INT80627

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Context Info
Confidence 0.03
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 0.72
Pain Relevance 0.49

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cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
KCNIP3 (Homo sapiens)
Dre (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 100.00 Very High Very High Very High
Pain 9 93.12 High High
Enkephalin 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 9 93.12 High High
Rheumatoid Arthritis 120 88.24 High High
Repression 24 83.60 Quite High
Neuroblastoma 36 64.80 Quite High
Apoptosis 6 60.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we isolate a new transcriptional repressor, DRE-antagonist modulator (DREAM), which specifically binds to the DRE.
DREAM Binding (binds) of DRE associated with antagonist
1) Confidence 0.03 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.09 Pain Relevance 0.14
Here we isolate a new transcriptional repressor, DRE-antagonist modulator (DREAM), which specifically binds to the DRE.
DRE-antagonist Binding (binds) of DRE associated with antagonist
2) Confidence 0.03 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.09 Pain Relevance 0.14
Upon stimulation by Ca2+, DREAM's ability to bind to the DRE and its repressor function are prevented.
DREAM Binding (bind) of DRE
3) Confidence 0.03 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.09 Pain Relevance 0.13
DREAM appears to bind the DRE as a tetramer, and most likely, the DBD is composed upon oligomerization.
DREAM Binding (bind) of DRE
4) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.14 Pain Relevance 0
-CREM participate in a two-site interaction that results in the loss of DREAM binding to the DRE and transcriptional derepression (6).
DREAM Binding (binding) of DRE
5) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.13 Pain Relevance 0.07
As shown in Figure 1A, recombinant DREAM bound to the DR3 with a stronger affinity than to the consensus DRE of the prodynorphin gene (compare lanes 3 and 6).
DREAM Binding (bound) of DRE
6) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.09 Pain Relevance 0
Analysis of these tandem DRE sequences also showed a greater affinity for DREAM than the prodynorphin DRE (3).
DREAM Binding (affinity) of DRE
7) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Association of DREAM to both the DRE and the DR3 was competed with an excess of either unlabeled oligonucleotide, whereas a non-related competitor did not affect retardation (Figure 1B).
DREAM Binding (Association) of DRE
8) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
Our results show that DREAM can bind to HREs in vitro even more efficiently than to the original DRE from the prodynorphin gene (1).
DREAM Binding (bind) of DRE
9) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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