INT8063

Context Info Confidence 0.36 First Reported 1992 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 15 Total Number 15 Disease Relevance 9.15 Pain Relevance 1.30

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

Anatomy Link Frequency colon 1 brain 1 T29H 1 body 1 RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Neurotransmitter 2 100.00 corticosteroid 1 99.78 cINOD 17 98.76 Pain 4 94.52 Migraine 34 91.12 aspirin 1 84.24 Inflammation 4 76.44 Chronic pancreatitis 5 73.84 Central nervous system 1 66.68 Opioid 1 55.04

Disease Link Frequency Relevance Heat Hyperplasia 3 99.80 Cancer 339 98.44 Colon Cancer 34 98.26 Disease 45 97.28 Epstein-barr Virus 21 96.32 Infection 11 96.16 INFLAMMATION 7 95.88 Hypoxia 2 94.92 Pancreatic Cancer 16 94.52 Pain 4 94.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A potential major drawback, comparing RAS to CES, is the absence of haptic feedback in RAS.

Regulation (absence) of RAS

1) Confidence 0.36 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0.19 Pain Relevance 0.09

In this way the brain RAS interacts with other neurotransmitter and neuromodulator systems and contributes to the regulation of blood pressure, body fluid homeostasis, cyclicity of reproductive hormones and sexual behavior, and perhaps plays a role in other functions such as memory acquisition and recall, sensory acuity including pain perception and exploratory behavior.

Regulation (regulation) of RAS in body associated with pain and neurotransmitter

2) Confidence 0.34 Published 1992 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 1361394 Disease Relevance 0.35 Pain Relevance 0.14

Furthermore, suppression of oncogenic RAS activity by stable siRNA specific for HRAS(V12) led to the demethylation and re-expression of OPCML in T29H cells, demonstrating that oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML.

Regulation (responsible) of oncogenic RAS in T29H

3) Confidence 0.26 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.32 Pain Relevance 0.06

Topical corticosteroids can often control RAS.

Regulation (control) of RAS associated with corticosteroid

4) Confidence 0.23 Published 2006 Journal Oral Dis Section Abstract Doc Link 16390463 Disease Relevance 0.92 Pain Relevance 0.15

However, serum ACE levels may not reflect the actual RAS activity because non-ACE pathways affecting RAS activity have been described.

Regulation (affecting) of RAS

5) Confidence 0.20 Published 2008 Journal Hepatogastroenterology Section Body Doc Link 19102399 Disease Relevance 0.06 Pain Relevance 0

Although this brain RAS appears to be regulated independently from the peripheral RAS, circulating angiotensins do exert a portion of their actions via stimulation of brain angiotensin receptors located in circumventricular organs.

Neg (independently) Regulation (regulated) of RAS in brain

6) Confidence 0.18 Published 1992 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 1361394 Disease Relevance 0 Pain Relevance 0.03

Some of these miRNAs mediate key mRNA targets such as Ras, E2F5, c-myc, eIF5A, and PP2B.

Regulation (targets) of Ras

7) Confidence 0.12 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.73 Pain Relevance 0

The Kirsten ras ( K-ras ) oncogene regulates the expression of several genes, including suppressing the expression of peroxisomal proliferator-activated receptor gamma (PPARgamma).

Regulation (regulates) of ras

8) Confidence 0.06 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.73 Pain Relevance 0.11

Johnson et al. showed that the let-7 miRNA family negatively regulated let-60/Ras.

Regulation (regulated) of Ras

9) Confidence 0.06 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.53 Pain Relevance 0

Additionally, the influence of K-ras on DOC-2 transcription was investigated.

Regulation (influence) of ras

10) Confidence 0.05 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11406647 Disease Relevance 1.47 Pain Relevance 0.07

Johnson et al. identified the regulation of let-60, the ortholog of the human RAS oncogene, by let-7 in C. elegans [66].

Regulation (regulation) of RAS

11) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.53 Pain Relevance 0

involved in regulations of Ras activity, cell cycle, and WNT pathway) [131, 132], investigate the disease etiology (e.g., EBV infection, host responses, and hypoxia) [133–135], and evaluate the therapeutic

Regulation (regulations) of Ras associated with hypoxia, epstein-barr virus, disease and infection

12) Confidence 0.01 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.51 Pain Relevance 0

For example, in colon carcinoma the regulation by NSAIDs of the molecular pathways of cellular proliferation includes modulation of Ras and MAP Kinase signal transduction pathways, nuclear factor kB protein activation and cyclin expression [37-40].

Regulation (modulation) of Ras in colon associated with colon cancer, cinod and hyperplasia

13) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2412853 Disease Relevance 0.47 Pain Relevance 0.23

Our study also did not find a relationship between ACE genotype and response to prophylactic drugs influencing the RAS.

Regulation (influencing) of RAS

14) Confidence 0.01 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2311324 Disease Relevance 0.69 Pain Relevance 0.34

Because the gene is mutated in 30%, the regulation of Ras appears to be a further rational anti-tumour strategy.

Regulation (regulation) of Ras associated with cancer

15) Confidence 0.01 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.67 Pain Relevance 0.07

General Comments

This test has worked.