INT80498

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 7.06
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DSP) structural molecule activity (DSP) plasma membrane (DSP)
protein binding, bridging (DSP) cytoplasm (DSP)
Anatomy Link Frequency
plaque 2
plasma 1
spinal 1
longitudinal muscle 1
DSP (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 3 98.28 Very High Very High Very High
analgesia 2 97.48 Very High Very High Very High
tail-flick 1 96.64 Very High Very High Very High
addiction 13 95.92 Very High Very High Very High
MU agonist 1 92.48 High High
GABAergic 40 74.96 Quite High
Analgesic 4 68.64 Quite High
headache 7 62.16 Quite High
cva 10 55.68 Quite High
Action potential 7 55.12 Quite High
Disease Link Frequency Relevance Heat
Neuropathy 290 100.00 Very High Very High Very High
Infection 37 100.00 Very High Very High Very High
Breast Cancer 172 99.04 Very High Very High Very High
Immunotherapy Of Cancer 3 93.68 High High
Cancer 126 93.64 High High
Neurodegenerative Disease 18 91.52 High High
Carcinoma 22 85.20 High High
Necrosis 7 84.24 Quite High
Metastasis 6 83.12 Quite High
Salivary Gland Disease 4 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the epidermis, the plaque proteins plakoglobin, desmoplakin and plakophilin 3 are expressed in all layers (Fig. 4).
Gene_expression (expressed) of desmoplakin in plaque
1) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
This view seemed to be supported by immuno-localization studies, which showed that desmoplakin as a desmosomal marker and the myocardial adherens junction protein N-cadherin displayed mutually exclusive spatial distribution patterns (Angst et al. 1997; Gutstein et al. 2003).
Gene_expression (marker) of desmoplakin
2) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
One report on a case of desmoplakin mutation, a protein found in the desmosomal plaque, showed desmosomes without anchoring keratin filaments10, similar to the free desmosomes found in this research, which suggests that desmoplakin may also be damaged in PPD.



Gene_expression (damaged) of desmoplakin in plaque
3) Confidence 0.65 Published 2008 Journal Clinics Section Body Doc Link PMC2664235 Disease Relevance 0.43 Pain Relevance 0
However, a recent comprehensive set of studies unequivocally demonstrated that the desmosomal components desmoglein 2 (Dsg 2), desmocollin 2 (Dsc 2), desmoplakin and plakophilin-2 as well as the adherens junction components N-cadherin, cadherin-11, ?
Gene_expression (components) of desmoplakin
4) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
This can be concluded from experiments in which expression of N-terminally deleted Dsc 3 or desmoplakin deficiency resulted in impaired formation of both desmosomes and adherens junctions (Hanakawa et al. 2000; Vasioukhin et al. 2001).


Gene_expression (expression) of desmoplakin
5) Confidence 0.58 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.07 Pain Relevance 0.05
Prior to cervical spinal radiography, treating physicians evaluated each patient to determine whether a DPI was present or absent and, if present, what type of injury was sustained.
Neg (absent) Gene_expression (absent) of DPI in spinal
6) Confidence 0.52 Published 2001 Journal Acad Emerg Med Section Body Doc Link 11136143 Disease Relevance 0 Pain Relevance 0
A consistent trend was observed for better improvement in patients treated with MF DPI 200 mcg b.i.d. than with MF DPI 100 mcg b.i.d., with no apparent additional benefit of MF DPI 400 mcg b.i.d.
Gene_expression (b.i.d.) of DPI
7) Confidence 0.30 Published 1999 Journal Respir Med Section Abstract Doc Link 10542973 Disease Relevance 0.34 Pain Relevance 0.06
The expression of desmoplakin 1&2 was similar to that of connexin43, with punctate staining seen along the plasma membrane of two adjoining cells (Figure 2E, white arrows).
Gene_expression (expression) of desmoplakin in plasma
8) Confidence 0.18 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
WalBC cells showed regulated expression of DSP, s100A14 and ANXA1 which are genes associated with well-differentiated, epithelioid breast cancer cell lines with weak invasive potential and poorly invasive tumors [45-47].
Gene_expression (expression) of DSP associated with cancer and breast cancer
9) Confidence 0.18 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.91 Pain Relevance 0
The cultures also expressed the junctional proteins connexin43, desmoplakin 1 and 2, E-cadherin, and zonula occludens-1.
Gene_expression (expressed) of desmoplakin
10) Confidence 0.16 Published 2005 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC1285366 Disease Relevance 0.17 Pain Relevance 0.08
Subgroups were based on the bilateral averaged VPT (VPT-AVG): Group 1) no signs of DSP: 0-15 V; Group 2) signs of mild DSP: >15-25 V; Group 3) signs of moderate DSP: >25-50 V; and Group 4) signs of severe DSP: >50 V.
Gene_expression (signs) of DSP associated with neuropathy
11) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.66 Pain Relevance 0
Subgroups were based on the bilateral averaged VPT (VPT-AVG): Group 1) no signs of DSP: 0-15 V; Group 2) signs of mild DSP: >15-25 V; Group 3) signs of moderate DSP: >25-50 V; and Group 4) signs of severe DSP: >50 V.
Gene_expression (signs) of DSP associated with neuropathy
12) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.66 Pain Relevance 0
The three clinical measurement tools used to identify signs of DSP (VPT, MDNS, MNSIc) were highly correlated (>0.70 correlation coefficient).
Gene_expression (signs) of DSP associated with neuropathy
13) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.88 Pain Relevance 0
Subgroups were based on the bilateral averaged VPT (VPT-AVG): Group 1) no signs of DSP: 0-15 V; Group 2) signs of mild DSP: >15-25 V; Group 3) signs of moderate DSP: >25-50 V; and Group 4) signs of severe DSP: >50 V.
Gene_expression (signs) of DSP associated with neuropathy
14) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.66 Pain Relevance 0
Subgroups were based on the bilateral averaged VPT (VPT-AVG): Group 1) no signs of DSP: 0-15 V; Group 2) signs of mild DSP: >15-25 V; Group 3) signs of moderate DSP: >25-50 V; and Group 4) signs of severe DSP: >50 V.
Gene_expression (signs) of DSP associated with neuropathy
15) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.66 Pain Relevance 0
Notably WalBC cells showed up regulated expression of DSP, s100A4, ANXA1, NDRG-1, TK1 and down regulation of genes such as tissue inhibitor of TIMP-3 and TAGLN.
Gene_expression (expression) of DSP
16) Confidence 0.14 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.39 Pain Relevance 0
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Gene_expression (expression) of DSP associated with breast cancer
17) Confidence 0.14 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.81 Pain Relevance 0
III tubulin or MAP2 expression (35.9%±13.0% at 10.7±2.0 DPI, n?
Gene_expression (expression) of DPI associated with infection
18) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.34 Pain Relevance 0.13
The dipeptidyl aminopeptidase IV (DP IV) inhibitor Diprotin A produces a full, dose-dependent, short-lasting and naloxone-reversible analgesia in the rat tail-flick test when given intracerebroventricularly, with an ED50 of 295 nmol/rat but it has no direct opioid agonist activity in the longitudinal muscle strip of guinea-pig ileum bioassay.
Gene_expression (produces) of DP IV in longitudinal muscle associated with mu agonist, tail-flick, narcan and analgesia
19) Confidence 0.00 Published 1999 Journal Life Sci. Section Abstract Doc Link 10069492 Disease Relevance 0 Pain Relevance 0.47

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