INT80500

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.37
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
neuronal 1
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 12 100.00 Very High Very High Very High
cINOD 6 100.00 Very High Very High Very High
Inflammation 5 100.00 Very High Very High Very High
ischemia 57 98.98 Very High Very High Very High
rheumatoid arthritis 1 95.88 Very High Very High Very High
Glutamate 19 85.28 High High
nMDA receptor 33 50.00 Quite Low
COX2 1 25.00 Low Low
Analgesic 1 25.00 Low Low
bDMF 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Cv General 4 Under Development 2 98.98 Very High Very High Very High
Injury 25 98.84 Very High Very High Very High
Thrombosis 1 97.04 Very High Very High Very High
Rheumatoid Arthritis 1 95.88 Very High Very High Very High
Ulcers 1 91.56 High High
Death 9 81.72 Quite High
Cv Unclassified Under Development 17 77.20 Quite High
Hypoxia 55 71.96 Quite High
Peptic Ulcer 3 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, based on vitro and in vivo studies, it appears that during and following cerebral ischemia, it is likely that under depolarizing conditions, NCX1 can contribute to Ca2+ influx and neuronal injury.
Localization (contribute) of NCX1 in neuronal associated with cv general 4 under development, ischemia and injury
1) Confidence 0.61 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.42 Pain Relevance 0.29
NCX-4016, a nitric oxide non-steroidal anti-inflammatory drug (NO-NSAID) which can inhibit cyclooxygenase as well as release nitric oxide, is under development by NicOx as a potential treatment for thrombosis, inflammation and rheumatoid arthritis.
Localization (release) of NCX-4016 associated with inflammation, rheumatoid arthritis, cinod and thrombosis
2) Confidence 0.36 Published 1998 Journal IDrugs Section Abstract Doc Link 18465536 Disease Relevance 0.39 Pain Relevance 0.32
The following primary antibodies were used: rabbit anti-ERK, mouse anti-phospho ERK, mouse anti-Bcl-2, rabbit anti-Bax (Assay Designs, Ann Arbor, MI, USA), mouse anti-SERCA2a, mouse anti-NCX (Affinity Bioreagents, Rockford, IL, USA), and mouse anti-?
Localization (used) of NCX
3) Confidence 0.34 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.18 Pain Relevance 0
We examined the effects of NS-398, the cyclooxygenase (COX)-2 selective inhibitor, and nitric oxide (NO)- releasing aspirin (NCX-4016) on gastric mucosal ulcerogenic and healing responses in experimental animals, in comparison with those of nonselective COX inhibitors such as indomethacin and aspirin.
Localization (releasing) of NCX-4016 associated with aspirin
4) Confidence 0.02 Published 1998 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10069692 Disease Relevance 0.39 Pain Relevance 0.41

General Comments

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