INT80473

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.76
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Spr) oxidoreductase activity (Spr) nucleolus (Spr)
nucleus (Spr) cellular_component (Spr) cytoplasm (Spr)
Anatomy Link Frequency
PSNs 2
Spr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 24 99.08 Very High Very High Very High
Dorsal horn neuron 8 97.40 Very High Very High Very High
Lasting pain 6 96.40 Very High Very High Very High
Hyperalgesia 8 94.96 High High
intrathecal 4 94.24 High High
allodynia 4 94.04 High High
Glutamate 4 93.76 High High
Pain 12 92.00 High High
Spinal cord 4 91.88 High High
Dorsal horn 6 91.08 High High
Disease Link Frequency Relevance Heat
Nociception 8 99.68 Very High Very High Very High
Pain 10 96.40 Very High Very High Very High
Hyperalgesia 8 94.96 High High
Neuropathic Pain 6 94.04 High High
Diphtheria 4 93.96 High High
Pressure And Volume Under Development 2 91.68 High High
INFLAMMATION 2 90.92 High High
Injury 2 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DAB389SP binds to the SP receptor (SPR) and is internalized and kills SPR-expressing cells by blocking cellular protein synthesis.
Gene_expression (expressing) of SPR associated with substance p
1) Confidence 0.46 Published 1999 Journal Pain Section Abstract Doc Link 10068170 Disease Relevance 1.03 Pain Relevance 1.04
The present study was performed to investigate the changes in SPR and NMDAR mRNA expressions during nociception in rats.
Gene_expression (expressions) of SPR associated with nociception
2) Confidence 0.42 Published 2002 Journal Ann. Anat. Section Abstract Doc Link 11876485 Disease Relevance 0.28 Pain Relevance 0.79
These combined data suggest that MSP9 activates multiple opioid- and SPR-expressing systems functionally linked to CNS analgesic responses, designating this class of hybrid chimeric molecules as prime candidates for therapeutic development for a wide range of clinical indications.


Gene_expression (expressing) of SPR
3) Confidence 0.39 Published 2007 Journal Med. Sci. Monit. Section Body Doc Link 17261977 Disease Relevance 0 Pain Relevance 0
CFA injection increased SPR mRNA expression in PSNs at days 1 and 4, and NMDAR mRNA expression at days 1, 4 and 7.
Gene_expression (expression) of SPR in PSNs
4) Confidence 0.37 Published 2002 Journal Ann. Anat. Section Abstract Doc Link 11876485 Disease Relevance 0.26 Pain Relevance 0.88
Immunocytochemistry revealed a toxin-induced reduction in lamina I, of SPR and of NMDA NR1 subunit receptor expressing neurons, and of c-Fos, an inducible molecular marker of persistent nociceptive activity.
Gene_expression (expressing) of SPR in neurons associated with nociception
5) Confidence 0.35 Published 1999 Journal Pain Section Abstract Doc Link 10068170 Disease Relevance 1.18 Pain Relevance 1.15

General Comments

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