INT80486

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 10.42
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (FECH) mitochondrion (FECH) small molecule metabolic process (FECH)
Anatomy Link Frequency
muscle 2
skin 1
FECH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 542 99.84 Very High Very High Very High
backache 48 99.52 Very High Very High Very High
Lasting pain 6 99.28 Very High Very High Very High
Glutamate 4 70.40 Quite High
fibrosis 4 69.92 Quite High
Inflammation 8 67.32 Quite High
Chronic low back pain 71 66.32 Quite High
rheumatoid arthritis 1 50.00 Quite Low
spinal inflammation 1 50.00 Quite Low
Arthritis 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Erythropoietic Protoporphyria 201 100.00 Very High Very High Very High
Pain 498 99.84 Very High Very High Very High
Low Back Pain 161 99.52 Very High Very High Very High
Sunburn 63 97.20 Very High Very High Very High
Iron Overload 100 97.04 Very High Very High Very High
Liver Disease 53 93.72 High High
Respiratory Distress 2 91.76 High High
Anxiety Disorder 100 91.44 High High
Neuropathy 2 89.76 High High
Disease 150 88.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study we found a symptom increase in 82% of all subjects and a normalization of pain to pre-FCE levels on the third day following the FCE (Fig. 2).
Gene_expression (levels) of FCE associated with pain
1) Confidence 0.54 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2522381 Disease Relevance 1.12 Pain Relevance 1.06
In our study we found a symptom increase in 82% of all subjects and a normalization of pain to pre-FCE levels on the third day following the FCE (Fig. 2).
Gene_expression (levels) of FCE associated with pain
2) Confidence 0.54 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2522381 Disease Relevance 1.13 Pain Relevance 1.06
S cluster biogenesis, the heme synthetic enzyme ferrochelatase (FECH) is unstable and is significantly degraded in patient muscle (69).
Gene_expression (synthetic) of ferrochelatase in muscle
3) Confidence 0.52 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.24 Pain Relevance 0.03
S cluster biogenesis, the heme synthetic enzyme ferrochelatase (FECH) is unstable and is significantly degraded in patient muscle (69).
Gene_expression (synthetic) of FECH in muscle
4) Confidence 0.52 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.24 Pain Relevance 0.04
Theoretically, if this happened, we should have seen an increased strength of correlations between specific SE and performances along progression of the FCE (test sequence: lifting low, lifting high, carry).
Gene_expression (progression) of FCE
5) Confidence 0.48 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2668547 Disease Relevance 0.08 Pain Relevance 0.08
Further research is needed in different settings and countries, because this will enable us to unravel the important question of ‘what exactly is being measured in FCE’?
Gene_expression (measured) of FCE
6) Confidence 0.48 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2668547 Disease Relevance 0.23 Pain Relevance 0.05
The current study and our previous study show that report of pain and pain related fears explain little of the patient's performances during FCE.
Gene_expression (explain) of FCE associated with pain
7) Confidence 0.46 Published 2007 Journal J Occup Rehabil Section Body Doc Link PMC1915618 Disease Relevance 1.10 Pain Relevance 0.83
The strength of the significant associations between pain intensity and FCE performances in patients with chronic pain vary from r = ?
Gene_expression (performances) of FCE associated with pain and lasting pain
8) Confidence 0.46 Published 2007 Journal J Occup Rehabil Section Body Doc Link PMC1915618 Disease Relevance 1.51 Pain Relevance 1.08
S cluster biogenesis severely diminishes FECH protein levels (69), there might be some cases of EPP in human patients caused by deficient Fe?
Gene_expression (cases) of EPP associated with erythropoietic protoporphyria
9) Confidence 0.45 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.70 Pain Relevance 0.09
Finally, because FECH deficiency causes erythropoietic protoporphyria (EPP), manifesting painful skin photosensitivity due to protoporphyrin accumulation (92), and deficient Fe?
Gene_expression (deficiency) of FECH in skin associated with pain, sunburn and erythropoietic protoporphyria
10) Confidence 0.45 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.80 Pain Relevance 0.10
The scores on most questionnaires were normally distributed, except for duration of low back pain episode, the subscales expression of emotions and passive coping of the UCL and the static forward bend test of the FCE.
Gene_expression (expression) of FCE associated with low back pain and backache
11) Confidence 0.32 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2583191 Disease Relevance 0.23 Pain Relevance 0.23
The primary aim of this pilot study was to provide proof that the FCE is present in the perception of doping behaviour.
Gene_expression (present) of FCE
12) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2553062 Disease Relevance 0 Pain Relevance 0
The discovery that clinical expression of this type of EPP normally required a hypomorphic FECH IVS3-48C allele trans to the mutation was demonstrated in France [26,31] and was independently confirmed by studies from Japan, North America, Sweden, Israel, South Africa, the United Kingdom [28,30-34].
Gene_expression (expression) of EPP associated with erythropoietic protoporphyria
13) Confidence 0.14 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 0.92 Pain Relevance 0.07
We now show that (1) coinheritance of a FECH gene defect and a wild-type low-expressed allele is generally involved in the clinical expression of EPP; (2) the low-expressed allelic variant was strongly associated with a partial 5' haplotype [-251G IVS1-23T IVS2microsatA9] that may be ancestral and was present in an estimated 10% of a control group of Caucasian origin; and (3) haplotyping allows the absolute risk of developing the disease to be predicted for those inheriting FECH EPP mutations.
Gene_expression (expression) of EPP associated with erythropoietic protoporphyria and disease
14) Confidence 0.12 Published 1999 Journal Blood Section Abstract Doc Link 10068685 Disease Relevance 0.99 Pain Relevance 0.07
Pathological features of EPP
Gene_expression (features) of EPP associated with erythropoietic protoporphyria
15) Confidence 0.11 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 1.06 Pain Relevance 0
Comparison of FCE was made with lectin binding analysis in which the lectins Ricinus communis (RCA1) and Bandeiraea simplicifolia (BSII) were used to detect galactose (Gal) and N-acetylglucosamine (GlcNAc), respectively.
Gene_expression (made) of FCE
16) Confidence 0.06 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11469458 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox