INT80550

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.80
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
primary sensory neurons 2
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 50 100.00 Very High Very High Very High
Inflammation 74 99.64 Very High Very High Very High
Angina 4 95.44 Very High Very High Very High
dorsal root ganglion 103 94.20 High High
Peripheral nerve injury 17 92.40 High High
antinociception 20 91.60 High High
Spinal cord 49 90.08 High High
Lasting pain 14 89.52 High High
Chronic pancreatitis 1 85.52 High High
substance P 5 66.40 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 13 100.00 Very High Very High Very High
Cancer 7 100.00 Very High Very High Very High
Nervous System Injury 31 99.98 Very High Very High Very High
INFLAMMATION 83 99.64 Very High Very High Very High
Gastrointestinal Neoplasms 2 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 5 99.44 Very High Very High Very High
Nociception 41 97.92 Very High Very High Very High
Myocardial Infarction 7 97.52 Very High Very High Very High
Disease 15 97.32 Very High Very High Very High
Death 5 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since this AMP concentration is below Km, PAP could produce linear increases in adenosine as the extracellular AMP concentration increases.
Positive_regulation (increases) of Gene_expression (produce) of PAP associated with adenocard
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.50 Pain Relevance 0.95
Since this AMP concentration is below Km, PAP could produce linear increases in adenosine as the extracellular AMP concentration increases.
Positive_regulation (increases) of Gene_expression (produce) of PAP associated with adenocard
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.48 Pain Relevance 0.85
These results suggest that the increase of serum PAP levels in patients with gastrointestinal cancers reflects an ectopic expression of PAP in cancer cells and that increased serum levels of PAP in acute pancreatitis are correlated with the disease severity and are prolonged than those of other pancreatic markers.
Positive_regulation (increased) of Gene_expression (expression) of PAP associated with cancer, pancreatitis, gastrointestinal neoplasms and disease
3) Confidence 0.42 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389686 Disease Relevance 1.42 Pain Relevance 0.09
were largely non-overlapping, there was significant overlap between PAP+ axon terminals and PKC?
Positive_regulation (overlap) of Gene_expression (overlap) of PAP
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.05 Pain Relevance 0.14
Moreover, we found that PAP functioned as an ectonucleotidase with relative specificity adenosine 5?
Positive_regulation (ectonucleotidase) of Gene_expression (functioned) of PAP associated with adenocard
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.20 Pain Relevance 0.17
With increasing quartile of D-dimer and PAP levels but not of PAI-1, there was an independent increased risk of myocardial infarction or coronary death, but not of angina.
Neg (not) Positive_regulation (increasing) of Gene_expression (levels) of PAP associated with angina, death and myocardial infarction
6) Confidence 0.08 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10073948 Disease Relevance 1.09 Pain Relevance 0.19
Baseline CIMT levels of ASAP and ENHANCE were ?
Positive_regulation (Baseline) of Gene_expression (levels) of ASAP
7) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.24 Pain Relevance 0
Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons

Pancreatitis-associated protein (PAP)-I and -II, lectin-related secretory proteins, are members of the regenerating gene (Reg) family.

Positive_regulation (induce) of Gene_expression (expression) of PAP in primary sensory neurons associated with nervous system injury, inflammation and pancreatitis
8) Confidence 0.02 Published 2010 Journal Mol Pain Section Title Doc Link PMC2873504 Disease Relevance 1.81 Pain Relevance 0.71

General Comments

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