INT8056

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2006
Negated 13
Speculated 4
Reported most in Abstract
Documents 34
Total Number 38
Disease Relevance 4.71
Pain Relevance 17.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
hippocampus 8
striatum 6
pars nervosa 2
globus pallidus 2
brain 2
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 156 100.00 Very High Very High Very High
substance P 22 100.00 Very High Very High Very High
Glutamate 16 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
Intracerebroventricular 4 100.00 Very High Very High Very High
Antinociceptive 1 99.98 Very High Very High Very High
Kinase C 19 99.76 Very High Very High Very High
dexamethasone 3 99.60 Very High Very High Very High
Catecholamine 8 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asphyxia 5 100.00 Very High Very High Very High
Hypoglycemia 5 100.00 Very High Very High Very High
Sprains And Strains 3 100.00 Very High Very High Very High
Aids-related Complex 2 99.88 Very High Very High Very High
Dystonia 8 99.84 Very High Very High Very High
Convulsion 11 98.16 Very High Very High Very High
Hypertension 2 98.04 Very High Very High Very High
Body Weight 3 98.00 Very High Very High Very High
Shock 5 97.44 Very High Very High Very High
Generalized Anxiety Disorder 4 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of cells with cycloheximide (a protein synthesis inhibitor; 10 microM) did not affect the forskolin- or PMA-induced increase of proENK mRNA.
Neg (not) Regulation (affect) of Positive_regulation (increase) of proENK mRNA
1) Confidence 0.59 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8923515 Disease Relevance 0 Pain Relevance 0.41
Dexamethasone (1 microM) did not affect the forskolin-induced increase of proENK mRNA levels.
Neg (not) Regulation (affect) of Positive_regulation (increase) of proENK mRNA associated with dexamethasone
2) Confidence 0.59 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8923515 Disease Relevance 0 Pain Relevance 0.34
Effects of c-fos antisense oligodeoxynucleotide on 5-HT-induced upregulation of preprodynorphin, preproenkephalin, and glutamic acid decarboxylase mRNA expression in cultured rat spinal dorsal horn neurons.
Regulation (Effects) of Positive_regulation (upregulation) of preproenkephalin in spinal associated with enkephalin and dorsal horn neuron
3) Confidence 0.59 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 12963037 Disease Relevance 0.22 Pain Relevance 0.70
The in vivo short-term effect of melatonin on kainic acid (KA)-induced proenkephalin (proENK) or prodynorphin (proDYN) mRNA, and on AP-1 protein levels in the rat hippocampus, were studied.
Regulation (effect) of Positive_regulation (induced) of proenkephalin in hippocampus associated with hippocampus
4) Confidence 0.58 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.09
However, these increases did not show the potentiative effect on KA-induced increases of proENK and proDYN mRNA level.
Regulation (effect) of Positive_regulation (increases) of proENK
5) Confidence 0.55 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.04
The enhancement in proenkephalin mRNA caused by TPA (10 nmol/l) was not affected by the cyclooxygenase inhibitor indomethacin (5 mumol/l).
Neg (not) Regulation (affected) of Positive_regulation (enhancement) of proenkephalin mRNA
6) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8774948 Disease Relevance 0 Pain Relevance 0.05
The effect of L-arginine (L-ARG), a nitric oxide donor, or Nomega-nitro-L-arginine (L-NAME), a nitric oxide synthase inhibitor, on the regulation of kainic acid (KA)-induced proenkephalin (proENK) and prodynorphin (proDYN) mRNA expressions in rat hippocampus was studied.
Regulation (regulation) of Positive_regulation (induced) of proENK in hippocampus associated with hippocampus
7) Confidence 0.48 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
Kainic acid alters the metabolism of Met5-enkephalin and the level of dynorphin A in the rat hippocampus.
Regulation (alters) of Positive_regulation (metabolism) of Met5-enkephalin in hippocampus associated with dynorphin, hippocampus and enkephalin
8) Confidence 0.45 Published 1986 Journal J. Neurosci. Section Title Doc Link 2876067 Disease Relevance 0.09 Pain Relevance 0.64
It has also been demonstrated that chronic treatment of rats with the dopamine receptor blocker, haloperidol, results in an increase in the levels of enkephalin peptides and proenkephalin mRNA in this brain region.
Regulation (results) of Positive_regulation (increase) of proenkephalin mRNA in brain associated with dopamine receptor and enkephalin
9) Confidence 0.45 Published 1987 Journal Brain Res. Section Abstract Doc Link 3580841 Disease Relevance 0 Pain Relevance 0.47
Boroleucine prolonged the leucine enkephalin degradation half-life 1.6-1.9-fold in each medium at 0.1 microM concentrations, 1/1000th the concentration of leucine enkephalin.
Regulation (prolonged) of Positive_regulation (concentration) of enkephalin associated with enkephalin
10) Confidence 0.45 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 2143133 Disease Relevance 0 Pain Relevance 0.70
We investigated the molecular mechanisms responsible for the preproenkephalin A mRNA increase following catecholamine depletion by reserpine using quantitative in situ hybridization at the cellular level.
Spec (investigated) Regulation (responsible) of Spec (investigated) Positive_regulation (increase) of enkephalin associated with catecholamine
11) Confidence 0.44 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7494455 Disease Relevance 0 Pain Relevance 0.12
[Combined effect of intracerebroventricular injections of angiotensin II, met-enkephalin and acetylcholine on mean arterial pressure in albino rats].
Regulation (effect) of Positive_regulation (injections) of enkephalin associated with enkephalin and intracerebroventricular
12) Confidence 0.44 Published 1988 Journal Acta Physiol Pharmacol Latinoam Section Title Doc Link 3201998 Disease Relevance 0.06 Pain Relevance 0.57
On the other hand, the antinociceptive response to intracerebroventricular (i.c.v.) injection of SP or of the synthetic enkephalin analog D-Ala2,D-Leu5-enkephalin, as well as the hypertensive response to i.c.v.
Regulation (response) of Positive_regulation (injection) of enkephalin associated with hypertension, enkephalin, intracerebroventricular, antinociceptive and substance p
13) Confidence 0.44 Published 1989 Journal Brain Res. Section Abstract Doc Link 2470472 Disease Relevance 0.18 Pain Relevance 1.07
The chronic L-DOPA treatment in 6-hydroxydopamine-lesioned rats was found to partially reverse the lesion-induced down-regulation of substance P mRNA expression, without significantly affect the up-regulation of enkephalin when considering the neostriatum as a whole.
Neg (without) Regulation (affect) of Positive_regulation (up-regulation) of enkephalin associated with enkephalin and substance p
14) Confidence 0.43 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221930 Disease Relevance 0 Pain Relevance 0.51
It was suggested that an enkephalin innervation of the pars nervosa originating from the magnocellular hypothalamic nuclei might regulate the secretion of neurohypophyseal hormones.
Spec (might) Regulation (regulate) of Positive_regulation (innervation) of enkephalin in pars nervosa associated with enkephalin
15) Confidence 0.42 Published 1980 Journal Nature Section Abstract Doc Link 6244503 Disease Relevance 0 Pain Relevance 0.76
It appears that ARC mRNA levels of proDyn, proEnk, and POMC are directly related to the amount of food consumed and/or changes in body weight in food-restricted and food-deprived rats.
Regulation (related) of Spec (appears) Positive_regulation (levels) of proEnk in ARC associated with body weight and aids-related complex
16) Confidence 0.42 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8928900 Disease Relevance 0.66 Pain Relevance 0.24
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Neg (not) Regulation (affected) of Positive_regulation (elevations) of proENK
17) Confidence 0.41 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
Thus, the birth-related increases in TH, DBH, NPY, and ENK mRNA levels in the rat adrenal medulla are dependent on postnatal oxygenation.
Regulation (dependent) of Positive_regulation (increases) of ENK mRNA in adrenal medulla associated with medulla
18) Confidence 0.39 Published 1995 Journal Pediatr. Res. Section Abstract Doc Link 7651752 Disease Relevance 0.08 Pain Relevance 0.40
The effect of L-arginine (L-ARG), a nitric oxide donor, or Nomega-nitro-L-arginine (L-NAME), a nitric oxide synthase inhibitor, on the regulation of kainic acid (KA)-induced proenkephalin (proENK) and prodynorphin (proDYN) mRNA expressions in rat hippocampus was studied.
Regulation (regulation) of Positive_regulation (induced) of proenkephalin in hippocampus associated with hippocampus
19) Confidence 0.35 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
Running had no effect on dynorphin and enkephalin mRNAs in the FSL strain but it decreased dynorphin mRNA, and there was a trend to increased enkephalin mRNA in the FRL rats.
Neg (no) Regulation (effect) of Positive_regulation (increased) of enkephalin associated with dynorphin, enkephalin and sprains and strains
20) Confidence 0.35 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16034445 Disease Relevance 0.73 Pain Relevance 1.13

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