INT80630

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Context Info
Confidence 0.19
First Reported 1999
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A) signal transduction (PDE2A) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) plasma membrane (PDE2A) nucleus (PDE2A)
Anatomy Link Frequency
penis 1
PDE2A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 75.32 Quite High
headache 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 2 98.24 Very High Very High Very High
Apoptosis 5 95.80 Very High Very High Very High
Cancer 6 82.04 Quite High
Colon Cancer 1 78.64 Quite High
INFLAMMATION 1 75.08 Quite High
Pancreatic Cancer 1 50.64 Quite High
Coronary Artery Disease 3 48.48 Quite Low
Increased Venous Pressure Under Development 2 25.00 Low Low
Headache 1 25.00 Low Low
Suicidal Behaviour 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sildenafil, which selectively inhibits phosphodiesterase type 5 (PDE5) found predominantly in the corpora cavernosa of the penis, effectively blocks the degradation of cGMP and enhances erectile function in men with erectile dysfunction.
Protein_catabolism (degradation) of cGMP in penis associated with reprotox - general 2
1) Confidence 0.19 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10078538 Disease Relevance 0.18 Pain Relevance 0
Each family of PDEs is characterized by their ability to bind and degrade cAMP and cGMP but differs in physical and kinetic properties.
Protein_catabolism (degrade) of cGMP
2) Confidence 0.07 Published 2001 Journal Curr Opin Investig Drugs Section Abstract Doc Link 11569947 Disease Relevance 0.73 Pain Relevance 0.08

General Comments

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