INT80549

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 53
Total Number 54
Disease Relevance 42.76
Pain Relevance 9.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
T cells 9
epithelial cells 5
brain 3
leukocyte 3
polymorphonuclear leukocytes 3
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 67 100.00 Very High Very High Very High
Inflammation 868 99.68 Very High Very High Very High
endometriosis 536 99.60 Very High Very High Very High
Angina 48 99.36 Very High Very High Very High
substance P 60 99.18 Very High Very High Very High
dexamethasone 17 99.12 Very High Very High Very High
rheumatoid arthritis 179 98.92 Very High Very High Very High
psoriasis 519 97.80 Very High Very High Very High
cytokine 386 97.72 Very High Very High Very High
cva 55 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 1222 100.00 Very High Very High Very High
Endometriosis 700 100.00 Very High Very High Very High
Diabetes Mellitus 248 100.00 Very High Very High Very High
Nicotine Addiction 1853 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 209 99.80 Very High Very High Very High
INFLAMMATION 982 99.68 Very High Very High Very High
Atherosclerosis 50 99.68 Very High Very High Very High
Infection 185 99.50 Very High Very High Very High
Cv General 3 Under Development 81 99.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 188 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that smoking may lead to increased monocyte-HUVEC adhesion by influencing an endothelial Mac-1 ligand, with ICAM-1 the prime candidate, or that smoking may induce conformational, or other, alterations to Mac-1, leading to increased affinity for ICAM-1.
ICAM-1 Binding (affinity) of in monocyte associated with nicotine addiction and adhesions
1) Confidence 0.47 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.07 Pain Relevance 0.07
This indicates that smoking may lead to increased monocyte-HUVEC adhesion by influencing an endothelial Mac-1 ligand, with ICAM-1 the prime candidate, or that smoking may induce conformational, or other, alterations to Mac-1, leading to increased affinity for ICAM-1.
ICAM-1 Binding (affinity) of in monocyte associated with nicotine addiction and adhesions
2) Confidence 0.47 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.07 Pain Relevance 0.07
Efalizumab inhibits T-cell activation, cutaneous trafficking, and adhesion to keratinocytes through the blockade of LFA-1/ICAM-1 binding, steps in the immunologic cascade that lead to the formation of the psoriatic plaques (Menter et al 2005).
ICAM-1 Binding (binding) of in plaques associated with psoriasis and adhesions
3) Confidence 0.47 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727906 Disease Relevance 0.73 Pain Relevance 0.07
Our studies indicate that SP-induced cellular Ca+2 signals led to the activation of the NF-kappaB pathway, resulting in nuclear translocation of p65/p50 heterodimers that bind to high-affinity tandem kappaB sites on the VCAM-1 promoter, whereas SP activation induced NF-AT activation and ICAM-1 DNA binding.
ICAM-1 Binding (binding) of associated with substance p
4) Confidence 0.45 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.26 Pain Relevance 0.50
This drug binds to CD11a on T cells blocking the interaction between LFA-1 and intercellular adhesion molecule 1 (ICAM-1), its partner molecule for adhesion.
ICAM-1 Binding (interaction) of in T cells associated with adhesions
5) Confidence 0.40 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721342 Disease Relevance 0.32 Pain Relevance 0.03
Intracellular adhesion molecule-1 (ICAM-1) is a major ligand on the endothelial cells for adherence of the activated polymorphonuclear leukocytes.
ICAM-1 Binding (ligand) of in polymorphonuclear leukocytes associated with adhesions
6) Confidence 0.37 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10073782 Disease Relevance 0.89 Pain Relevance 0.45
Cellular uptake of liposomes targeted to intercellular adhesion molecule-1 (ICAM-1) on bronchial epithelial cells.
ICAM-1 Binding (targeted) of in epithelial cells associated with inflammation and adhesions
7) Confidence 0.37 Published 1999 Journal Biochim. Biophys. Acta Section Title Doc Link 10407086 Disease Relevance 0.20 Pain Relevance 0.19
Cellular uptake of liposomes targeted to intercellular adhesion molecule-1 (ICAM-1) on bronchial epithelial cells.
intercellular adhesion molecule-1 Binding (targeted) of in epithelial cells associated with inflammation and adhesions
8) Confidence 0.37 Published 1999 Journal Biochim. Biophys. Acta Section Title Doc Link 10407086 Disease Relevance 0.20 Pain Relevance 0.19
Regulation of neutrophil migration into inflammatory sites reflects interactions between the IL-8 chemokine and the ICAM-1 adhesion molecule.
ICAM Binding (interactions) of in neutrophil associated with chemokine, inflammation and adhesions
9) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.49 Pain Relevance 0.24
Evidence for alternate splicing resulting in two mRNA species directly encoding either sICAM-1 or membrane-bound ICAM-1 in humans has been presented [183].
ICAM-1 Binding (bound) of
10) Confidence 0.36 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.37 Pain Relevance 0.04
It is also a possibility that the reduced level of ICAM-1 expression in normal gingival tissues could reflect ongoing shedding of membrane-bound ICAM-1.
ICAM-1 Binding (bound) of
11) Confidence 0.36 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.09 Pain Relevance 0.11
It is also a possibility that the reduced level of ICAM-1 expression in normal gingival tissues could reflect ongoing shedding of membrane-bound ICAM-1.
ICAM-1 Binding (bound) of
12) Confidence 0.36 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.09 Pain Relevance 0.11
Evidence for alternate splicing resulting in two mRNA species directly encoding either sICAM-1 or membrane-bound ICAM-1 in humans has been presented [183].
ICAM-1 Binding (bound) of
13) Confidence 0.36 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.37 Pain Relevance 0.04
After exposure to SP, DMEC expressed significant levels of both intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which was accompanied by increased binding to leukocytes expressing the appropriate integrin counter receptors for these CAM.
ICAM-1 Binding (binding) of in leukocytes associated with adhesions and substance p
14) Confidence 0.35 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.52 Pain Relevance 0.61
The LFA-1 integrin binds to the cognate ligand, the intercellular adhesion molecule (ICAM)-1, expressed on the surface of the endothelial and epithelial cells as well as on antigen-presenting cells.
ICAM Binding (binds) of in epithelial cells associated with adhesions
15) Confidence 0.35 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.68 Pain Relevance 0.22
Genotyping of ICAM-1
ICAM Binding (Genotyping) of
16) Confidence 0.34 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2828103 Disease Relevance 0.08 Pain Relevance 0
Haplotype analysis did not reveal any ICAM1 haplotypes associated more strongly with the trait than single alleles.
ICAM1 Binding (associated) of
17) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.65 Pain Relevance 0
Intracellular adhesion molecule-1 (ICAM-1) is a major ligand on the endothelial cells for adherence of the activated polymorphonuclear leukocytes.
adhesion molecule-1 Binding (ligand) of in polymorphonuclear leukocytes associated with adhesions
18) Confidence 0.33 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10073782 Disease Relevance 0.90 Pain Relevance 0.45
After binding to the cell surface, the anti-ICAM-1 immunoliposomes are rapidly internalised by the epithelial cells.
anti-ICAM-1 Binding (binding) of in epithelial cells
19) Confidence 0.33 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.16 Pain Relevance 0.11
A growing number of studies report a significant association between elevated sICAM-1 levels, and the presence of most vascular diseases; the prediction of future adverse events; and poor prognosis [128,131,134,142-149].
sICAM-1 Binding (association) of associated with increased venous pressure under development
20) Confidence 0.32 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.43 Pain Relevance 0.30

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