INT80626

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 46
Total Number 47
Disease Relevance 9.84
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
Anatomy Link Frequency
HeLa 1
band 1
thyroid gland 1
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 90 100.00 Very High Very High Very High
potassium channel 4 99.76 Very High Very High Very High
Pain 139 98.72 Very High Very High Very High
Dynorphin 41 96.84 Very High Very High Very High
Spinal cord 16 96.32 Very High Very High Very High
imagery 19 92.76 High High
Neuropathic pain 4 91.76 High High
Kappa opioid receptor 32 84.72 Quite High
Lasting pain 48 79.60 Quite High
Osteoarthritis 112 58.96 Quite High
Disease Link Frequency Relevance Heat
Repression 164 99.58 Very High Very High Very High
Rheumatoid Arthritis 720 99.22 Very High Very High Very High
Pain 198 98.72 Very High Very High Very High
Alzheimer's Dementia 4 96.48 Very High Very High Very High
Nociception 13 94.72 High High
Neuropathic Pain 4 91.76 High High
Neuroblastoma 217 90.92 High High
Hallucination 50 83.76 Quite High
Disease 4 81.60 Quite High
Arthritis 20 81.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, ‘in vivo’ binding of DREAM to the fragment encompassing the RARE of the RAR?
DREAM Binding (binding) of
1) Confidence 0.43 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.41 Pain Relevance 0
A prevalence of protein–protein interactions over binding of DREAM to DNA has been previously reported in the de-repression of DRE sites following cAMP stimulation, which depends on the interaction of DREAM with ?
DREAM Binding (interaction) of associated with repression
2) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.20 Pain Relevance 0
To analyze binding of DREAM to these sites ‘in vivo’, we carried out ChIP assays with primers amplifying the p21Cip1 promoter fragments that include the VDRE or the RARE motifs.
DREAM Spec (analyze) Binding (binding) of
3) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.31 Pain Relevance 0
Furthermore, association of DREAM with the VDRE was sensitive to Ca2+, decreasing when CaCl2 was present in the binding buffer (Figure 1D).
DREAM Binding (association) of
4) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0
A prevalence of protein–protein interactions over binding of DREAM to DNA has been previously reported in the de-repression of DRE sites following cAMP stimulation, which depends on the interaction of DREAM with ?
DREAM Binding (binding) of associated with repression
5) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.18 Pain Relevance 0
The finding that mutation of either LCD in DREAM abolishes stimulation mediated by the HREs indicates that the interaction of DREAM with the transcriptional complex formed on the HRE site could be crucial for the transactivating effect of this factor.
DREAM Binding (interaction) of
6) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.15 Pain Relevance 0
Moreover, our results indicate that the DRE motif can also function in a DR arrangement and show the flexibility of DREAM binding to DNA, since this factor can recognize sequences with different spacing between the binding motifs.
DREAM Binding (binding) of
7) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Whereas Ca2+ modifies DREAM conformation by binding to the EF-hand motifs, leading to release of DREAM from the DRE (1,5), cAMP-dependent derepression involves a direct protein–protein interaction of DREAM with ?
DREAM Binding (interaction) of
8) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.16 Pain Relevance 0.11
Carrion and colleagues [8,9] showed the binding of DREAM to DNA, which implied a role in the hierarchical machinery regulating the rat dynorphin-encoding prodynorphin (pdyn) gene in a Ca2+-dependent manner.
DREAM Binding (binding) of associated with dynorphin
9) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.40 Pain Relevance 1.31
Since the LCDs in DREAM are similar to those present in several nuclear receptor coactivators, we tested the possibility that DREAM could form a complex with the receptor heterodimers when bound to DNA.
DREAM Binding (bound) of
10) Confidence 0.33 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Future studies will determine whether the association of DREAM with coactivators through the LCDs could mediate the recruitment of DREAM to the mediator complex that results in the potentiation of HRE transcription by DREAM.
DREAM Binding (recruitment) of
11) Confidence 0.33 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.
DREAM Binding (heterodimer) of associated with rheumatoid arthritis
12) Confidence 0.33 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0
This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.
DREAM Binding (binding) of associated with rheumatoid arthritis
13) Confidence 0.33 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0
Although DREAM binds in vitro to the HREs independently of the presence of the occupied receptors, ChIP assays demonstrated that in vivo binding could only be detected upon incubation of cells with the appropriate ligand.
DREAM Binding (binds) of
14) Confidence 0.33 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.18 Pain Relevance 0
HREs are composed of two copies of a hexameric motif rather similar to the DRE, and the presence of two motifs probably contributes to the stabilization of DREAM binding to these sequences.
DREAM Binding (binding) of
15) Confidence 0.32 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
The fact that DREAM binds to DREs as a tetramer may contribute to this flexibility.
DREAM Binding (binds) of
16) Confidence 0.32 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
Thus, DREAM represents the first known Ca2+-binding protein to function as a DNA-binding transcriptional regulator.
DREAM Binding (binding) of
17) Confidence 0.30 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.08 Pain Relevance 0.12
Thus, DREAM represents the first known Ca2+-binding protein to function as a DNA-binding transcriptional regulator.
DREAM Binding (binding) of
18) Confidence 0.30 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.08 Pain Relevance 0.12
Here we isolate a new transcriptional repressor, DRE-antagonist modulator (DREAM), which specifically binds to the DRE.
DREAM Binding (binds) of associated with antagonist
19) Confidence 0.30 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.09 Pain Relevance 0.14
Here we isolate a new transcriptional repressor, DRE-antagonist modulator (DREAM), which specifically binds to the DRE.
DRE-antagonist Binding (binds) of associated with antagonist
20) Confidence 0.30 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.09 Pain Relevance 0.14

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