INT80599

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Context Info
Confidence 0.28
First Reported 1999
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.46
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
striatum 4
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 6 99.74 Very High Very High Very High
Dopamine 18 99.68 Very High Very High Very High
agonist 8 98.20 Very High Very High Very High
antagonist 8 89.84 High High
cINOD 2 83.60 Quite High
Glutamate receptor 4 77.92 Quite High
dopamine receptor 6 75.00 Quite High
cytokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 2 85.16 High High
INFLAMMATION 2 83.40 Quite High
Colon Cancer 3 75.00 Quite High
Cancer 1 74.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, 6-cyano-7-nitroquinoxaline-2,3-dione (1 microM-1 mM) did not significantly affect induction of c-fos and zif268 by D1 receptor stimulation (SKF 38393, 2 mg/kg, i.p.) in the dopamine-depleted striatum.
Neg (not) Regulation (affect) of Positive_regulation (induction) of zif268 in striatum associated with dopamine
1) Confidence 0.28 Published 1999 Journal Neuroscience Section Abstract Doc Link 10077330 Disease Relevance 0 Pain Relevance 0.94
Local infusion of tetrodotoxin had minimal effect on induction of c-fos and zif268 in the dopamine-depleted striatum.
Regulation (effect) of Positive_regulation (induction) of zif268 in striatum associated with tetrodotoxin and dopamine
2) Confidence 0.17 Published 1999 Journal Neuroscience Section Abstract Doc Link 10077330 Disease Relevance 0 Pain Relevance 0.90
These data, coupled with deletion and mutation analysis of both the Egr-1 and NAG-1 gene promoters, indicate that activation of NAG-1 by these compounds was dependent on prior induction of Egr-1, and induction of these responses was PPARgamma-independent.
Regulation (dependent) of Positive_regulation (induction) of Egr-1
3) Confidence 0.11 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16155208 Disease Relevance 0.46 Pain Relevance 0.24

General Comments

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