INT8049

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Context Info
Confidence 0.53
First Reported 1984
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 18
Total Number 22
Disease Relevance 6.15
Pain Relevance 10.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
brainstem 2
cell body 2
neurons 2
stellate ganglion 1
spinal cord 1
Nts (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 305 100.00 Very High Very High Very High
medulla 137 100.00 Very High Very High Very High
Dopamine 43 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
Pain 18 100.00 Very High Very High Very High
Neuropeptide 12 100.00 Very High Very High Very High
Somatostatin 9 100.00 Very High Very High Very High
nociceptor 3 100.00 Very High Very High Very High
spinal-cord stimulation 3 99.98 Very High Very High Very High
substance P 4 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 17 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
Stress 38 99.84 Very High Very High Very High
Shock 3 99.60 Very High Very High Very High
Coronary Artery Disease 2 95.92 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.00 High High
Endocrine Disease 1 92.68 High High
Targeted Disruption 5 90.24 High High
Nociception 1 88.48 High High
INFLAMMATION 1 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the level of activity of the neuron regulates NT supply to the axon terminals, presumably by regulating NT synthesis.
Regulation (regulates) of NT in neuron
1) Confidence 0.53 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004440 Disease Relevance 0.26 Pain Relevance 0.18
Plasticity in expression of immunoreactivity for neuropeptide Y, enkephalins and neurotensin in the hypothalamic tubero-infundibular dopaminergic system during lactation in mice.
Regulation (immunoreactivity) of neurotensin associated with neuropeptide and enkephalin
2) Confidence 0.43 Published 1993 Journal J. Neuroendocrinol. Section Title Doc Link 8680430 Disease Relevance 0.07 Pain Relevance 0.76
Atropine and tetrodotoxin had no effect on the neurotensin responses.
Neg (no) Regulation (effect) of neurotensin associated with tetrodotoxin
3) Confidence 0.40 Published 1987 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 3439476 Disease Relevance 0 Pain Relevance 0.10
Slices of caudate-putamen (CP) and nucleus accumbens (NA) prepared from Long-Sleep (LS) and Short-Sleep (SS) mice were used to determine the effects of neurotensin (NT) and ethanol on K(+)-stimulated 3H-dopamine (3H-DA) release and to test the hypothesis that ethanol acts, in part, via NT receptor-mediated processes.
Spec (determine) Regulation (effects) of neurotensin in caudate-putamen associated with nucleus accumbens and dopamine
4) Confidence 0.38 Published 1992 Journal Alcohol Section Abstract Doc Link 1733422 Disease Relevance 0 Pain Relevance 0.32
We have previously shown that the neurotensin (NT) store in preganglionic axon terminals of the cat stellate ganglion (SG) is reversibly depleted by prolonged preganglionic stimulation.
Regulation (depleted) of neurotensin in stellate ganglion associated with ganglion cysts
5) Confidence 0.34 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004441 Disease Relevance 0.35 Pain Relevance 0.10
It is concluded that neurotensin modulates in an opposite way the function of the enkephalinergic neurons and the central action of tuftsin.
Regulation (modulates) of neurotensin in neurons
6) Confidence 0.27 Published 1984 Journal Acta Physiol Pol Section Abstract Doc Link 6545985 Disease Relevance 0 Pain Relevance 0.58
This study determined the effects of neurokinin-1 (NK1) receptor blockade on: (i) the reflex response evoked following aortic root injection of either veratridine (1-3 microg/kg) or bradykinin (80-300 ng/kg) to stimulate cardiac receptors in in vivo anaesthetized mice; and (ii) the evoked synaptic response of cardioreceptive NTS neurons following both intraleft-ventricular injection of veratridine or bradykinin, and electrical stimulation of the ipsilateral vagus nerve in an arterially perfused working heart-brainstem preparation of mouse.
Regulation (response) of NTS in brainstem associated with medulla, vagus nerve and bradykinin
7) Confidence 0.23 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9749755 Disease Relevance 0.07 Pain Relevance 0.35
Neurotensin and pain modulation.
Regulation (modulation) of Neurotensin associated with pain and nociceptor
8) Confidence 0.22 Published 2006 Journal Peptides Section Title Doc Link 16870306 Disease Relevance 1.40 Pain Relevance 1.22
A considerable amount of data implicates NT in thyroid-related regulation through this circuit, the exact mechanisms of which should be further investigated for the potential development of more targeted approaches towards the treatment of thyroid-related endocrine diseases.
Regulation (regulation) of NT in thyroid associated with endocrine disease
9) Confidence 0.22 Published 2010 Journal Neuropeptides Section Abstract Doc Link 19878995 Disease Relevance 0.76 Pain Relevance 0.17
However, neither an NTR1 antagonist, SR48692, an NTR2 antagonist, levocabastine, nor the two combined affected the basal level and the neurotensin-mediated decrease in DARPP-32 Thr75 phosphorylation.
Regulation (affected) of neurotensin associated with antagonist
10) Confidence 0.20 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.44
Effects of cerebroventricular and/or intravenous infusions of neurotensin (NT), an endogenous tridecapeptide, on haemodynamics and renal function were investigated in chloralose anaesthetized dogs. 2.
Spec (investigated) Regulation (Effects) of NT
11) Confidence 0.18 Published 1990 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2390805 Disease Relevance 0 Pain Relevance 0
The distinct topography of conditioned versus unconditioned stress on the concentration of NT-LI in the dopamine cell body groups of the ventral mesencephalon suggests that NT may be involved in the differential activation of distinct dopamine neuronal populations by these different stressors.
Regulation (concentration) of NT in cell body associated with stress and dopamine
12) Confidence 0.15 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1361117 Disease Relevance 0.42 Pain Relevance 0.51
Lacking NT receptor antagonists, it would also be of interest to determine the effects of the passive immunoneutralization of NT in the ventral mesencephalon on footshock-induced increases in the biochemically estimated activity of mesotelencephalic dopamine neurons to better understand the involvement of NT as a transducer of the effects of stress on dopamine neuronal activity.
Regulation (effects) of NT in ventral associated with stress, dopamine and antagonist
13) Confidence 0.15 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1361117 Disease Relevance 0.53 Pain Relevance 0.59
An identical set of mice was used for determination of Fos immunoreactivity in NTS, PVN, and DMH.
Regulation (immunoreactivity) of NTS associated with medulla
14) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.10
In this study, the synergistic effect of CCK and CART peptide on food intake targeted hypothalamic PVN and DMH and NTS, which suggested that CART peptide might act as a mediator of the leptin anorexigenic effect both in the hypothalamus and brainstem.
Regulation (targeted) of NTS in brainstem associated with medulla and cholecystokinin
15) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.22 Pain Relevance 0.64
None of the other neuropeptides measure, substance P, neurotensin, or [met5]-enkephalin was altered by nicotine treatment.
Regulation (altered) of neurotensin associated with nicotine, neuropeptide, enkephalin and substance p
16) Confidence 0.12 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2412241 Disease Relevance 0 Pain Relevance 0.43
However, it should be noted that populations of dopamine neurons are activated by footshock intensities less than 500 microA, while NT concentrations of mesencephalic dopamine cell body groups are not altered by these shock intensities.
Neg (not) Regulation (altered) of NT in cell body associated with dopamine and shock
17) Confidence 0.09 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1361117 Disease Relevance 0.44 Pain Relevance 0.29
Choline acetyltransferase (ChAT), Met-ENK, and NT immunoreactivity was detected with light microscopy in axon terminals near tyrosine hydroxylase (TH) immunoreactive (IR) cells.
Regulation (immunoreactivity) of NT
18) Confidence 0.08 Published 2002 Journal Synapse Section Abstract Doc Link 11793421 Disease Relevance 0.13 Pain Relevance 0.16
The role of POMC neurones in the NTS and vagal afferents to both sets of POMC cell bodies requires further study.
Regulation (role) of NTS associated with medulla
19) Confidence 0.06 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.94
This effect of CCK activating POMC "GFP" NTS neurones is blocked by a CCK antagonist and also antagonised by endogenous opioids [89].
Regulation (effect) of NTS associated with medulla, antagonist, endogenous opioid and cholecystokinin
20) Confidence 0.06 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.31 Pain Relevance 0.87

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