 Pain Relevance 0.50
The delay in NR1 expression could suggest that NMDA receptor may be involved in chronic nociception and may well persist following resolution of the colitis.
Negative_regulation (delay) of Gene_expression (expression) of NR1 associated with colitis, nociception and nmda receptor
13) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.86 Pain Relevance 0.29
The phosphorylation levels of GluR1 and NR1 subunits decreased in parallel with those of phospho-Thr-34 DARPP-32, supporting the hypothesis that morphine challenge elicited a decrease in PKA activity in morphine-sensitized rats.
Negative_regulation (decreased) of Gene_expression (levels) of NR1 associated with morphine
14) Confidence 0.42 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.03
Immunocytochemistry revealed a toxin-induced reduction in lamina I, of SPR and of NMDA NR1 subunit receptor expressing neurons, and of c-Fos, an inducible molecular marker of persistent nociceptive activity.
Negative_regulation (reduction) of Gene_expression (expressing) of NR1 in neurons associated with nociception
15) Confidence 0.41 Published 1999 Journal Pain Section Abstract Doc Link 10068170 Disease Relevance 1.19 Pain Relevance 1.16
Masseter inflammation significantly down-regulated NR1 subunit expression that persisted to 7 days post-CFA inflammation.
Negative_regulation (down-regulated) of Gene_expression (expression) of NR1 subunit in Masseter associated with inflammation
16) Confidence 0.41 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.70 Pain Relevance 0.58
In morphine-dependent rats, the expression of NR1 and NR2A subunits protein, as determined by Western blotting with NMDA receptor subunit antibodies, were decreased in frontal cortex and hippocampus but significantly increased in the nucleus accumbens.
Negative_regulation (decreased) of Gene_expression (expression) of NR1 in hippocampus associated with nucleus accumbens, nmda receptor, urological neuroanatomy, hippocampus and morphine
17) Confidence 0.39 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17321516 Disease Relevance 0.18 Pain Relevance 1.02
The expression of the NMDAR1 increased gradually to reach the peak at day 7 after DRGn (mean right/left IOD ratio=1.52), then decreased thereafter.
Negative_regulation (decreased) of Gene_expression (expression) of NMDAR1 associated with ganglionectomy
18) Confidence 0.38 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10822148 Disease Relevance 0 Pain Relevance 0.77
Intrathecal coadministration of morphine with an adenylyl cyclase inhibitor (2',5'-dideoxyadenosine) or a protein kinase A inhibitor (H89) also significantly attenuated morphine-induced NR1 and PKCgamma expression, whereas intrathecal treatment with an adenylyl cyclase activator (forskolin) alone mimicked morphine-induced expression of GR, NR1, and PKCgamma.
Negative_regulation (mimicked) of Gene_expression (expression) of NR1 associated with morphine and intrathecal
19) Confidence 0.37 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.52
Intrathecal coadministration of morphine with an adenylyl cyclase inhibitor (2',5'-dideoxyadenosine) or a protein kinase A inhibitor (H89) also significantly attenuated morphine-induced NR1 and PKCgamma expression, whereas intrathecal treatment with an adenylyl cyclase activator (forskolin) alone mimicked morphine-induced expression of GR, NR1, and PKCgamma.
Negative_regulation (attenuated) of Gene_expression (expression) of NR1 associated with morphine and intrathecal
20) Confidence 0.37 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.45

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