INT8048

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Context Info
Confidence 0.74
First Reported 1981
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 45
Total Number 46
Disease Relevance 8.90
Pain Relevance 21.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
neurons 3
tail 2
SCN 2
RVM 2
nerve 2
Nts (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 185 100.00 Very High Very High Very High
Enkephalin 40 100.00 Very High Very High Very High
Neuropeptide 28 100.00 Very High Very High Very High
gABA 26 100.00 Very High Very High Very High
qutenza 13 100.00 Very High Very High Very High
bradykinin 10 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
dopamine receptor 1 100.00 Very High Very High Very High
antinociception 31 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Catalepsy 3 99.96 Very High Very High Very High
Clostridium Infection 1 99.84 Very High Very High Very High
Stress 66 99.80 Very High Very High Very High
Anorexia 28 99.48 Very High Very High Very High
Targeted Disruption 10 99.40 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 5 98.90 Very High Very High Very High
Pain 92 98.68 Very High Very High Very High
Urological Neuroanatomy 10 98.44 Very High Very High Very High
Hyperalgesia 4 98.28 Very High Very High Very High
Ganglion Cysts 58 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the synthesis of NPY, ENK and NT is enhanced in TIDA neurons during lactation and that these neuromessengers may be co-released together with DA from the ME to regulate the suckling-induced prolactin secretion at the hypothalamic and/or pituitary levels.
Gene_expression (synthesis) of NT in neurons associated with enkephalin
1) Confidence 0.74 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.09 Pain Relevance 0.63
The intracerebroventricular administration of the tridecapeptide neurotensin (NT) produces strong analgesic effects in tests evaluating acute pain.
Gene_expression (produces) of tridecapeptide neurotensin associated with acute pain, analgesic and intracerebroventricular
2) Confidence 0.71 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 17074405 Disease Relevance 0.17 Pain Relevance 0.54
The intracerebroventricular administration of the tridecapeptide neurotensin (NT) produces strong analgesic effects in tests evaluating acute pain.
Gene_expression (produces) of NT associated with acute pain, analgesic and intracerebroventricular
3) Confidence 0.71 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 17074405 Disease Relevance 0.17 Pain Relevance 0.54
Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity and of the response elicited by subcutaneous hypertonic saline.
Gene_expression (produced) of neurotensin associated with eae and intrathecal
4) Confidence 0.68 Published 1983 Journal Peptides Section Abstract Doc Link 6196760 Disease Relevance 0.07 Pain Relevance 0.61
The central administration of neurotensin (NT) or of its C-terminal hexapeptide fragment NT(8-13), produces strong analgesic effects in tests evaluating acute pain.
Gene_expression (produces) of neurotensin associated with acute pain and analgesic
5) Confidence 0.67 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18321036 Disease Relevance 0.19 Pain Relevance 0.38
Intracerebral injection of neurotensin into specific brain loci in rats produces hyperalgesia due to the release of cholecystokinin (CCK) in the spinal cord.
Gene_expression (injection) of neurotensin in brain associated with hyperalgesia, cholecystokinin and spinal cord
6) Confidence 0.63 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10202849 Disease Relevance 0.10 Pain Relevance 0.64
We further show that downstream striatal correlates of the midbrain neuronal losses in aphakia mice, as assessed by dopamine transporter binding and expression of dopamine receptors, enkephalin, dynorphin and neurotensin, are highly similar to neuroadaptive responses observed following rapid neurodegeneration induced by neurotoxin administration in adult animals or following the progressive neurodegenerative processes as seen in Parkinson patients.
Gene_expression (expression) of neurotensin in neuronal associated with dopamine, dynorphin, dopamine receptor, ocular toxicity (including many sub-types), enkephalin, midbrain and neurodegenerative disease
7) Confidence 0.61 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16269007 Disease Relevance 0.74 Pain Relevance 0.45
The central administration of neurotensin (NT) or of its C-terminal hexapeptide fragment NT(8-13), produces strong analgesic effects in tests evaluating acute pain.
Gene_expression (produces) of NT associated with acute pain and analgesic
8) Confidence 0.59 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18321036 Disease Relevance 0.19 Pain Relevance 0.38
Neurotensin (NT), administered intracisternally to mice, produced significant dose-dependent antinociception in three analgesic tests: tail immersion, hot-plate and acetic acid writhing.
Gene_expression (produced) of Neurotensin in tail associated with antinociception and analgesic
9) Confidence 0.58 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6112261 Disease Relevance 0 Pain Relevance 0.70
Plasticity in expression of immunoreactivity for neuropeptide Y, enkephalins and neurotensin in the hypothalamic tubero-infundibular dopaminergic system during lactation in mice.
Gene_expression (expression) of neurotensin associated with neuropeptide and enkephalin
10) Confidence 0.57 Published 1993 Journal J. Neuroendocrinol. Section Title Doc Link 8680430 Disease Relevance 0.07 Pain Relevance 0.76
Neurotensin (NT) can produce a profound analgesia or enhance pain responses, depending on the circumstances.
Gene_expression (produce) of Neurotensin associated with pain and analgesia
11) Confidence 0.57 Published 2006 Journal Peptides Section Abstract Doc Link 16870306 Disease Relevance 0.95 Pain Relevance 0.60
These data suggest that the level of activity of the neuron regulates NT supply to the axon terminals, presumably by regulating NT synthesis.
Gene_expression (synthesis) of NT in neuron
12) Confidence 0.52 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004440 Disease Relevance 0.25 Pain Relevance 0.18
Up to high doses, neurotensin (5.0 and 10.0 micrograms, i.c.v.) and NT1 (10.0 and 20.0 mg/kg, i.p.) did not produce catalepsy.
Neg (not) Gene_expression (produce) of neurotensin associated with catalepsy
13) Confidence 0.52 Published 1997 Journal Peptides Section Abstract Doc Link 9396065 Disease Relevance 0.17 Pain Relevance 0.43
NPY-, ENK- and NT-irs were intensely expressed and coexisted in virtually all TH-ir endings in the median eminence (ME) of nursing mice.
Gene_expression (expressed) of NT in median eminence associated with enkephalin
14) Confidence 0.50 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.08 Pain Relevance 0.66
Neurotensin given intracerebroventricularly (i.c.v.) at doses higher than 100 ng produced antinociception in the tail flick test.
Gene_expression (produced) of Neurotensin in tail associated with antinociception and tail-flick
15) Confidence 0.49 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10202849 Disease Relevance 0.09 Pain Relevance 0.94
In previous reports, we have demonstrated that intracisternal (IC) administration of neurotensin (NT), an endogenous tridecapeptide, produces significant antinociception in a variety of analgesic tests, including the hot-plate test.
Gene_expression (produces) of neurotensin associated with antinociception and analgesic
16) Confidence 0.48 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3703880 Disease Relevance 0.09 Pain Relevance 0.73
Neurotensin (10(-11) M to 10(-7) M) produced dose-dependent tonic contractions and showed a higher affinity but lower efficiency compared to acetylcholine (ACH).
Gene_expression (produced) of Neurotensin
17) Confidence 0.39 Published 1987 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 3439476 Disease Relevance 0 Pain Relevance 0.09
Similarly, injection of the CART peptide either into the third, fourth, or the lateral ventricle suppressed food intake [11,12,14,19,20] and stimulated expression of c-Fos in NTS, the parabranchial nucleus, PVN and DMH [21,22].
Gene_expression (expression) of NTS in lateral ventricle associated with medulla
18) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.29 Pain Relevance 0.86
In this study, the Fos immunoreactivity after injection of the CART peptide or/and CCK-8 was determined in NTS, PVN, and DMH, common targets of CART peptide [21,22] and CCK [5,15-18], in the identical set of mice.
Spec (determined) Gene_expression (determined) of NTS associated with medulla and cholecystokinin
19) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.65
In addition, NT was not found or only negligible numbers of cells were seen outside the lower small intestine.
Neg (not) Gene_expression (found) of NT in small intestine
20) Confidence 0.33 Published 1989 Journal Nippon Geka Hokan Section Abstract Doc Link 2642265 Disease Relevance 0 Pain Relevance 0

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