INT8050

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Context Info
Confidence 0.66
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.31
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
right lobe 4
hippocampus 3
vagus nerve 2
brain 2
cell body 2
Nts (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 104 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
Cholecystokinin 112 99.84 Very High Very High Very High
vagus nerve 27 98.56 Very High Very High Very High
Hyperalgesia 1 98.28 Very High Very High Very High
Dopamine 16 98.08 Very High Very High Very High
Neuropeptide 14 98.00 Very High Very High Very High
agonist 41 97.62 Very High Very High Very High
Spinal cord 21 95.72 Very High Very High Very High
Endogenous opioid 2 93.32 High High
Disease Link Frequency Relevance Heat
Stress 47 99.98 Very High Very High Very High
Anorexia 14 99.84 Very High Very High Very High
Targeted Disruption 5 99.64 Very High Very High Very High
Hyperalgesia 1 98.28 Very High Very High Very High
Porphyria 95 97.70 Very High Very High Very High
Catalepsy 2 97.20 Very High Very High Very High
Aids-related Complex 7 87.64 High High
Body Weight 5 83.68 Quite High
Anxiety Disorder 42 82.92 Quite High
Ganglion Cysts 6 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the synthesis of NPY, ENK and NT is enhanced in TIDA neurons during lactation and that these neuromessengers may be co-released together with DA from the ME to regulate the suckling-induced prolactin secretion at the hypothalamic and/or pituitary levels.
Positive_regulation (enhanced) of Gene_expression (synthesis) of NT in neurons associated with enkephalin
1) Confidence 0.66 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.09 Pain Relevance 0.63
Intracerebral injection of neurotensin into specific brain loci in rats produces hyperalgesia due to the release of cholecystokinin (CCK) in the spinal cord.
Positive_regulation (injection) of Gene_expression (injection) of neurotensin in brain associated with hyperalgesia, cholecystokinin and spinal cord
2) Confidence 0.47 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10202849 Disease Relevance 0.10 Pain Relevance 0.64
Similarly, injection of the CART peptide either into the third, fourth, or the lateral ventricle suppressed food intake [11,12,14,19,20] and stimulated expression of c-Fos in NTS, the parabranchial nucleus, PVN and DMH [21,22].
Positive_regulation (stimulated) of Gene_expression (expression) of NTS in lateral ventricle associated with medulla
3) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.29 Pain Relevance 0.87
An examination of the effects of footshock stress on the content of prepro-NT mRNA in the dopamine cell body groups of the ventral mesencephalon would be of interest in assessing whether stress enhances NT gene expression or alters the characteristics of release of this neuropeptide in the ventral mesencephalon.
Spec (whether) Positive_regulation (enhances) of Gene_expression (expression) of NT in cell body associated with stress, dopamine and neuropeptide
4) Confidence 0.18 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1361117 Disease Relevance 0.52 Pain Relevance 0.58
Haloperidol-induced increase of striatal enkephalin mRNA is totally abolished in NGFI-B KO mice whereas the increase of neurotensin mRNA expression is reduced by 50%.
Positive_regulation (increase) of Gene_expression (expression) of neurotensin mRNA associated with targeted disruption and enkephalin
5) Confidence 0.09 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.47 Pain Relevance 0.55
Bronchopulmonary immune activation following i.t. administration of Mv-NC increased c-Fos expression within the dorsolateral part (SolDL) of the nTS, consistent with anatomical studies in cats in which the dorsolateral part (together with the ventrolateral part) of the nTS at the level of the AP receives the greatest input from afferent vagal fibers arising from the intrathoracic trachea and upper right lobe of the lung (Kalia and Mesulam, 1980), and consistent with our findings that bronchopulmonary, but not s.c. immune activation, increased c-Fos expression in the SolDL.
Positive_regulation (increased) of Gene_expression (expression) of nTS in right lobe
6) Confidence 0.08 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.22 Pain Relevance 0.16
Bronchopulmonary immune activation following i.t. administration of Mv-NC increased c-Fos expression within the dorsolateral part (SolDL) of the nTS, consistent with anatomical studies in cats in which the dorsolateral part (together with the ventrolateral part) of the nTS at the level of the AP receives the greatest input from afferent vagal fibers arising from the intrathoracic trachea and upper right lobe of the lung (Kalia and Mesulam, 1980), and consistent with our findings that bronchopulmonary, but not s.c. immune activation, increased c-Fos expression in the SolDL.
Positive_regulation (increased) of Gene_expression (expression) of nTS in right lobe
7) Confidence 0.08 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.19 Pain Relevance 0.14
Finally, intra-atrial injections of the 5-HT3 receptor agonist PBG, which are thought to selectively activate cardiopulmonary afferent vagal fibers (Coleridge and Coleridge, 1984), increased c-Fos expression in the SolDL and the adjacent gelatinous part of the nTS at the level of the AP, but not other subdivisions of the nTS (see de Vries et al., 2005).
Positive_regulation (increased) of Gene_expression (expression) of nTS associated with porphyria and agonist
8) Confidence 0.08 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.10 Pain Relevance 0.11
Increases in c-Fos expression in the nTS and in DRI serotonergic neurons occurred 12 h following challenge with Mv-NC, consistent with previous studies describing effects of peripheral immune activation on extracellular concentrations of 5-HT in limbic brain regions (including the prefrontal cortex and hippocampus, which are innervated by DRI serotonergic neurons (Azmitia, 1981; Porrino and Goldman-Rakic, 1982)), elevating extracellular concentrations of 5-HT up to 8 h following immune challenge (Dunn, 1992; Lavicky and Dunn, 1995; Linthorst et al., 1996).
Positive_regulation (Increases) of Gene_expression (expression) of nTS in hippocampus associated with hippocampus
9) Confidence 0.08 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.08 Pain Relevance 0.09
The dorsal motor nucleus of the vagus nerve (DMX), lying next to the NTS, has the highest density of MC4R in the brain [90] and may mediate the anorexia due to activation of the NTS POMC neurones by CCK [88].
Positive_regulation (activation) of Gene_expression (neurones) of NTS in vagus nerve associated with medulla, anorexia, cholecystokinin and vagus nerve
10) Confidence 0.07 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.18 Pain Relevance 0.85
Increases in c-Fos expression in the nTS and in DRI serotonergic neurons occurred 12 h following challenge with Mv-NC, consistent with previous studies describing effects of peripheral immune activation on extracellular concentrations of 5-HT in limbic brain regions (including the prefrontal cortex and hippocampus, which are innervated by DRI serotonergic neurons (Azmitia, 1981; Porrino and Goldman-Rakic, 1982)), elevating extracellular concentrations of 5-HT up to 8 h following immune challenge (Dunn, 1992; Lavicky and Dunn, 1995; Linthorst et al., 1996).
Positive_regulation (Increases) of in cortex Gene_expression (expression) of nTS in hippocampus associated with hippocampus
11) Confidence 0.03 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.08 Pain Relevance 0.09

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